Si substituted hydroxyapatite nanorods on Ti for percutaneous implants
作者机构：State-key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an710049China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2020年第5卷第1期
页 面：116-123页
核心收录：
学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
基 金：We greatly appreciate the Research Fund for the National Natural Science Foundation of China(Grant number 51771142,51571158 and 51631007) National Key Research and Development Program of China No.2016YFC1100600(sub-project 2016YFC1100604) Natural Science Foundation of Shaanxi Province(No.2019TD-020) Key Research and Development Plan of Shaanxi Province(grant number 2018ZDXMGY119) Key Scientific Research Plan of Shaanxi Provincial Department of Education(grant number 18JC001)for financially supporting this work
主 题：Si substituted hydroxyapatite Nanorod Biosealing Percutaneous implant
摘 要：An ideal intraosseous transcutaneous implant should form a tight seal with soft tissue,besides a requirement of osseointegration at the bone-fixed *** substituted hydroxyapatite(Si-HA)nanorods releasing Si ion and simulating nanotopography of natural tissue were designed on Ti to enhance fibroblast response in vitro and biosealing with soft tissue in ***-HA nanorods were fabricated by alkali-heat treatment followed with hydrothermal *** hydrothermal formation mechanism of Si-HA nanorods was *** surface characteristic of Si-HA nanorods was compared with pure HA *** behaviors in vitro and skin response in vivo on different surfaces were also *** obtained results show that the substitution of Si did not significantly alter the phase component,morphology,roughness and wettability of HA,but additional Si and more Ca were released from Si-HA into *** to pure HA nanrods and Ti substrate,Si-HA nanrods enhanced cell behaviors including proliferation,fibrotic phenotype and collagen secretion in vitro,and reduced epithelial down growth in *** enhanced cell response and biosealing should be due to the releasing of Ca,Si and nanotopography of Si-HA ***-HA nanorods can be a potential coating to accelerate skin integration for percutaneous implants in clinic.
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