Squamous cell carcinoma of the lung: clinical criteria for treatment strategy

作     者：Agnese Savini Rossana Berardi Paola Mazzanti Miriam Caramanti Matteo Santoni Mariagrazia De Lisa Francesca Morgese Silvia Rinaldi Mariangela Torniai Ilaria Fiordoliva Azzurra Onofri Stefano Cascinu 

作者机构：Medical Oncology UnitUniversitàPolitecnica delle MarcheAzienda Ospedaliero-Universitaria Ospedali Riuniti60126 AnconaItaly. 

出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)

年 卷 期：2015年第1卷第1期

页      面：90-93页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Non-small cell lung cancer prognostic factors squamous cell carcinoma 

摘      要：Aim:Primary lung cancer is the leading cause of human cancer deaths worldwide,and squamous cell carcinoma(SCC)is one of the most frequent histologic *** aim of our study was to analyze clinical factors potentially affecting the overall outcome of advanced lung SCC ***:A series of 72 consecutive patients with advanced SCC undergoing chemotherapy at our institution between January 2007 and July 2013 were eligible for our ***:By univariate analysis,a better overall survival(OS)was related to response to first-line chemotherapy:median OS were 19.7 vs.7.17 months,respectively,for responders and nonresponders patients(P0.0001).Eastern Cooperative Oncology Group performance status,gender,and surgery were other prognostic *** signifi cant relationship between OS and smoking status,age,body mass index,or type of treatment was *** the third-line setting,a better OS was associated with objective response to second-line treatment(P=0.015).Conclusion:Our results suggest that differences in OS seem strictly associated with clinical response to previous *** data should be considered in the therapeutic strategy and management of patients with SCC of the lung.