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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascimento nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitoria marra da motta Vilalva mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of mL/min/1.73 m2).The RE+BFR session consisted of 50% arterial occlusion pressure during 50 min sessions of HD(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning ***:Several variables were associated with elevated levels of D-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

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The formation of massif anorthosite:Petrology in reverse

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Geoscience Frontiers 2013年第2期4卷 195-198页

作者： nicholas Arndt ISTerre Universite Joseph Fourier:UMR5275CNRS1381 rue de la Piscine38400 St Martin d'HeresFrance

massif anorthosites form when basaltic magma differentiates in crustal magma chambers to form lowdensity plagioclase and a residual liquid whose density was greater than that of enclosing crustal rocks. The plagioclase and minor pyroxene crystallized in-situ on the floor of the magma chamber to produce the anorthosite complex,and the residual liquid migrated downwards,eventually to solidify as dense Fe-rich cumulates some of which were removed to the *** movements were facilitated by high temperatures in Proterozoic continental crust,thus explaining the restriction of large anorthosite massifs to this period in Earth history.

关键词： Anorthosite Petrology Proterozoic

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Neuroprotective properties of dietary saffron：more than just a chemical scavenger？

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Neural Regeneration Research 2017年第2期12卷 210-211页

作者： nicholas V.Skladnev Daniel m.Johnstone Bosch Institute University of SydneyNSWAustralia Discipline of Physiology University of SydneyNSWAustralia

There is increasing evidence that consumption of saffron,a spice derived from the flower of the Crocus savitus plant,has various therapeutic effects,including protection of the central nervous system.

关键词： more Neuroprotective properties of dietary saffron than

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Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery

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Acta Pharmaceutica Sinica B 2018年第2期8卷 147-164页

作者： Angela m.Wagner margaret P.Gran nicholas A.Peppas mcKetta Department of Chemical Engineering The University of Texas at Austin Institute for Biomaterials Drug Delivery and Regenerative Medicine The University of Texas at Austin Department of Biomedical Engineering The University of Texas at Austin Department of Pediatrics Dell Medical School The University of Texas at Austin Department of Surgery and Perioperative Care Dell Medical School The University of Texas at Austin Division of Pharmaceutics College of Pharmacy The University of Texas at Austin

Therapeutic proteins and peptides have revolutionized treatment for a number of diseases, and the expected increase in macromolecule-based therapies brings a new set of challenges for the pharmaceutics field. Due to their poor stability, large molecular weight, and poor transport properties,therapeutic proteins and peptides are predominantly limited to parenteral administration. The short serum half-lives typically require frequent injections to maintain an effective dose, and patient compliance is a growing issue as therapeutic protein treatments become more widely available. A number of studies have underscored the relationship of subcutaneous injections with patient non-adherence, estimating that over half of insulin-dependent adults intentionally skip injections. The development of oral formulations has the potential to address some issues associated with non-adherence including the interference with daily activities, embarrassment, and injection pain. Oral delivery can also help to eliminate the adverse effects and scar tissue buildup associated with repeated injections. However, there are several major challenges associated with oral delivery of proteins and peptides, such as the instability in the gastrointestinal(GI)tract, low permeability, and a narrow absorption window in the intestine. This review provides a detailed overview of the oral delivery route and associated challenges. Recent advances in formulation and drugdelivery technologies to enhance bioavailability are discussed, including the co-administration of compounds to alter conditions in the GI tract, the modification of the macromolecule physicochemical properties, and the use of improved targeted and controlled release carriers.

关键词： Oral delivery Hydrogels Protein delivery Peptide delivery Carbohydrates mucoadhesion

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Size,efficiency,market power,and economies of scale in the African banking sector

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Financial Innovation 2019年第1期5卷 54-75页

作者： Simplice A.Asongu nicholas m.Odhiambo Department of Economics University of South AfricaP.O.Box 392Pretoria 0003South Africa Department of Economics&Development Studies Covenant UniversityOtaNigeria

There is a growing body of evidence that interest rate spreads in Africa are higher for big banks compared to small *** concern is that big banks might be using their market power to charge higher lending rates as they become larger,more efficient,and *** contrast,several studies found that when bank size increases beyond certain thresholds,diseconomies of scale are introduced that lead to *** that case,we also would expect to see widened interest *** study examines the connection between bank size and efficiency to understand whether that relationship is influenced by exploitation of market power or economies of *** a panel of 162 African banks for 2001–2011,we analyzed the empirical data using instrumental variables and fixed effects regressions,with overlapping and non-overlapping thresholds for bank *** found two key ***,bank size increases bank interest rate margins with an inverted U-shaped ***,market power and economies of scale do not increase or decrease the interest rate margins *** main policy implication is that interest rate margins cannot be elucidated by either market power or economies of *** implications are discussed.

