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Business Model Innovation of Small and Medium-sized Enterprises on the Basis of Value Creation Logic of Balanced Score Card

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学术界 2015年第11期 313-317页

Small and medium-sized enterprises have developed rapidly under the guidance and support of the national industrial policy.Because of the influence of the post financial crisis,the rate of the global economy development decreased and the market competition increased,the profit of small and medium-sized enterprises is on the decline or even in a loss.The paper,based on the value creation logic of Balanced Score Card,put forward that we should,with the Differentiation Strategy as the basis,using Strategy Map and Cascade Strategy,integrate the key internal procedures to increase the strategic preparation of intangible assets to guide the business model innovation of small and medium-sized enterprises and promote the rapid development of small and medium-sized enterprises.

关键词：中小企业平衡计分卡商业模式逻辑价值创新差异化战略产业政策

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涉毒犯罪人员冲动性特征及对再犯的预测作用

中国药物依赖性杂志 2024年第2期33卷 142-147页

作者：楼新娟倪宁李勇辉中国科学院心理研究所中国科学院心理健康重点实验室北京100101 中国科学院大学心理系北京100049 浙江省金华监狱浙江金华321071

目的探讨涉毒犯罪人员的冲动性特点、变化特征,以及冲动性对再犯的预测作用。方法采用横向和纵向研究设计,问卷与行为任务相结合的研究方法,使用UPPS-P、BIS-11量表测量犯罪人员的特质冲动,使用Go/No-Go、信息取样任务测量犯罪人员的状... 详细信息

目的探讨涉毒犯罪人员的冲动性特点、变化特征,以及冲动性对再犯的预测作用。方法采用横向和纵向研究设计,问卷与行为任务相结合的研究方法,使用UPPS-P、BIS-11量表测量犯罪人员的特质冲动,使用Go/No-Go、信息取样任务测量犯罪人员的状态冲动。施测人员共798名。结果(1)对吸毒史、贩毒无吸毒史、诈骗无吸毒史犯罪人员进行比较发现,三组的特质冲动和状态冲动多数维度存在显著性差异(P0.05);(4)积极紧迫性对再犯预测有显著作用(P<0.05)。结论涉毒犯罪人员的冲动性显著高于非涉毒犯罪人员,文化程度越高,冲动性越低。犯罪人员的特质冲动和状态冲动基本保持稳定。积极紧迫性对再犯具有显著的预测作用。

关键词：涉毒犯罪人员冲动特征再犯预测

5-氨基酮戊酸光动力学疗法联合干扰素栓对持续高危型人乳头瘤病毒感染患者病毒清除率及阴道微环境的影响

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中国当代医药 2024年第12期31卷 108-111,116页

作者：唐容迪倪泞沈菲江西省景德镇市第一人民医院产科江西景德镇333000

目的探究5-氨基酮戊酸光动力学疗法(ALA-PDT)联合干扰素栓对持续高危型人乳头瘤病毒(HPV)感染患者HPV清除率及阴道微环境的影响。方法选取2020年1月至2023年1月景德镇市第一人民医院收治的80例持续高危型HPV感染患者作为研究对象,采用... 详细信息

目的探究5-氨基酮戊酸光动力学疗法(ALA-PDT)联合干扰素栓对持续高危型人乳头瘤病毒(HPV)感染患者HPV清除率及阴道微环境的影响。方法选取2020年1月至2023年1月景德镇市第一人民医院收治的80例持续高危型HPV感染患者作为研究对象,采用随机数字表法将其分为对照组和观察组各40例,对照组采用干扰素栓治疗,观察组采用干扰素栓联合ALA-PDT治疗,观察两组病毒载量变化和HPV清除率、菌群密集度、菌群多样性、优势菌情况、阴道pH变化、Nugnet评分变化以及6个月内复发率。结果观察组治疗后的病毒载量低于对照组,HPV清除率高于对照组,差异有统计学意义(P<0.05);观察组治疗后的菌群密集度正常率、菌群多样性正常率、优势菌群健康率均高于对照组,差异有统计学意义(P<0.05);观察组治疗后的阴道pH、Nugnet评分均低于对照组,差异有统计学意义(P<0.05);观察组6个月内复发率低于对照组,差异有统计学意义(P<0.05)。结论ALA-PDT联合干扰素栓治疗持续高危型HPV感染患者可以提高HPV清除率,改善阴道微环境,降低复发率。

关键词：人乳头瘤病毒持续高危型 5-氨基酮戊酸光动力学疗法清除率阴道微环境

Label-free quantitative proteomics analysis models in vivo and in vitro reveal key proteins and potential roles in sciatic nerve injury

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生物细胞(英文) 2023年第9期47卷 2069-2080页

作者： YANG GU MINGGUANG BI DEHUI CHEN ning ni JIANMING CHEN Department of Trauma Orthopedics Surgery Ningbo No.6 HospitalNingbo University School of MedicineNingbo315000China Department of Orthopedics Ningbo Medical CenterLihuili HospitalNingbo University School of MedicineNingbo315000China Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhou350001China School of Medicine Ningbo UniversityNingbo315000China

