Hepatoprotective effects of antioxidants in chronic hepatitis C

作     者：Ricardo Moreno-Otero María Trapero-Marugán 

作者机构：Digestive Diseases Service and CIBEREHD (Instituto de Salud Carlos Ⅲ) University Hospital La Princesa Autonomous University of Ma-drid 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第15期

页      面：1937-1938页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by University Hospital La Princesa Mutua Madrilea Foundation Spain 

主　　题：Antioxidant Chronic hepatitis C Resveratrol Sadenosylmethionine Nitric oxide Nacetylcysteine 

摘      要：We have read with interest the paper published in issue 2, volume 16 of World Journal of Gastroenterology 2010 by Nakamura et al, demonstrating that the antioxidant resveratrol (RVT) enhances hepatitis C virus (HCV) replication, consequently, they conclude that RVT is not a suitable antioxidant therapy for HCV chronic infection. The data raise some concern regarding the use of complementary and alternative medicine since the most frequent supplements taken by these patients are antioxidants or agents that may be beneficial for different chronic liver diseases. A recent study by Vidali et al on oxidative stress and steatosis in the progression of chronic hepatitis C concludes that oxidative stress and insulin resistance contribute to steatosis, thus accelerating the progression of fibrosis. We are particularly interested in investigating how the oxidative and nitrosative stress mechanisms are involved in the pathogenesis of different chronic liver diseases.