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Inventory of primary emissions of selected persistent organic pollutants to the atmosphere in the area of Great Mendoza

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Emerging Contaminants 2016年第1期2卷 14-25页

作者： david Allende mar.a Florencia Ruggeri beléen Lana Karina Garro Jorgelina Altamirano Enrique Puliafito Universidad Tecnològica nacional Facultad Regional MendozaAtmospheric and Environmental Studies GroupRodriguez 273Argentina

The setting up of a country or region-based inventory is considered a crucial step toward the elimination of worldwide persistent organic pollutants(POPs)***,the need of comparable emission inventories at city or region level is widely recognized to develop evidence-based policies accounting for the relation between emissions and institutional,socio-economic and demographic characteristics at small scale *** to the low spatial and temporal resolution of the available measurements,highly variable air concentrations of several POPs have been observed in Latin American and Caribbean *** paper presents a high resolution spatially disaggregated atmospheric emission inventory for selected POPs in order to assess the environmental fate of some of these compounds in a finer *** study case we estimated releases to air of POPs in a typical mid-size urban conglomeration in *** compounds were total polychlorinated biphenyls(PCBs),total polybrominated diphenyl ethers(PBdEs),total dichlorodiphenyltrichloroethane(ddT)on a sum basis,hexachlorobenzene(HCB)and dioxins and furans(PCdd/Fs),for which emissions were estimated in 0.92 kg/year,1.65 kg/year,4.2E-02 kg/year(total sum of congeners),0.86 kg/year and 4.4E-02 kg/year respectively,values that are in accordance with the geographic and economic *** emitting sources are quite varied,there are very clear trends,particularly in relation to open burning of municipal solid waste and agrochemical use as major ***,the inventory provides valuable data for the analysis of the heterogeneity of POP emissions and the necessary inputs for air quality modeling.

关键词： Atmospheric emission inventory POPs Emission factor Great Mendoza Open burning of municipal solid waste

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Endoscopic submucosal dissection training with pig models in a Western country

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World Journal of Gastroenterology 2010年第23期16卷 2895-2900页

作者： Adolfo Parra-Blanco mar.a Rosa Arnau david nicolás-Pérez Antonio Z Gimeno-García nicolás González Juan A díaz-Acosta Alejandro Jiménez Enrique Quintero department of Gastroenterology University Hospital of the Canary Islands Ofra s/n Endoscopy Unit Department of GastroenterologyAsturias Central University HospitalCelestino Villamil s/n Research Animal Laboratory Ofra s/nLa Laguna University department of Gastroenterology Montevideo Clinic HospitalAvda Italia s/n Research Unit University Hospital of the Canary IslandsOfra s/n

AIM:To test a strategy for endoscopic submucosal dissection(ESd) training in animal models designed to overcome the initial learning ***:ESd was attempted in ex vivo and in vivo pig *** ESd procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was *** the in vivo model,several ESd procedures were performed in up to 3 *** following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESd duration,and ***:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± Sd time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±Sd time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±Sd size of the resected specimens was 45.2±17.8 *** mean±Sd total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not ***:Training in animal models could help endoscopists overcome the learning curve before starting ESd in humans.

关键词： Endoscopic submucosal dissection Training Animal model

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Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions

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World Journal of Clinical Oncology 2019年第10期10卷 318-339页

作者： Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero mar.a Cecilia Guillén-Sacoto Teresa González-Merino Begona Taboada Verónica díaz belén Rubio-Viqueira Ana Aurora díaz-Gavela Francisco Josémarcos Elia del Cerro department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain department of Radiation Oncology Hospital La LuzMadrid 28003Spain Clinical department Faculty of BiomedicineUniversidad EuropeaMadrid 28223Spain department of Radiation Oncology Hospital Fundación Jiménez DíazMadrid 28040Spain department of Medical Oncology Hospital La LuzMadrid 28003Spain department of Radiation Oncology Complexo Hospitalario Universitario Santiago de CompostelaSantiago de Compostela 15706Spain department of Radiation Oncology Hospital Universitario Puerta del MarCádiz 11009Spain department of Medical Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain

Oligometastatic non-small cell lung cancer(nSCLC)describes an intermediate stage of nSCLC between localized and widely-disseminated *** stage of nSCLC is characterized by a limited number of metastases and a more indolent tumor ***,the management of oligometastatic nSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease *** approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative *** optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain *** the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify *** classification will allow us to select the most appropriate therapeutic strategy on an individualized *** the future,the molecular or microRnA profiles will likely improve the treatment selection *** objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic nSCLC,focusing on the role of radiotherapy and *** also discuss areas of controversy and future directions.

