Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

作     者：Cecilie Skarstad Norevik Aleksi M.Huuha Ragnhild N.RФsbjФrgen Linda Hildegard Bergersen Kamilla Jacobsen Rodrigo Miguel-dos-Santos Liv Ryan Belma Skender Jose Bianco N.Moreira Asgeir Kobro-Flatmoen Menno P.Witter Nathan Scrimgeour Atefe R.Tari Cecilie Skarstad Norevik;Aleksi M.Huuha;Ragnhild N.Røsbjørgen;Linda Hildegard Bergersen;Kamilla Jacobsen;Rodrigo Miguel-dos-Santos;Liv Ryan;Belma Skender;Jose Bianco N.Moreira;Asgeir Kobro-Flatmoen;Menno P.Witter;Nathan Scrimgeour;Atefe R.Tari

作者机构：Cardiac Exercise Research Group(CERG)Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and Clinical NeurophysiologySt.Olavs University Hospital7030TrondheimNorway Institute of Oral BiologyUniversity of Oslo0372OsloNorway Department of PhysiologyFederal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of Molecular Inflammation ResearchDepartment of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems NeuroscienceCentre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Centre for Alzheimer’s DiseaseNorwegian University of Science and Technology7030TrondheimNorway 

出 版 物：《Journal of Sport and Health Science》 (运动与健康科学（英文）)

年 卷 期：2024年第13卷第2期

页      面：245-255页

核心收录：

学科分类：0403[教育学-体育学] 040302[教育学-运动人体科学(可授教育学、理学、医学学位)] 1202[管理学-工商管理] 04[教育学] 

基　　金：funded by The Norwegian Research Council,the Liaison Committee between the Central Norway Regional Health Authority funded by the Coordination for the Improvement of Higher Education PersonnelBrazil(Capes) 

主　　题：Cytokines High-intensity interval training Inflammation Neurons Plasma transfusion 

摘      要：Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:Mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(McGill-R-Thyl-APP)were inj ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(p0.001)in amyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did increase hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.