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Asian Pacific Journal of Tropical Biomedicine 2017年第7期7卷 619-623页

作者： rooh ullah shafiq ahmed tariq naeem khan nawaz sharif zia ud din khalid mansoor department of pharmacology institute of basic medical sciences khyber medical university

Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino ***: Acute toxicity study was done to check the toxicity of T. aphylla(L. Karst)methanol extract. T. aphylla leaves extract was administered intraperitoneally(100 mg,250 mg and 400 mg/kg body weight per day) to diabetic Wister rats for 21 days. The various parameters were studied including fasting blood glucose levels, haemoglobin and glycosylated ***: The treatment groups with the extract at three dose levels expressively abridged the intensities of blood glucose and Glycosylated Haemoglobin. The earlier detected reduced level of plasma haemoglobin of the diabetic rats was raised to near normalcy with treatment of ***: The results of the current study confirm that the leaves extract of T. aphylla are nontoxic and have antidiabetic nature.

关键词： Tamarix aphylla leaves Diabetes Streptozotocin Antidiabetic potential Insulin secretion

Risk of infection with arboviruses in a healthy population in Pakistan based on seroprevalence

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Virologica Sinica 2024年第3期39卷 369-377页

作者： Shengyao Chen Muhammad Saqib Hafiz Sajid Khan Yuan Bai Usman Ali Ashfaq Muhammad khalid mansoor Abulimti Moming Jing Liu Min Zhou Saifullah Khan Niazi Qiaoli Wu Awais-Ur-Rahman Sial Shuang Tang Muhammad Hassan Sarfraz Aneela Javed Sumreen Hayat Mohsin Khurshid Iahtasham Khan Muhammad Ammar Athar Zeeshan Taj Bo Zhang Fei Deng Ali Zohaib Shu Shen Key Laboratory of Virology and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Faculty of Veterinary Science University of Agriculture FaisalabadFaisalabad 38040Pakistan The Children's Hospital Faisalabad 38000Pakistan Department of Bioinformatics and Biotechnology Government College University FaisalabadFaisalabad 38000Pakistan f Department of Microbiology Faculty of Veterinary and Animal SciencesThe Islamia University of BahawalpurBahawalpur 63100Pakistan Hubei Jiangxia Laboratory Wuhan 430200China Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Armed Forces Institute of Pathology(AFIP) Rawalpindi 46000Pakistan Department of Clinical Studies Faculty of Veterinary&Animal SciencesPir Mehr Ali Shah Arid Agriculture UniversityRawalpindi 46300Pakistan Institute of Microbiology Government College University FaisalabadFaisalabad 38000Pakistan l Atta-ur-Rahman School of Applied Biosciences National University of Science and TechnologyIslamabad 44000Pakistan Department of Clinical Sciences University of Veterinary and Animal SciencesLahore Sub-campusJhang 35200Pakistan Department of Molecular Pathology National Medical Center DHA Phase 1Karachi 75500Pakistan

Infectious diseases caused by arboviruses are a public health concern in ***,studies on data prevalence and threats posed by arboviruses are *** study investigated the seroprevalence of arboviruses in a healthy population in Pakistan,including severe fever with thrombocytopenia syndrome virus(SFTSV),Crimean-Congo hemorrhagic fever virus(CCHFV),Tamdy virus(TAMV),and Karshi virus(KSIV)based on a newly established luciferase immunoprecipitation system(LIPS)assays,and Zika virus(ZIKV)by enzyme-linked immunosorbent assays(ELISA).Neutralizing activities against these arboviruses were further examined from the antibody positive *** results showed that the seroprevalence of SFTSV,CCHFV,TAMV,KSIV,and ZIKV was 17.37%,7.58%,4.41%,1.10%,and 6.48%,respectively,and neutralizing to SFTSV(1.79%),CCHFV(2.62%),and ZIKV(0.69%)were identified,as well as to the SFTSV-related Guertu virus(GTV,0.83%).Risk factors associated with the incidence of exposure and levels of antibody response were ***,co-exposure to different arboviruses was demonstrated,as thirty-seven individuals were having antibodies against multiple viruses and thirteen showed neutralizing ***,individuals aged40 years,and outdoor workers had a high risk of exposure to *** these results reveal the substantial risks of infection with arboviruses in Pakistan,and indicate the threat from co-exposure to multiple *** findings raise the need for further epidemiologic investigation in expanded regions and populations and the necessity to improve health surveillance in Pakistan.