关键词： non-small cell lung cancer Metastasectomy Oligometastases Stereotactic ablative radiotherapy Stereotactic body radiation therapy Radiosurgery

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Hepatoprotective effects of antioxidants in chronic hepatitis C

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World Journal of Gastroenterology 2010年第15期16卷 1937-1938页

作者： Ricardo Moreno-Otero mar.a Trapero-marugán digestive diseases Service and CIBEREHd (Instituto de Salud Carlos Ⅲ) University Hospital La Princesa Autonomous University of Ma-drid

We have read with interest the paper published in issue 2, volume 16 of World Journal of Gastroenterology 2010 by nakamura et al, demonstrating that the antioxidant resveratrol (RVT) enhances hepatitis C virus (HCV) replication, consequently, they conclude that RVT is not a suitable antioxidant therapy for HCV chronic infection. The data raise some concern regarding the use of complementary and alternative medicine since the most frequent supplements taken by these patients are antioxidants or agents that may be beneficial for different chronic liver diseases. A recent study by Vidali et al on oxidative stress and steatosis in the progression of chronic hepatitis C concludes that oxidative stress and insulin resistance contribute to steatosis, thus accelerating the progression of fibrosis. We are particularly interested in investigating how the oxidative and nitrosative stress mechanisms are involved in the pathogenesis of different chronic liver diseases.

关键词： Antioxidant Chronic hepatitis C Resveratrol Sadenosylmethionine nitric oxide nacetylcysteine

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Phylofloristics:an example from the Lesser Antilles

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Journal of Plant Ecology 2014年第2期7卷 166-175页

作者： nathan G.Swenson mar.a n.Umaña department of Plant Biology Michigan State UniversityEast LansingMichigan 48824USA

Aims The last decade has seen many plant ecologists integrating phylogenetic analysis into ecology to explain patterns of species cooccurrence and compositional similarity across *** the advances in this area,there are still some challenges that need to be *** challenge is that most of the phylogenetic studies of plant assemblages have focused only on a small proportion of all of the vascular plants that co-occur(*** plants),while much of the remaining co-occurring flora has been *** Here we introduce an analytical approach that we term phylofloristics that analyzes the compositional similarity of floras in relation to spatial and environmental gradients to understand their *** an illustration,we assembled a large phylogenetic tree for the flora of the Lesser Antilles and evaluated the patterns of floristic and phylofloristic similarity among the island-specific *** analyzed the relationship of these similarities with spatial and environmental distance and compared the results for non-endemic and endemic *** Findings The results show a major influence of environmental heterogeneity on the assembly of island floras and far less evidence for the importance of dispersal limitation of lineages and *** study highlights the importance of incorporating broader taxonomic sampling to improve our understanding of assembly processes in *** expect future phylofloristic studies will improve the approach we have taken by generating more refined phylogenetic trees and by incorporating phylogeographic information.

关键词： biogeography Caribbean flora phylogeny plant geography

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dnA and RnA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation

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World Journal of Hepatology 2022年第6期14卷 1182-1189页

作者： Leonardo Lorente Sergio T Rodriguez Pablo Sanz Agustín F González-Rivero Antonia Pérez-Cejas Javier Padilla dácil díaz Antonio González mar.a M martín Alejandro Jiménez Purificación Cerro Julián Portero Manuel A Barrera department ofIntensive Care Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain Intensive Care Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain department of Surgery Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain department of Laboratory Hospital Universitario de CanariasLa Laguna 38320Spain department of digestive Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain Transplant Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain department of Radiology Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain

BACKGROUnd Oxidative damage of dnA and RnA has been associated with mortality of patients with different ***,there is no published data on the potential use of dnA and RnA oxidative damage to predict the prognosis of patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).AIM To determine whether patients with increased dnA and RnA oxidative damage prior to LT for HCC have a poor LT *** Patients with HCC who underwent LT were included in this observational and retrospective *** levels of all three oxidized guanine species(OGS)were measured prior to LT since guanine is the nucleobase that forms dnA and RnA most prone to *** mortality at 1 year was the end-point *** Surviving patients(n=101)showed lower serum OGS levels(P=0.01)and lower age of the liver donor(P=0.03)than non-surviving patients(n=13).An association between serum OGS levels prior to LT and 1-year LT(odds ratio=2.079;95%confidence interval=1.356-3.189;P=0.001)was found in the logistic regression *** The main new finding was that high serum OGS concentration prior to LT was associated with the mortality 1 year after LT in HCC patients.

