DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation

作     者：Leonardo Lorente Sergio T Rodriguez Pablo Sanz Agustín F González-Rivero Antonia Pérez-Cejas Javier Padilla Dácil Díaz Antonio González María M Martín Alejandro Jiménez Purificación Cerro Julián Portero Manuel A Barrera 

作者机构：Department ofIntensive CareHospital Universitario de CanariasLa Laguna 38320TenerifeSpain Intensive Care UnitHospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Department of SurgeryHospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Department of LaboratoryHospital Universitario de CanariasLa Laguna 38320Spain Department of DigestiveHospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Research UnitHospital Universitario de CanariasLa Laguna 38320Spain Transplant UnitHospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Department of RadiologyHospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第6期

页      面：1182-1189页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：DNA oxidative damage Hepatocellular carcinoma Liver transplantation Mortality Oxidized guanine species 

摘      要：BACKGROUND Oxidative damage of DNA and RNA has been associated with mortality of patients with different ***,there is no published data on the potential use of DNA and RNA oxidative damage to predict the prognosis of patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).AIM To determine whether patients with increased DNA and RNA oxidative damage prior to LT for HCC have a poor LT *** Patients with HCC who underwent LT were included in this observational and retrospective *** levels of all three oxidized guanine species(OGS)were measured prior to LT since guanine is the nucleobase that forms DNA and RNA most prone to *** mortality at 1 year was the end-point *** Surviving patients(n=101)showed lower serum OGS levels(P=0.01)and lower age of the liver donor(P=0.03)than non-surviving patients(n=13).An association between serum OGS levels prior to LT and 1-year LT(odds ratio=2.079;95%confidence interval=1.356-3.189;P=0.001)was found in the logistic regression *** The main new finding was that high serum OGS concentration prior to LT was associated with the mortality 1 year after LT in HCC patients.