Background:The underlying mechanism of sciatic nerve injury(Sni)is a common motor functional disorder,necessitates further research.Methods:A rat model of Sni was established,with the injury group subjected to compressive injury of the right sciatic nerve exposed at the midpoint of the thigh and the sham surgery group undergoing the same surgical procedure.An oxygen-glucose deprivation model was employed to simulate in vitro Sni in PC12 cells.Following data acquisition and quality control,differentially expressed proteins(DEPs)in each model were identified through differential analysis,and enrichment analysis was used to explore the potential functions and pathways of the DEPs.Venn diagrams were drawn,and DEPs from both in vivo and in vitro Sni models were imported into the STRING database to construct a protein-protein interaction network and screen for hub proteins.Results:After the peptide segments obtained from rat nerve blockade and PC12 cells met quality requirements,258 DEPs were identified in rat nerve samples,and 119 DEPs were screened in PC12 cells.Enrichment analysis revealed that DEPs in the rat model were predominantly concentrated in biological functions such as myogenic cell proliferation and signaling related to lipid and energy metabolism.DEPs in the in vitro model were mainly enriched in biological processes such as phagocytosis and were associated with lipid transport and metabolism.Two hub proteins,amyloid precursor protein(APP)and fibronectin 1(FN1),were identified through MCC,MCODE,and Degree scoring.Both PC12 cells and external validation sets showed relatively higher expression of APP and FN1 in injured samples.Results of gene set enrichment analysis indicated that these two proteins were associated with metabolic pathways,such as biosynthesis of glycosaminoglycan chondroitin sulfate and biosynthesis of unsaturated fatty acids.Conclusion:APP and FN1 are potential key molecules involved in Sni and are associated with various metabolic pathways in nerve repair.These findings provide a theore

关键词： Oxygen glucose deprivation Proteomics Sciatic nerve injury Peripheral nerve injury

Alternative relay regulates the adenosine triphosphatase activity of Locusta migratoria striated muscle myosin

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Insect Science 2024年第2期31卷 435-447页

作者： Jie Hao Chang Liu ning Zhang Jing Li Tong ni Mingbo Qu Xiang-dong Li State Key Laboratory oflntegrated Management of lnsect Pests and Rodents Insttute of ZoologyChinese Academy of SciencesBejingChina University of Chinese Academy of Sciences BejingChina School of Bioengeering Dalian University of TechnologyDalianChina

Locust(Locusta migratoria)has a single striated muscle myosin heavy chain(Mhc)gene,which contains 5 clusters of alternative exclusive exons and 1 differently included penultimate exon.The alternative exons of Mhc gene encode 4 distinct regions in the myosin motor domain,that is,the N-terminal SH3-like domain,one lip of the nucleotide-binding pocket,the relay,and the converter.Here,we investigated the role of the alternative regions on the motor function of locust muscle myosin.Using Sf9-baculovirus protein expression system,we expressed and purified 5 isoforms of the locust muscle myosin heavy meromyosin(HMM),including the major isoform in the thorax dorsal longitudinal flight muscle(FL1)and 4 isoforms expressed in the abdominal intersegmental muscle(AB1 to AB4).Among these 5 HMMs,FL1-HMM displayed the highest level of actin-activated adenosine triphosphatase(ATPase)activity(hereafter referred as ATPase activity).To identify the alternative region(s)responsible for the elevated ATPase activity of FL1-HMM,we produced a number of chimeras of FL1-HMM and AB4-HMM.Substitution with the relay of AB4-HMM(encoded by exon-14c)substantially decreased the ATPase activity of FL1-HMM,and conversely,the relay of FL1-HMM(encoded by exon-14a)enhanced the ATPase activity of AB4-HMM.Mutagenesis showed that the exon-14a-encoded residues Gly474 and Asn509 are responsible for the elevated ATPase activity of FL1-HMM.Those results indicate that the alternative relay encoded by exon-14a/c play a key role in regulating the ATPase activity of FL1-HMM and AB4-HMM.

关键词： alternative splicing ATPase Locusta migratoria molecular motor muscle myosin

Amorphous electrocatalysts for urea oxidation reaction

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Progress in Natural Science:Materials International 2024年第2期34卷 362-375页

作者： Fenghui Guo Dongle Cheng Qian Chen Hao Liu Zhiliang Wu ning Han Bing-Jie ni Zhijie Chen School of Materials Science and Technology China University of Geosciences Shenzhen Academy of Metrology and Quality Inspection Centre for Technology in Water and Wastewater School of Civil and Environmental Engineering University of Technology Sydney College of Safety and Environmental Engineering Shandong University of Science and Technology Institute of Yellow River Delta Earth Surface Processes and Ecological Integrity Shandong University of Science and Technology Discipline of Chemical Engineering Western Australian School of Mines: Minerals Energy and Chemical Engineering Curtin University Department of Materials Engineering School of Civil and Environmental Engineering The University of New South Wales

Electrochemical urea oxidation reaction(UOR) is a promising alternative to oxygen evolution reaction(OER) for realizing energy-saving hydrogen production. Developing efficient electrocatalysts for UOR becomes a central challenge. Recently, amorphous materials have been extensively used as UOR catalysts because of their numerous defective sites and flexible electronic properties. In this review, recent advancements in the development of amorphous UOR electrocatalysts are analyzed. The UOR mechanism is discussed, and the design of amorphous catalysts is then analyzed. The main catalyst design strategies are illustrated, including nanostructure control,heteroatom doping, composition regulation, and heterostructure construction. Also, electrocatalysts' structureperformance correlation is interpreted. Perspectives in this field are proposed for guiding future studies on the development of high-performance amorphous catalysts towards energy sustainability.