关键词： Sub-Saharan Africa Banks Lending rates Efficiency Quiet life hypothesis Competition

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New guidance for using t-SNE:Alternative defaults,hyperparameter selection automation,and comparative evaluation

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Visual Informatics 2022年第2期6卷 87-97页

作者： Robert Gove Lucas Cadalzo nicholas Leiby Jedediah m.Singer Alexander Zaitzeff Two Six Technologies USA

We present new guidelines for choosing hyperparameters for t-SNE and an evaluation comparing these guidelines to current *** guidelines include a proposed empirically optimum guideline derived from a t-SNE hyperparameter grid search over a large collection of data *** also introduce a new method to featurize data sets using graph-based metrics called scagnostics;we use these features to train a neural network that predicts optimal t-SNE hyperparameters for the respective data *** neural network has the potential to simplify the use of t-SNE by removing guesswork about which hyperparameters will produce the best *** evaluate and compare our neural network-derived and empirically optimum hyperparameters to several other t-SNE hyperparameter guidelines from the literature on 68 data *** hyperparameters predicted by our neural network yield embeddings with similar accuracy as the best current t-SNE *** our empirically optimum hyperparameters is simpler than following previously published guidelines but yields more accurate embeddings,in some cases by a statistically significant *** find that the useful ranges for t-SNE hyperparameters are narrower and include smaller values than previously reported in the ***,we also quantify the potential for future improvements in this area:using data from a grid search of t-SNE hyperparameters we find that an optimal selection method could improve embedding accuracy by up to two percentage points over the methods examined in this paper.

关键词： Dimensionality reduction machine learning t-SNE

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Fundamentals of operations management / mark m. Davis, nicholas J. Aquilano, Richard B. Chase. 4th ed.

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丛书名： mcGraw-Hill/Irwin series operations and decision sciences

2003年

作者： mark m. Davis nicholas J. Aquilano Richard B. Chase.

First ed. published under: Aquilano, nicholas J.

ISBN: (数字)0072402857

ISBN: (纸本)007119469X

First ed. published under: Aquilano, nicholas J.

关键词： Production management.

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Endocannabinoids are potential inhibitors of glioblastoma multiforme proliferation

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Journal of Integrative medicine 2023年第2期21卷 120-129页

作者： Ashraf Duzan Desiree Reinken Timothy L.mcGomery nicholas m.Ferencz Jacob m.Plummer mufeed m.Basti School of Pharmacy Wingate UniversityWingateNC 28174USA Applied Science and Technology Department North Carolina State University of Agriculture and TechnologyGreensboroNC 27411USA College of Nursing University of Colorado Anschutz Medical CampusAuroraCO 80045USA Collage of Arts and Science Department of Chemistry and PhysicsWingate UniversityWingateNC 28174USA

Globally,it is evident that glioblastoma multiforme(GBm)is an aggressive malignant cancer with a high mortality rate and no effective treatment *** is classified as the stage-four progression of a glioma tumor,and its diagnosis results in a shortened life *** options for GBm include chemotherapy,immunotherapy,surgical intervention,and conventional pharmacotherapy;however,at best,they extend the patient’s life by a maximum of 5 *** are considered incurable due to their high recurrence rate,despite various aggressive therapeutic approaches which can have many serious adverse ***,classified as endocannabinoids,offer a promising novel therapeutic approach for *** may enhance the apoptosis of GBm cells but have no effect on normal healthy neural *** promote atypical protein kinase C,deactivate fatty acid amide hydrolase enzymes,and activate transient receptor potential vanilloid 1(TRPV1)and TRPV2 to induce pro-apoptotic signaling pathways without increasing endogenous *** previous in vivo studies,endocannabinoids,chemically classified as amide formations of oleic and palmitic acids,have been shown to increase the pro-apoptotic activity of human cancer cells and inhibit cell migration and *** review focuses on the biological synthesis and pharmacology of endogenous cannabinoids for the enhancement of cancer cell apoptosis,which have potential as a novel therapy for GBm.