关键词： dnA oxidative damage Hepatocellular carcinoma Liver transplantation Mortality Oxidized guanine species

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Habitat and food preferences of European rabbits in core and edge populations along the invasion front PatagoniaMonte,Argentina

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Current Zoology 2024年第3期70卷 310-319页

作者： Sabrina Yasmin Bobadilla mar.a A.dacar Fabián M.Jaksic Ricardo A.Ojeda mar.a Fernanda Cuevas Ecología de Mamíferos de Tierras Secas IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina Laboratorio de Filogeografía Taxonomía Integrativa y Ecología(LFTIE)IADIZACCT-Mendoza CONICETAv.Ruiz Leal s/nParque General San MartínMendoza 5500MendozaArgentina Center of Applied Ecology and Sustainability(CAPES) Pontifcia Universidad Católica de ChileAv.Libertador Bernardo O'Higgins 340Santiago 8320000Región MetropolitanaChile

The European rabbit Oryctolagus cuniculus is an exotic herbivorous mammal undergoing an active phase of geographical expansion in the arid ecosystems of *** Adaptive Flexibility Hypothesis states that populations at the range edge(new populations)will exhibit greater fexibility in the use of resources compared with populations located in the range core(older populations).The objective of this work was to compare the rabbit’s use of spatial and trophic resources in relation to the establishment time of their *** sampling was carried out for 2 years(2017 and 2018)in sites with different establishment times for rabbit *** sampling stratifed by type of habitat was applied using 115 fxed strip transects of 1,000 m^(2) laid out across the study *** rabbit signs were recorded in each transect,and environmental and anthropic variables were *** results show that the individuals from the range edge are more selective in the use of habitat than those from the range *** the microhabitat level,we observed a pattern in the particular components of habitat use by rabbits mainly linked to food availability and proximity to *** a trophic perspective,rabbits could show fexible adjustment to novel conditions and environments in the range *** variability in resource use by the European rabbit confrms its ecological fexibility,pivotal for their advance toward new environments in Argentina.

关键词： Arid ecosystems invasive species novel environments range invasion spatial use trophic use

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Experimental bio-artificial liver:Importance of the architectural design on ammonia detoxification performance

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World Journal of Hepatology 2018年第10期10卷 719-730页

作者： mar.a dolores Pizarro mar.a Eugenia Mamprin Lucas damián daurelio Joaquín Valentín Rodriguez mar.a Gabriela Mediavilla Consejo nacional de Investigaciones Científicas y Técnicas(COnICET) Rosario S2002 LRKArgentina Laboratorio de Investigaciones en Fisiología y Biología Molecular Vegetal(LIFiBVe) Facultad de Ciencias AgrariasUniversidad Nacional del LitoralEsperanza 3080Argentina Facultad de Ciencias Bioquímicas y Farmacéuticas Universidad Nacional de RosarioRosario S2002 LRKArgentina Centro Binacional de Criobiología Clínica y Aplicada(CAIC) Universidad Nacional de RosarioRosario S2011 BXNArgentina Instituto de Biología Molecular y Celular de Rosario(IBR CONICET-UNR)Consejo Nacional de Investigaciones Científicas y Tecnológicasy Universidad Nacional de RosarioRosario S2002 LRKArgentina

AIM To determine the influence of the construction design over the biological component's performance in an experimental bio-artificial liver(BAL) *** Two BAL models for liver microorgans(LMOs) were constructed. First, we constructed a cylindrical BAL and tested it without the biological component to establish its correct functioning. Samples of blood and biological compartment(BC) fluid were taken after 0, 60, and 120 min of perfusion. Osmolality, hematocrit, ammonia and glucose concentrations, lactate dehydrogenase(LdH) release(as a LMO viability parameter), and oxygen consumption and ammonia metabolizing capacity(as LMO functionality parameters) were determined. CPSI and OTC gene expression and function were measured. The second BAL, a "flat bottom" model, was constructed using a 25 cm2 culture flask while maintaining all other components between the models. The BC of both BALs had the same capacity(approximately 50 cm3) and both were manipulated with the same perfusion system. The performances of the two BALs were compared to show the influence of *** The cylindrical BAL showed a good exchange of fluids and metabolites between blood and the BC, reflected by the matching of osmolalities, and glucose and ammonia concentration ratios after 120 min of perfusion. no hemoconcentration was detected, the hematocrit levels remained stable during the whole study, and the minimal percentage of hemolysis(0.65% ± 0.10%) observed was due to the action of the peristaltic pump. When LMOs were used as biological component of this BAL they showed similar values to the ones obtained in a normothermic Reoxygenation System(nRS) for almost all the parameters assayed. After 120 min, the results obtained were: LdH release(%): 14.7 ± 3.1 in the BAL and 15.5 ± 3.2 in the nRS(n = 6); oxygen consumption(μmol/min?g wet tissue): 1.16 ± 0.21 in the BAL and 0.84 ± 0.15 in the nRS(n = 6); relative expression of Cps1 and Otc: 0.63 ± 0.12 and 0.67 ± 0.20, respectively,