关键词： Catalyst design Component regulation Heteroatom doping Heterostructures Hydrogen energy

GATA3 mutation in a family with hypoparathyroidism,deafness and renal dysplasia syndrome

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World Journal of Pediatrics 2014年第3期10卷 278-280页

作者： Zi-Yang Zhu Qiao-Li Zhou Shi-ning ni Wei Gu Department of Pediatric Endocrinology Nanjing Children's Hospital Affi liated to Nanjing Medical University72 Guangzhou RoadNanjing 210008China

Background:The hypoparathyroidism,deafness and renal dysplasia(HDR)syndrome is an autosomal dominant disorder primarily caused by GATA3 gene mutation.We report here a case that both of a Chinese boy and his father had HDR syndrome which caused by a novel mutation of GATA3.Methods:Polymerase chain reaction and DNA sequencing was performed to detect the exons of the GATA3 gene for mutation analysis.Results:Sequence analysis of GATA3 revealed a heterozygous nonsense mutation in this family:a mutation of GATA3 at exon 2(c.515C>A)that resulted in a premature stop at codon 172(p.S172X)with a loss of two zinc fi nger domains.Conclusion:We identifi ed a novel nonsense mutation which will expand the spectrum of HDR-associated GATA3 mutations.

关键词： HDR syndrome mutation

Genetically Predicted Plasma Levels of Amino Acids and Endometriosis:A Mendelian Randomization Study

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Biomedical and Environmental Sciences 2024年第6期37卷 672-675页

作者： Juanmei Li Yao ni ning Wang Yu Liao Yiwei Yu Wenliang Lyu Ruihua Zhao Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China Department of Dermatovenereology Chengdu Second People’s HospitalChengdu 610021SichuanChina

Endometriosis(EMS)is one of the most common disorders among women of reproductive age and affects approximately 6%–10%of the world total population^([1]).Women with EMS often experience symptoms such as dysmenorrhea,infertility,or difficulties in conceiving.Recent studies focusing on amino acids(AAs)metabolism have shed light on the mechanisms underlying the development and progression of EMS^([2]).

关键词： metabolism infertility Plasma

Characterization and spatial analysis of coseismic landslides triggered by the Luding Ms 6.8 earthquake in the Xianshuihe fault zone, Southwest China

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Journal of Mountain Science 2024年第1期21卷 160-181页

作者： GUO Changbao LI Caihong YANG Zhihua ni Jiawei ZHONG ning WANG Meng YAN Yiqiu SONG Deguang ZHANG Yanan ZHANG Xianbing WU Ruian CAO Shichao SHAO Weiwei Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing 100081China Research Center of Neotectonism and Crustal Stability China Geological SurveyBeijing 100081China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Sichuan Institute of Geological Survey Chengdu 610081China

On September 5, 2022, a magnitude Ms 6.8 earthquake occurred along the Moxi fault in the southern part of the Xianshuihe fault zone located in the southeastern margin of the Tibetan Plateau,resulting in severe damage and substantial economic loss. In this study, we established a coseismic landslide database triggered by Luding Ms 6.8 earthquake, which includes 4794 landslides with a total area of 46.79 km^(2). The coseismic landslides primarily consisted of medium and small-sized landslides, characterized by shallow surface sliding. Some exhibited characteristics of high-position initiation resulted in the obstruction or partial obstruction of rivers, leading to the formation of dammed lakes. Our research found that the coseismic landslides were predominantly observed on slopes ranging from 30° to 50°, occurring at between 1000 m and 2500 m, with slope aspects varying from 90° to 180°. Landslides were also highly developed in granitic bodies that had experienced structural fracturing and strong-tomoderate weathering. Coseismic landslides concentrated within a 6 km range on both sides of the Xianshuihe and Daduhe fault zones. The area and number of coseismic landslides exhibited a negative correlation with the distance to fault lines, road networks, and river systems, as they were influenced by fault activity, road excavation, and river erosion. The coseismic landslides were mainly distributed in the southeastern region of the epicenter, exhibiting relatively concentrated patterns within the IX-degree zones such as Moxi Town, Wandong River basin, Detuo Town to Wanggangping Township. Our research findings provide important data on the coseismic landslides triggered by the Luding Ms 6.8 earthquake and reveal the spatial distribution patterns of these landslides. These findings can serve as important references for risk mitigation, reconstruction planning, and regional earthquake disaster research in the earthquake-affected area.

关键词： Luding earthquake Coseismic landslides Remote sensing interpretation Spatial distribution Xianshuihe fault Earthquake fault