Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

作     者：Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Lan Zhang;Jingge Wei;Xilei Liu;Dai Li;Xiaoqi Pang;Fanglian Chen;Hailong Cao;Ping Lei

作者机构：Haihe Laboratory of Cell EcosystemDepartment of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics InstituteTianjin Medical University General HospitalTianjinChina Department of Gastroenterology and HepatologyTianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of UrologyTianjin Medical University General HospitalTianjinChina Tianjin Neurological InstitutionTianjin Medical University General HospitalTianjinChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第4期

页      面：990-1008页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：supported by the Haihe Laboratory of Cell Ecosystem Innovation Foundation,No.22HHXBSS00047(to PL) Graduate Science and Technology Innovation Project of Tianjin,No.2022BKY173(to LZ) Tianjin Municipal Science and Technology Bureau Foundation,No.20201194(to PL) 

主　　题：age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease 

摘      要：With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.