关键词： Arbovirus Pakistan Seroprevalence Tick-borne virus Mosquito-borne virus

Countrywide Survey for MERS-Coronavirus Antibodies in Dromedaries and Humans in Pakistan

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Virologica Sinica 2018年第5期33卷 410-417页

作者： Ali Zohaib Muhammad Saqib Muhammad Ammar Athar Jing Chen Awais-ur-Rahman Sial Saeed Khan Zeeshan Taj Halima Sadia Usman Tahir Muhammad Haleem Tayyab Muhammad Asif Qureshi Muhammad khalid mansoor Muhammad Ahsan Naeem Bing-Jie Hu Bilal Ahmed Khan Ikram Din Ujjan Bei Li Wei Zhang Yun Luo Yan Zhu Cecilia Waruhiu Iahtasham Khan Xing-Lou Yang Muhammad Sohail Sajid Victor Max Corman Bing Yan Zheng-Li Shi CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Ctunese Academy of Sciences Beijing 100049China Faculty of Veterinary Medicine University of AgricultureFaisalabad 38040Pakistan Laboratory of Cancer Biomarkers and Liquid Biopsy College of PharmacyHenan UniversityHenan 475004China Department of Clinical Studies Faculty of Veterinary and Animal SciencesPMAS-Arid Agriculture UniversityRawalpindi 46000Pakistan Dow University of Health Science Pakistan Karachi 74200 Department of Microbiology Government College University FaisalabadFaisalabad 38000Pakistan Livestock and Dairy Development Department(L&DD) Lahore 54000Pakistan College of Veterinary and Animal Sciences The Islamia University of BahawalpurBahawalpur 63100Pakistan State Key Laboratory of Agricultural Mlcroblology Huazhong Agricultural UniversityWuhan 430070China Liaqat University of Medical and Health Science Pakistan Jamshoro 76090 Section of Epidemiology and Public Health Department of Chnical SciencesUniversity of Veterinary and Animal SciencesLahore subcampusJhang 35200Pakistan Institute of Virology Chadte-Universitatsmedizin BerlinCorporate member of Free UniversityHumboldt-University and Berlin Institute of HealthBerlin 10117Germany German Center for Infection Research(DZIF) Berlin 10117Germany

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 776) and serum (n = 1050)samples were collected from camels between November 2015 and February 2018. Samples were collected from animal markets, free-roaming herds and abattoirs. An in-house ELISA was developed to detect IgG against MERS-CoV. A total of 794 camels were found seropositive for MERS-CoV. Prevalence increased with the age and the highest seroprevalence was recorded in camels aged [ 10 years (81.37%) followed by those aged 3.1–10 years (78.65%) and B 3 years (58.19%).Higher prevalence was observed in female (78.13%) as compared to male (70.70%). Of the camel nasal swabs, 22 were found to be positive by RT-qPCR though with high Ct values. Moreover, 2,409 human serum samples were also collected from four provinces of Pakistan during 2016–2017. Among the sampled population, 840 humans were camel *** we found a high rate of MERS-CoV antibody positive dromedaries (75.62%) in Pakistan, no neutralizing antibodies were detected in humans with and without contact to camels.

关键词： Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Camel -Human Pakistan

Analyzing COVID-2019 Impact on Mental Health Through Social Media Forum

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Computers, Materials & Continua 2021年第6期67卷 3737-3748页

作者： Huma Muhammad khalid Sohail Nadeem Akhtar Dost Muhammad Humaira Afzal Muhammad Rafiq Mufti Shahid Hussain mansoor Ahmed Department of Computer Science COMSATS UniversityIslamabad45550Pakistan Department of Management Sciences Bahria Business SchoolBahria UniversityIslamabad44000Pakistan Department of Computer Science&IT The Islamia University of BahawalpurBahawalpur.63100Pakistan Department of Computer Science Bahauddin Zakariya UniversityMultan60800Pakistan Department of Computer Science COMSATS University IslamabadVehari Campus61100Pakistan Department of Computer and Information Science University of OregonEugene97401OregonUSA

This study aims to identify the potential association of mental health and social media forum during the outbreak of COVID-19 ***-19 brings a lot of challenges to government *** the different strategies the most extensively adopted ones were lockdown,social distancing,and isolation among *** people with no mental illness history have been found with high risk of distress and psychological discomfort due to anxiety of being infected with the *** among people due to COVID-19 spread faster than the disease *** misinformation and excessive usage of social media in this pandemic era have adversely affected mental health across the *** to limited historical data,psychiatrists are finding it difficult to cure the mental illness of people resulting from the pandemic repercussion,fueled by social media *** this study the methodology used for data extraction is by considering the implications of social network platforms(such as Reddit)and levering the capabilities of a semi-supervised co-training technique-based use of Naïve Bayes(NB),Random Forest(RF),and Support Vector Machine(SVM)*** experimental results shows the efficacy of the proposed methodology to identify the mental illness level(such as anxiety,bipolar disorder,depression,PTSD,schizophrenia,and OCD)of those who are in anxious of being infected with this *** observed 1 to 5%improvement in the classification decision through the proposed method as compared to state-of-the-art classifiers.

