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neural Regeneration Research 2024年第4期19卷 715-716页

作者： Prakruthi Amar Kumar Jennifer n.Dulin Department of Biology Texas A&M UniversityCollege Station Texas A&m Institute for neuroscience Texas A&M UniversityCollege Station

neural stem and progenitor cell(nSPC)transpla ntation has emerged as a promising therapeutic strategy for replacing lost neuronal populations and repairing damaged neural circuits following nervous system injury and disease.A great deal of experimental work has investigated the biology of nSPC grafting in preclinical animal models;more recently.

关键词： neural system injured

Targeting muscle to treat Charcot-marie-Tooth disease

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neural Regeneration Research 2024年第8期19卷 1653-1654页

作者： David Villarroel-Campos James n.Sleigh Department of neuromuscular Diseases and UCL Queen Square motor neuron Disease Centre UCL Queen Square Institute of NeurologyUniversity College LondonLondonUK UK Dementia Research Institute University College LondonLondonUK

Charcot-marie-Tooth disease(CmT)is a hereditary peripheral neuropathy causing muscle weakness/wasting and sensory dysfunction predominantly in limb *** patients display gait abnormalities,foot deformities,loss of sens... 详细信息

关键词： marie sensation neuropathy

Irisin/BDnF signaling in the muscle-brain axis and circadian system: A review

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The Journal of Biomedical Research 2024年第1期38卷 1-16页

作者： Alexey n.Inyushkin Vitalii S.Poletaev Elena m.Inyushkina Igor S.Kalberdin Andrey A.Inyushkin Department of Human&Animal Physiology Samara National Research UniversitySamara 443011Russia.

In mammals,the timing of physiological,biochemical and behavioral processes over a 24-h period is controlled by circadian *** entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus to a precise 24-h rhythm,environmental zeitgebers are used by the circadian *** is done primarily by signals from the retina via the retinohypothalamic tract,but other cues like exercise,feeding,temperature,anxiety,and social events have also been shown to act as non-photic *** recently identified myokine irisin is proposed to serve as an entraining non-photic signal of *** is a product of cleavage and modification from its precursor membrane fibronectin typeⅢdomain-containing protein 5(FnDC5)in response to *** from well-known peripheral effects,such as inducing the"browning"of white adipocytes,irisin can penetrate the blood-brain barrier and display the effects on the *** data suggest that FnDC5/irisin mediates the positive effects of physical activity on brain *** several brain areas,irisin induces the production of brain-derived neurotrophic factor(BDnF).In the master clock,a significant role in gating photic stimuli in the retinohypothalamic synapse for BDnF is ***,the brain receptor for irisin remains *** the current review,the interactions of physical activity and the irisin/BDnF axis with the circadian system are reconceptualized.

关键词： irisin brain-derived neurotrophic factor peroxisome proliferator-activated receptorγcoactivator 1α circadian rhythm circadian system muscle-brain axis

morphology of crater and caldera lakes in the Far Eastern region of Russia and the features of their development

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Journal of mountain Science 2024年第4期21卷 1246-1258页

作者： Dmitrii n.KOZLOV Ekaterina V.LEBEDEVA Institute of marine Geology and Geophysics Far Eastern Branch of the Russian Academy of SciencesYuzhno-Sakhalinsk 693022Russia Institute of Geography Russian Academy of SciencesMoscow 119017Russia

Volcanic lakes in the Kuril-Kamchatka region are difficult to access,and for this reason,they remain poorly studied,with only scattered and brief data *** authors have conducted a study of 10 lake basins using modern digital echolocation survey techniques and have also compiled and summarized published data for 15 lakes in the region,calculating their main morphometric *** has been established that many caldera lake basins are modified by young explosive funnels,extrusive or effusive domes,and exhibit traces of hydrothermal *** lakes of the same genetic type in the Kuril-Kamchatka region are similar in depth and depression forms,the group of caldera lakes shows less homogeneity across all morphometric *** was found that the absolute heights of the reservoirs on Kamchatka Peninsula are generally greater than those on the Kuril Islands,as is often the case with the size of their *** volcanic lakes under study can rapidly change their volume and shape under the influence of endogenous *** the first time for this region,on the base of repeated observations,underwater extrusive dome rate growth and the approximate rates of 2 lake level changes were *** observations of lakes in the Ksudach calderas(Kamchatka)and on Simushir Island indicate approximate rates of level changes:a decrease ranging within 0.5-0.6 m per year(over a 27-year observation interval)and an increase reaching up to 0.26 m per year(over a 48-year interval).The growth rate of the underwater extrusive dome in Lake Shtyubel has averaged 1-1.6 m per year over the past 25 *** analysis has facilitated the first generalization regarding the morphology and developmental features of crater and caldera lakes in the Kuril-Kamchatka region of Russia,representing an important step in their *** results obtained will provide a solid foundation for subsequent research in this region and may be of interest to researchers studying

关键词： Volcanic lakes Echolocation survey Volcanism Gashydrotherms Kamchatka Kuril Islands

Phase composition,conductivity,and sensor properties of cerium-doped indium oxide

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nano materials Science 2024年第2期6卷 193-200页

作者： m.I.Ikim G.n.Gerasimov V.F.Gromov O.J.Ilegbusi L.I.Trakhtenberg n.n.Semenov Federal Research Center for Chemical Physics of RAS MoscowRussia University of Central Florida OrlandoFLUSA moscow Institute of Physics and Technology(State University) DolgoprudnyMoscow RegionRussia Lomonosov moscow State University MoscowRussia

