检索结果-南通市图书馆

Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2016年第1期2卷 329-340页

作者： mariangela torniai Silvia Rinaldi Francesca Morgese Giulia Ricci Azzurra Onofri Christian Grohé Rossana Berardi Department of Medical Oncology UniversitàPolitecnica delle Marche60100 AnconaItaly Department of Respiratory Diseases Ev.Lungenklinik BerlinUniversitätsmedizin ChariteLindenberger Weg 2713125 BerlinGermany

Neuroendocrine tumors(NETs)represent a spectrum of rare neoplasms arising in different organism *** on the site of onset,they also can be distinguished using lab exams(secreting ***),clinical symptoms(functioning ***),behavioral,morphological characteristics(tumor cells’architectural growth patterns,mitotic and Ki-67 index,presence of necrosis),and grade of cellular *** aim of this review is to focus on the main signaling pathways targeted by medical treatments of advanced sporadic gastro-entero-pancreatic(GEP)and bronchopulmonary(BP)neuroendocrine *** scientific literature regarding treatment of advanced GEP and BP-NETs has been extensively reviewed using MEDLINE and PubMed databases,selecting principal and more recent research articles,clinical trials,and updated *** analogues represent a valid approach to control symptoms in functioning tumors and to inhibit tumor progression in certain categories on the basis of the typical somatostatin receptor expression observed in *** pathogenesis of NETs has been the subject of increased interest in recent *** driver mutations pathway genes have been identified as important factors in the carcinogenesis process and,therefore,as potential targets for new anticancer *** mutations have been shown in epidermal growth factor receptor,stem cell factor receptor,platelet-derived growth factor receptor,vascular endothelial growth factor,basic-fibroblastic growth factor,transforming growth factor,insulin-like growth factor-1,and their *** M-Tor inhibition pathway modulation has led to the approval of drugs in this field such as *** drugs and several combination regimens with targeted and newer biological agents are being developed and tested in recently conducted and ongoing trials.

关键词： Gastrointestinal and bronchopulmonary neuroendocrine tumors advanced disease medical treatment targeted agents

Locally advanced rectal cancer:The importance of a multidisciplinary approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第46期20卷 17279-17287页

作者： Rossana Berardi Elena Maccaroni Azzurra Onofri Francesca Morgese mariangela torniai Michela Tiberi Consuelo Ferrini Stefano Cascinu Medical Oncology Università Politecnica delle MarcheAzienda OspedalieroUniversitaria Ospedali Riuniti Umberto IGM LancisiG Salesi di Ancona60126 AnconaItaly

Rectal cancer accounts for a relevant part of colorectal cancer cases,with a mortality of 4-10/100000 per *** development of locoregional recurrences and the occurrence of distant metastases both influences the prognosis of these *** the last two decades,new multimodality strategies have improved the prognosis of locally advanced rectal cancer with a significant reduction of local relapse and an increase in terms of overall *** surgery still remains the principal curative treatment and the introduction of total mesorectal excision has significantly achieved a reduction in terms of local recurrence *** employment of neoadjuvant treatment,delivered before surgery,also achieved an improved local control and an increasedsphincter preservation rate in low-lying tumors,with an acceptable acute and late *** review describes the multidisciplinary management of rectal cancer,focusing on the effectiveness of neoadjuvant chemoradiotherapy and of post-operative adjuvant chemotherapy both in the standard combined modality treatment programs and in the ongoing research to improve these regimens.

关键词： Locally advanced rectal cancer Neo-adjuvant treatm

Gastro-entero-pancreatic neuroendocrine tumors:Is now time for a new approach?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2016年第2期7卷 131-134页

作者： Rossana Berardi mariangela torniai Agnese Savini Silvia Rinaldi Stefano Cascinu Department of Medical Oncology Università Politecnica delle Marche

Gastro-entero-pancreatic tumors(GEP-NETs) are rare neoplasms often characterized by an overexpression of somatostatin ***,radiolabeled somatostatin analogues have showed an increasing relevance both in diagnosis and treatment,especially in low-and intermediate-differentiated *** evidences have led to a growing development of new functional imaging techniques as 68 Ga-DOTATATE positron emission tomography/computed tomography(PET/CT) proved useful in the management of these *** these tumors have a heterogeneous behavior also modifying their aggressiveness through *** sometimes 18 F-fluorodeoxyglucose PET/CT appears to be more appropriate to obtain a better assessment of the *** to these considerations,the combination of different functional imaging techniques should be considered in the management of GEP-NETs patients allowing clinicians to choose the tailored therapeutic approach among available options.

