Irisin/BDNF signaling in the muscle-brain axis and circadian system: A review
作者机构：Department of Human&Animal PhysiologySamara National Research UniversitySamara 443011Russia.
出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)
年 卷 期：2024年第38卷第1期
页 面：1-16页
核心收录：
学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学]
基 金：supported by the Russian Science Foundation(Grant No.23-25-00152)
主 题：irisin brain-derived neurotrophic factor peroxisome proliferator-activated receptorγcoactivator 1α circadian rhythm circadian system muscle-brain axis
摘 要：In mammals,the timing of physiological,biochemical and behavioral processes over a 24-h period is controlled by circadian *** entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus to a precise 24-h rhythm,environmental zeitgebers are used by the circadian *** is done primarily by signals from the retina via the retinohypothalamic tract,but other cues like exercise,feeding,temperature,anxiety,and social events have also been shown to act as non-photic *** recently identified myokine irisin is proposed to serve as an entraining non-photic signal of *** is a product of cleavage and modification from its precursor membrane fibronectin typeⅢdomain-containing protein 5(FNDC5)in response to *** from well-known peripheral effects,such as inducing thebrowningof white adipocytes,irisin can penetrate the blood-brain barrier and display the effects on the *** data suggest that FNDC5/irisin mediates the positive effects of physical activity on brain *** several brain areas,irisin induces the production of brain-derived neurotrophic factor(BDNF).In the master clock,a significant role in gating photic stimuli in the retinohypothalamic synapse for BDNF is ***,the brain receptor for irisin remains *** the current review,the interactions of physical activity and the irisin/BDNF axis with the circadian system are reconceptualized.
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