关键词： Bio-artificial liver Ammonia detoxification device design Ornithine Transcarbamylase Rat liver microorgans Carbamyl Phosphate SynthetaseⅠ

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Risk Factors and Gender differences for depression in Chilean Older Adults:A Cross-Sectional Analysis from the national Health Survey 2016–2017

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International Journal of Mental Health Promotion 2022年第5期24卷 679-697页

作者： Gabriela nazar Carlos-mar.a Alcover Yeny Concha-Cisternas Igor Cigarroa Ximena díaz-martínez mariela Gatica-Saavedra Fabián Lanuza Ana mar.a Leiva-Ordónez mar.a Adela martínez-Sanguinetti Miquel martorell Fanny Petermann-Rocha Claudia Troncoso-Pantoja Carlos Celis-Morales departamento de Psicología Facultad de Ciencias SocialesUniversidad de ConcepciónConcepciónChile Centro de Vida Saludable Universidad de ConcepciónConcepciónChile departamento de Psicología Facultad de Ciencias de la SaludUniversidad Rey Juan CarlosMadridEspaña Pedagogía en Educación Física Facultad de EducaciónUniversidad AutónomaTalcaChile Escuela de Kinesiología Facultad de SaludUniversidad Santo TomásLosÁngelesChile Grupo de Investigación Calidad de Vida Departamento de Ciencias de la EducaciónUniversidad del BiobíoChillánChile depto de Psiquiatría y Salud Mental Facultad de MedicinaUniversidad de ConcepciónConcepciónChile Centro de Epidemiología Cardiovascular y nutricional(EPICYn) Facultad de MedicinaUniversidad de La FronteraTemucoChile Biomarkers and nutrimetabolomics Laboratory Department of NutritionFood Sciences and GastronomyFood Technology Reference Net(XIA)Nutrition and Food Safety Research Institute(INSA)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelona08028Spain Instituto de Anatomía Histología y PatologíaFacultad de MedicinaUniversidad Austral de ChileValdiviaChile Instituto de Farmacia Facultad de CienciasUniversidad Austral de ChileValdiviaChile departamento de nutrición y dietética Facultad de Farmacia.Universidad de ConcepciónConcepciónChile Facultad de Medicina Universidad Diego PortalesSantiagoChile BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgowUK Centro de Investigación en Educación y desarrollo(CIEdE-UCSC).departamento de Salud Pública Facultad de MedicinaUniversidad Católica de la Santísima ConcepciónConcepciónChile Laboratorio de Rendimiento Humano Grupo de Estudio en EducaciónActividad Física y Salud(GEEAFyS)Universidad Católica del MauleTalcaChile

depressive disorders are recognized as one of the most common mental health conditions across different age ***,the risk factors associated with depression among older people from low-and middle-income countries remains *** study aims to identify socio-demographic,health and psychosocial-related factors associated with depression in Chilean older adults.A cross-sectional study was carried out in a representative sample of 1,765 adults aged≥60 years participants from the Chilean national Health Survey 2016–***-sion was assessed with the Composite International diagnostic Interview(CIdI-SF).Associations between the exposure variables and depression were investigated using Poisson regression *** mainﬁndings indi-cated that women showed higher likelihood of depression than men(Prevalence Ratio(PR)=2.6[95%CI:1.40;4.89]).An increased likelihood of depression was found in older adults with chronic pain,multimorbidity(≥2 diseases),previous diagnose of depression,high perception of stress,ﬁnancial stress,and difﬁculties for social *** women,higher likelihood of depression was found for those with the frailty phenotype(PR:8.53[95%CI:1.68;43.32]),rheumatoid arthritis(PR:2.41[95%CI:1.34;4.34]),insomnia(PR:2.99[95%CI:1.74;5.12])and low self-rated well-being(PR:4.94[95%CI:2.26;10.79]).Men who were divorced(PR:7.10[95%CI:1.44;34.90])or widowed(PR:10.83[95%CI:3.71;31.58]),obese(PR:5.08[95%CI:1.48;17.42])and who had asthma(PR:7.60[95%CI:2.31;24.99])were associated with higher odds of *** currentﬁndings may have clinical implications for the early identiﬁcation of older adults more susceptible to depression and also suggest the need to implement cultural and age-sensitive strategies to promote mental health in late life.

关键词： depression older adults aging late-life depression risk factors

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Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta Trinks mar.a F Mascardi Adrián Gadano Sebastián marciano Instituto de Medicina Traslacional e Ingeniería Biomédica-Consejo nacional de Investigaciones Científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo nacional de Investigaciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MASLd)risk *** ability to identify patients with MASLd with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of MASLd biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MASLd clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MASLd biomarker research.

关键词： Metabolic dysfunction-associated steatotic liver disease non-alcoholic steatohepatitis Biomarker Risk stratification Omics

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