关键词： 18F-fluorodeoxyglucose positron emission tomography/computed tomography Gastro-enteropancreatic neuroendocrine tumor 68Ga-DOTATATE positron emission tomography/computed tomography Diagnosis Imaging

Electrolyte disorders in cancer patients: a systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2019年第12期4卷 1-33页

作者： Rossana Berardi mariangela torniai Edoardo Lenci Federica Pecci Francesca Morgese Silvia Rinaldi Clinica Oncologica UniversitàPolitecnica delle MarcheAzienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I-GM Lancisi-G SalesiAncona 60126Italy

Electrolyte disorders are very common complications in cancer patients. They might be associated to a worsening outcome, influencing quality of life, possibility to receive anticancer drugs, and conditioning survival. In fact, they might provoke important morbidity, with dysfunction of multiple organs and rarely causing life-threatening conditions. Moreover, recent studies showed that they might worsen cancer patients' outcome, while a prompt correction seems to have a positive impact. Furthermore, there is evidence of a correlation between electrolyte alterations and poorer performance status, delays in therapy commencement and continuation, and negative treatment outcomes. These alterations usually involve sodium, potassium, calcium, and magnesium serum levels. Several causes might contribute to electrolyte disorders in cancer patients: cancer effects, such as paraneoplastic syndrome of inappropriate antidiuresis and tumor lysis syndrome;anti-cancer therapies;and other concomitant clinical conditions or treatments. However, the origin of the electrolyte disorder is often multifactorial, thus identifying and correcting the causes is not always feasible. Furthermore, they are often not recognized or not considered in clinical practice, worsening these alterations and patient condition. An improvement of knowledge about the physiological mechanisms underlying electrolyte disorders is necessary to strengthen their identification and set up a prompt, adequate, and effective treatment. The aim of this systematic review is to provide an analysis of the pathophysiological mechanisms of electrolyte abnormalities in cancer patients to facilitate their identification, management, and therapy to improve patient outcome.

关键词： Cancer electrolyte disorders hyponatremia syndrome of inappropriate antidiuresis hyperkalemia hypocalcemia hypomagnesemia

Squamous cell carcinoma of the lung: clinical criteria for treatment strategy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2015年第1期1卷 90-93页

作者： Agnese Savini Rossana Berardi Paola Mazzanti Miriam Caramanti Matteo Santoni Mariagrazia De Lisa Francesca Morgese Silvia Rinaldi mariangela torniai Ilaria Fiordoliva Azzurra Onofri Stefano Cascinu Medical Oncology Unit UniversitàPolitecnica delle MarcheAzienda Ospedaliero-Universitaria Ospedali Riuniti60126 AnconaItaly.

Aim:Primary lung cancer is the leading cause of human cancer deaths worldwide,and squamous cell carcinoma(SCC)is one of the most frequent histologic *** aim of our study was to analyze clinical factors potentially affecting the overall outcome of advanced lung SCC ***:A series of 72 consecutive patients with advanced SCC undergoing chemotherapy at our institution between January 2007 and July 2013 were eligible for our ***:By univariate analysis,a better overall survival(OS)was related to response to first-line chemotherapy:median OS were 19.7 vs.7.17 months,respectively,for responders and nonresponders patients(P<0.0001).Eastern Cooperative Oncology Group performance status,gender,and surgery were other prognostic *** signifi cant relationship between OS and smoking status,age,body mass index,or type of treatment was *** the third-line setting,a better OS was associated with objective response to second-line treatment(P=0.015).Conclusion:Our results suggest that differences in OS seem strictly associated with clinical response to previous *** data should be considered in the therapeutic strategy and management of patients with SCC of the lung.

关键词： Non-small cell lung cancer prognostic factors squamous cell carcinoma