关键词： Glioblastoma Endocannabinoids Ceramide Apoptosis Chemotherapy Cancer

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Heart healthy equals prostate healthy and statins, aspirin, and/or metformin （S.A.m.） are the ideal recommendations for prostate cancer prevention

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Asian Journal of Andrology 2015年第5期17卷 783-791,I0008页

作者： mark A moyad nicholas J Vogelzang Department of Urology University of Michigan Medical Center Ann Arbor Michigan USA Developmental Therapeutics Committee and Genitourinary Committee for US Oncology Research Comprehensive Cancer Centers of Nevada Las Vegas Nevada USA

Cardiovascular disease （CVD） has been the number one cause of death in the U.S. for 114 of the last 115 years. Lifestyle factors that promote CVD also appear to increase prostate cancer risk and those that reduce CVD risk also appear to reduce the risk of prostate cancer. The largest randomized trials utilizing dietary supplements or pharmacologic agents for prostate cancer prevention （Selenium and Vitamin E Cancer Prevention Trial [SELECT]） have also shed light on the problems and future solutions in this area. Dietary supplements that have not been found to be CVD protective, such as selenium and Vitamin E have not been found to be prostate protective. In addition, over exposure to specific anti-oxidants in nutritionally replete populations may be encouraging cancer growth. Futuretrials of dietary supplements to prevent prostate cancer could be problematic because by the time a definitive trial is initiated the participants will no longer be ＂deficient＂ in the nutrient being tested, which arguably occurred in the SELECT trial. It is also interesting that statins, aspirin, and/or metformin （S.A.m.） are 3 generic, low-cost, heart healthy agents derived from natural sources with separate mechanism of actions, which all appear to have the best benefit to risk ratio compared to any other agent available for prostate cancer prevention, especially aggressive disease, or as an ancillary agent （s） to conventional cancer treatment. It is time to focus on the forest over the trees and recommend proven CVD protective measures for men concerned about their risk of prostate cancer.

关键词： aspirin diet lifestyle metformin prostate cancer statins

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6-weekly bevacizumab versus 4-weekly ranibizumab for neovascular age-related macular degeneration:a 2-year outcome

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 551-555页

作者： Patrick J Chiam Vivian W Ho nicholas m Hickley Venkat Kotamarthi St.Paurs Eye Unit Royal Liverpool University HospitalLiverpool L7 8XPUK Eye Care Centre Leighton HospitalCrewe CW1 4Q JUK Eye Department Leicester Royal InfirmaryLeicester LE15WWUK

AIm： To compare visual acuity and central macular thickness（CmT） changes in neovascular age-related macular degeneration patients treated with either 6weekly bevacizumab regimen or 4 weekly ranibizumab on an as required basis.·mETHODS： Patients made an informed choice between bevacizumab 1.25 mg or ranibizumab 0.5 mg. The selected treatment was administered in the first 3 *** patients were followed-up 6 weekly and ranibizumab 4 weekly. Retreatment criteria was based on the reduction of 〉5 letters in the best-corrected visual acuity（BCVA）, the presence of retinal fluid on optical coherence tomography（OCT） or new retinal haemorrhage.·RESULTS： Visual acuity at 2y bevacizumab patients gained 7. 0 letters and ranibizumab 9. 2（ P = 0. 31, 95 %CI-6.4 to 2.0）. At 2y 86% of bevacizumab and 94%ranibizumab patients had not lost 15 letters or more（P =0.13）. mean CmT decreased at 2y bevacizumab by 146 μm,ranibizumab 160 μm（P =0.72）. mean number of injections was at 2y bevacizumzb 11.9, ranibizumab 10.3（P =0.023）.· CONCLUSION： Bevacizumab 6 weekly on an as required basis was not demonstrably non-inferior to ranibizumab 4 weekly pro re nata（prn） in terms of BCVA and change in CmT. In the bevacizumab group, one more injection was required in the second year compared to the ranibizumab group.

关键词： bevacizumab ranibizumab neovascular age-related macular degeneration treatment on as required basis

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