The hydrothermal synthesis of In_(2)O_(3)and CeO_(2)–In_(2)O_(3)is investigated as well as the properties of sensor layers based on these *** the synthesis of In_(2)O_(3),intermediate products In(OH)_(3)and InOOH are formed,which are the precursors of stable cubic(c-In_(2)O_(3))and metastable rhombohedral(rh-In_(2)O_(3))phases,respectively.A transition from c-In_(2)O_(3)to rh-In_(2)O_(3)is observed with the addition of CeO_(2).The introduction of cerium into rh-In_(2)O_(3)results in a decrease in the sensor response to hydrogen,while it increases in composites based on c-In_(2)O_(3).The data on the sensor activity of the composites correlate with XPS results in which CeO_(2)causes a decrease in the concentrations of chemisorbed oxygen and oxygen vacancies in rh-In_(2)O_(3).The reverse situation is observed in composites based on c-In_(2)O_(3).Compared to In_(2)O_(3)and CeO_(2)–In_(2)O_(3)obtained by other methods,the synthesized composites demonstrate maximum response to H_(2)at low temperatures by 70–100℃,and have short response time(0.2–0.5 s),short recovery time(6–7 s),and long-term stability.A model is proposed for the dependence of sensitivity on the direction of electron transfer between In_(2)O_(3)and CeO_(2).

关键词： Cerium oxide Indium oxide nanocomposite Hydrothermal method Cubic phase Rhombohedral phase Sensor response Conductivity Hydrogen Response/recovery time

Logical Image Acquisition and Analysis of Android Smartphones

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Journal of Computer and Communications 2024年第4期12卷 139-152页

作者： nursel Yalçın Tayfun Yıldırım Department of Computer and Instructional Technologies Education Faculty of Education Gazi University Ankara T&#252rkiye Department of Computer Forensics Institute of Informatics Gazi University Ankara T&#252rkiye

Android smartphones largely dominate the smartphone market. For this reason, it is very important to examine these smartphones in terms of digital forensics since they are often used as evidence in trials. It is possible to acquire a physical or logical image of these devices. Acquiring physical and logical images has advantages and disadvantages compared to each other. Creating the logical image is done at the file system level. Analysis can be made on this logical image. Both logical image acquisition and analysis of the image can be done by software tools. In this study, the differences between logical image and physical image acquisition in Android smartphones, their advantages and disadvantages compared to each other, the difficulties that may be encountered in obtaining physical images, which type of image contributes to obtaining more useful and effective data, which one should be preferred for different conditions, and the benefits of having root authority are discussed. The practice of getting the logical image of the Android smartphones and making an analysis on the image is also included. Although root privileges are not required for logical image acquisition, it has been observed that very limited data will be obtained with the logical image created without root privileges. nevertheless, logical image acquisition has advantages too against physical image acquisition.

关键词： Android Smartphone Forensics Data Acquisition Data Analysis Root Privileges Digital Forensics

Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

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Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad norevik Aleksi m.Huuha Ragnhild n.RФsbjФrgen Linda Hildegard Bergersen Kamilla Jacobsen Rodrigo miguel-dos-Santos Liv Ryan Belma Skender Jose Bianco n.moreira Asgeir Kobro-Flatmoen menno P.Witter nathan Scrimgeour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of neurology and Clinical neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of molecular Inflammation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Centre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(ad).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of ad to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of ad to test whether such plasma impacts cognitive function,amyloid pathology,and ***:mouse hippocampal neuronal cells were exposed to ad-like stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic ad rats(mcGill-R-Thyl-APP)were inj ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(pn amyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did increase hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the ad rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytokines High-intensity interval training Inflammation neurons Plasma transfusion

Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

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marine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.nagahawatta n.m.Liyanage Thilina U.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon Department of marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(mnPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing mnPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 marine natural products Drug targets Inhibitors

Organ Abscission in Plants: With Special Emphasis on Bell Pepper

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1467-1484页

作者： Ramiro Reyes-Castro Héctor G.núñez-Palenius Juan I.Valiente-Banuet maría E.Sosa-morales Blanca E.Orosco-Alcalá Rafael Guzmán-mendoza Graciela m.L.Ruiz-Aguilar Rogelio Costilla-Salazar Life Sciences Division Universidad de GuanajuatoIrapuato36500México School of Engineering and Sciences Tecnologico de MonterreyQuerétaro76130México

Bell pepper(Capsicum annuum L.),along with potato and tomato,is one of the three most cultivated vegetables in the *** pepper is worldwide accepted due to its characteristics of color,smell,ﬂavor,and *** pepper is also considered a nutritious food due to its vitamin and antioxidant *** mexico,bell pepper production has a high value because it is grown for the international markets,particularly the United States of ***,the abscission ofﬂowers and fruits is a factor that limits the yield,hinders the planning of activities,and causes a variation in the prices of *** to the importance of this process,in this work we did a bibliometric analysis and literature review of scientiﬁc advances for the understanding of the abscission pro-cess in plants,and in particular for the bell ***,we introduce new perspectives that would help direct future research about organ abscission in ***,the lack of research that would further clarify abscis-sion process in the bell pepper plant is discussed.

关键词： Capsicum annuum abscission zone plant growth regulators environmental factors

Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez mónica G mendoza-Rodríguez Omar R Alemán Fernando A Candanedo-González miriam Rodríguez-Sosa Juan Josémontesinos-montesinos mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression