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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： lan zhang Jingge Wei Xilei liu Dai li xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan Fang li-Hui li Ming-Qian He Yue Ji Dong-Yan Lu li-Bing zhang Jin-lan Yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,Pliteracy was identified effect on psychological distress among pre-frail older persons(β=-0.307,Pliteracy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

BSA-lysozyme coated NaCa_(2)HSi_(3)O_(9)nanorods on titanium for cytocompatibility and antibacterial activity

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Journal of Materials Science & Technology 2021年第29期88卷 240-249页

作者： Yang xue Jun Chen lan zhang yong Han State-key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong UniversityXi'an 710049China Department of Osteology Xi'an People’s Hospital(Xi'an No.4 Hospital)Xi'an 710100China Department of Osteology Tangdu HospitalFourth Military Medical UniversityXi'an 710038China

Extracellular supplement of Ca and Si accelerates osteogenisis and angiogenisis during bone ***-based ceramics are biodegradable and can release Ca and Si ions ***,locally high alkalinity induced by excessively rapid degradation limits their *** this paper,NaCa_(2)HSi_(3)O_(9)(NCS)nanorods were fabricated on Ti by micro-arc oxidation and hydrothermal treatment;protein layers consisted of different rations of bovine serum albumin(BSA)and lysozyme(LYS)were prepared on NCS nanorods by spinning coating and thermal *** microstructure,ion releasing and wettability of coatings were observed;osteoblast and endotheliocyte behaviors,as well as bacteria response in vitro,were *** protein layer did not change microstructure and phase composition of nanorods but acted as a barrier isolating nanorods from contacting medium,and it results in slowing down the degradation of *** reduced increase of pH value,released Ca and Si ions and incorporation of LYS in BSA protein layer gave NCS nanorods improved MC3 T3-E1 and HUVECs response,compared with ***,the protein layers except pure LYS endowed nanorods with a highly antibacterial effect against staphylococcus aureus and escherichia coli simultaneously,indicating the key role of BSA in resisting antibacterial *** nanorods with BSA and LYS composited protein layers should be a potential coating applied on Ti implants for increasing osseointegration.

关键词： NaCa_(2)HSi_(3)O_(9)nanorods Bovine serum albumin Lysozyme Antibacterial activity Cytocompatibility

Immunomodulation and osteointegration of infected implants by ion-riched and hierarchical porous TiO_(2)matrix

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Nano Research 2023年第2期16卷 2905-2914页

作者： Yang xue lan zhang Fuwei liu liang Kong yong Han State-key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China

Infection is a main cause of implant *** microenvironment cell experiencing after antimicrobial therapy of infected implants is very crucial for immunomodulation and subsequent *** on the superiority of photothermal therapy in anti-infection,a matrix of nanograined TiO_(2)with(Si/P)-dual ions and hierarchical nano/microporous topography is developed on Ti implant by micro-arc *** shows good photothermal properties due to the lattice distortion induced by ion doping and can kill bacteria with near-infrared(NIR)light irradiation *** to the combined action of porous topography and release of Si/P ions,the TiO_(2)matrix achieves M1-to-M_(2)phenotype switch of macrophages timely at different simulating infection stage and accelerates recruitment,proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in *** vivo,the TiO_(2)matrix also shows desired antibacterial performance after photothermal therapy and exhibits outstanding immunomodulatory ability and new bone formation *** study provides a promising TiO_(2)matrix applied in clinic for settling implant infection by NIR light irradiation and promoting bone regeneration through osteoimmunomodulation.

关键词： photothermal antibacterial immunomodulation osteointegration

Si substituted hydroxyapatite nanorods on Ti for percutaneous implants

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Bioactive Materials 2020年第1期5卷 116-123页

作者： Kai li Yang xue Ting Yan lan zhang yong Han State-key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong UniversityXi'an710049China

An ideal intraosseous transcutaneous implant should form a tight seal with soft tissue,besides a requirement of osseointegration at the bone-fixed *** substituted hydroxyapatite(Si-HA)nanorods releasing Si ion and simulating nanotopography of natural tissue were designed on Ti to enhance fibroblast response in vitro and biosealing with soft tissue in ***-HA nanorods were fabricated by alkali-heat treatment followed with hydrothermal *** hydrothermal formation mechanism of Si-HA nanorods was *** surface characteristic of Si-HA nanorods was compared with pure HA *** behaviors in vitro and skin response in vivo on different surfaces were also *** obtained results show that the substitution of Si did not significantly alter the phase component,morphology,roughness and wettability of HA,but additional Si and more Ca were released from Si-HA into *** to pure HA nanrods and Ti substrate,Si-HA nanrods enhanced cell behaviors including proliferation,fibrotic phenotype and collagen secretion in vitro,and reduced epithelial down growth in *** enhanced cell response and biosealing should be due to the releasing of Ca,Si and nanotopography of Si-HA ***-HA nanorods can be a potential coating to accelerate skin integration for percutaneous implants in clinic.

关键词： Si substituted hydroxyapatite Nanorod Biosealing Percutaneous implant

Inhibition force of precipitates for promoting abnormal grain growth in magnetostrictive Fe83Ga17-(B,NbC) alloy sheets

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Rare Metals 2017年第11期36卷 886-893页

作者： Ji-Heng li Wen-lan zhang Chao Yuan xiao-Qian Bao xue-Xu Gao State Key Laboratory of Advanced Metals and Materials University of Science and Technology Beijing 100083 China

Inhibition force of precipitate particles for pro- moting abnormal grain growth in magnetostrictive Feg3Ga17-（B,NbC） alloy sheets was investigated in this study. After a continuous heating and a high-temperature annealing, the Fe83Gat7 ＋ 0.5 at% B alloy sheets do not occur significant abnormal grain growth. Correspondingly, textures of { 111 }〈112〉 and { 100}〈00l〉 in addition to the Goss texture are obtained in the final annealed alloy sheets. By contrast, after the same annealing processes, the size of {110} textured grains is very large in the final annealed Fe83Gaj7 ＋ 0.5 at% NbC alloy sheets due to the abnormal grain growth, which results in a sharp Goss texture. BN precipitates were introduced into Fes3Ga17 ＋ 0.2 at% B alloy sheets by nitriding annealing at 800℃ for 2 min under NH3 atmosphere. The abnormal grain growth of Goss grains is achieved in 0.2 at% B-doped Fe83Ga17 alloy sheets after a high-temperature annealing, which is attributed to the enhanced inhibition force by introducing BN precipitates. During the recrystallization annealing process, Fe2B precipitates is easy to coarsen and decom- pose at high temperature due to the low thermal stability, resulting in a decrease or even disappearance of the inhi- bition force. For NbC and BN precipitates, the thermal stability and hardness of particles are both better than those of Fe2B precipitates, leading to strong inhibition force. Because of the preferred Goss texture, the magnetostriction of 2.05 × 10-4 and 1.81 × 10 4 is obtained in the sec- ondary recrystallized Fe83Gal7 ＋ 0.5 at% NbC and Fes3Gaw ＋ 0.2 at% B alloy sheets, respectively.

关键词： Fe-Ga alloy Magnetostriction Grain growth Inhibition force Precipitates

Microstructure and magnetostrictive performance of NbC-doped <100>oriented Fe-Ga alloys

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International Journal of Minerals,Metallurgy and Materials 2015年第1期22卷 52-58页

作者： Chao Yuan Ji-heng li Wen-lan zhang xiao-qian Bao xue-xu Gao State Key Laboratory of Advanced Metals and Materials University of Science and Technology Beijing

The〈100〉oriented Fe83Ga17 alloy rods with various NbC contents less than 1at%were prepared by the directional solidification method at a growth rate of 720 mm·h^-1. Low NbC-content was found to affect the oriented grain growth and slightly improve the〈100〉ori-entation. Flat grain boundaries in the alloys with low NbC contents less than 0.2at%became greatly curved at higher NbC contents, and a large amount of Nb-rich precipitates were observed in the alloys with high NbC contents. Small amounts of NbC, less than 0.2at%, resulted in an increase in magnetostrictive strain due to the improvement of the〈100〉orientation, and a high magnetostrictive strain value of 335 ×10^-6 under a pre-stress of 15 MPa was obtained in the 0.1at%NbC-doped alloys. The magnetostrictive performance obviously decreased with the NbC addition higher than 0.5at%, and the strain sensitivity under no pre-stress was lower than that in the binary Fe？Ga alloy.

关键词： iron gallium alloys magnetostriction texture niobium carbide directional solidification

Mass production of magnetocaloric LaFeMnSiB alloys with hydrogenation

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Journal of Iron and Steel Research International 2017年第4期24卷 462-468页

作者： Tao zhang Cheng-yong Wang Lugee li yong zhang Cui-lan liu Guangdong University of Technology Guangzhou 510006GuangdongChina Dongguan Eontech Co. Ltd.Dongguan 523662GuangdongChina State Key Laboratory of Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Baotou Research Institute of Rare Earth Baotou 014030Inner MongoliaChina

LaFe_（11.39）Mn_（0.35）Si_（1.26）B_（0.1）Hxalloys were prepared by *** were annealed at 1343Kfor30-90 hto form the NaZn13 ***-rich andα-Fe secondary phases were also *** hydrogenation at 553 Kand 0.15 MPa of H_2 pressure for 5hwas employed to improve the Curie temperature of the alloys to 279 *** maximum magnetic entropy change,relative cooling power,and adiabatic temperature change of LaFe_（11.39）Mn_（0.35）Si_（1.26）B_（0.1）H_x annealed at 1343 Kfor 90hafter hydrogen absorption are 6.38J/（kg·K）（magnetic changesμ0ΔH =1.65T）,100.1J/kg（μ0ΔH =1.65T）,and 2.2 K（μ0ΔH =1.48T）,*** the maximum magnetic entropy change of the LaFe_（11.39）Mn_（0.35）Si_（1.26）B_（0.1）H_x alloys is lower than those of similar alloys with high purity raw materials,the relative cooling power is nearly the *** effect of impurities of the raw materials used was also *** is assumed that the impurity of 0.2wt.% Al is responsible for the reduced entropy change of the resulted *** LaFe_（11.39）Mn_（0.35）Si_（1.26）B_（0.1）H_x alloys prepared by this method could be a low cost alternative material for room temperature magnetic cooling applications.

关键词： Magnetocaloric effect Annealing Hydrogenation Adiabatic temperature change Relative cooling power Maximum magnetic entropy change

Tunable wide-angle multi-band mid-infrared linear-to-linear polarization converter based on a graphene metasurface

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Chinese Physics B 2021年第12期30卷 607-612页

作者： lan-lan zhang Ping li xiao-Wei Song School of Medical Technology and Engineering Henan University of Science and TechnologyLuoyang 471000China

We present a high-efficiency tunable wide-angle multi-band reflective linear-to-linear(LTL)polarization converter,which is composed of an array of two L-shaped graphene patches with different *** the mid-infrared region,the proposed converter can transform x-polarized wave into y-polarized wave at four resonant *** polarization conversion ratios of the four bands reach 94.4%,92.7%,99.3%,and 93.1%,*** carefully choosing the geometric parameter,triple-band LTL polarization conversion can also be *** three polarization conversion ratios reach 91.50%,99.20%,and 97.22%,*** influence of incident angle on the performances of the LTL polarization converter is investigated,and it is found that our polarization converter shows the angle ***,the dynamically tunable properties of the proposed polarization converter are numerically studied by changing Fermi *** the simulation results are conducted by finite element method.

关键词： metasurface graphene polarization converter multi-band