关键词： SARS-CoV-2 mental health social media Reddit machine learning

Analyzing COVID-19 Impact on the Researchers Productivity through Their Perceptions

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Computers, Materials & Continua 2021年第5期67卷 1835-1847页

作者： Syeda Javeria Shoukat Humaira Afzal Muhammad Rafiq Mufti Muhammad khalid Sohail Dost Muhammad Khan Nadeem Akhtar Shahid Hussain mansoor Ahmed Department of Computer Science COMSATS UniversityIslamabad45550Pakistan Department of Computer Science Bahauddin Zakariya UniversityMultan60800Pakistan Department of Computer Science COMSATS University IslamabadVehari CampusIslamabad61100Pakistan Department of Management Studies Bahria Business SchoolBahria UniversityIslamabad44000Pakistan Department of Computer Science&IT The Islamia University of BahawalpurBahawalpur63100Pakistan Department of Computer and Information Science University of OregonEugeneOR97401USA

Context:Since the end of 2019,the COVID-19 pandemic had a worst impact on world’s economy,healthcare,and *** are several aspects where the impact of COVID-19 could be *** these,one aspect is the productivity of researcher,which plays a significant role in the success of an ***:There are several factors that could be aligned with the researcher’s productivity of each domain and whose analysis through researcher’s feedback could be beneficial for decision makers in terms of their decision making and implementation of mitigation plans for the success of an ***:We perform an empirical study to investigate the substantial impact of COVID-19 on the productivity of researchers by analyzing the relevant factors through their *** study aims to find out the impact of COVID-19 on the researcher’s productivity that are working in different *** this study,we conduct a questionnaire-based analysis,which included feedback of 152 researchers of certain *** researchers are currently involved in different research ***,we perform a statistical analysis to analyze the collected responses and report the ***:The results indicate the substantial impact of COVID-19 pandemics on the researcher’s productivity in terms of mental disturbance,lack of regular meetings,and field visits for the collection of primary ***:Finally,it is concluded that researcher’s daily or weekly meetings with their supervisors and colleagues are necessary to keep them more productive in task *** findings would help the decision makers of an organization in the settlement of their plan for the success of an organization.

关键词： COVID-19 researchers productivity statistical analysis

A Systematic Literature Review of Machine Learning and Deep Learning Approaches for Spectral Image Classification in Agricultural Applications Using Aerial Photography

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Computers, Materials & Continua 2024年第3期78卷 2967-3000页

作者： Usman Khan Muhammad khalid Khan Muhammad Ayub Latif Muhammad Naveed Muhammad mansoor Alam Salman A.Khan Mazliham Mohd Su’ud College of Computing and Information Sciences Karachi Institute of Economics and TechnologyKarachi75190Pakistan Faculty of Computing and Informatics(FCI) Multimedia UniversityCyberjaya63100Malaysia Faculty of Computing Riphah International UniversityIslamabad46000Pakistan Faculty of Engineering and Information Technology School of Computer ScienceUniversity of Technology SydneySydneyAustralia

Recently,there has been a notable surge of interest in scientific research regarding spectral *** potential of these images to revolutionize the digital photography industry,like aerial photography through Unmanned Aerial Vehicles(UAVs),has captured considerable *** encouraging aspect is their combination with machine learning and deep learning algorithms,which have demonstrated remarkable outcomes in image *** a result of this powerful amalgamation,the adoption of spectral images has experienced exponential growth across various domains,with agriculture being one of the prominent *** paper presents an extensive survey encompassing multispectral and hyperspectral images,focusing on their applications for classification challenges in diverse agricultural areas,including plants,grains,fruits,and *** meticulously examining primary studies,we delve into the specific agricultural domains where multispectral and hyperspectral images have found practical ***,our attention is directed towards utilizing machine learning techniques for effectively classifying hyperspectral images within the agricultural *** findings of our investigation reveal that deep learning and support vector machines have emerged as widely employed methods for hyperspectral image classification in ***,we also shed light on the various issues and limitations of working with spectral *** comprehensive analysis aims to provide valuable insights into the current state of spectral imaging in agriculture and its potential for future advancements.

关键词： Machine learning deep learning unmanned aerial vehicles multi-spectral images image recognition object detection hyperspectral images aerial photography

Superior and Inferior Gastric Pouch Dilatation Post-Sleeve Surgery: Does Revision Work? A Systematic Review and Case Reports

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Surgical Science 2014年第11期5卷 491-500页

作者： khalid Al Khalifa Fatima AlSaad Budoor Al Musaifer Anwar Al-mansoor Ahmed Al Ansari Department of General Surgery Bahrain Defense Force Hospital Al-Riffa Bahrain Department of Pathology Bahrain Defense Force Hospital Al-Riffa Bahrain Department of Dietetics and Nutrition Bahrain Defense Force Hospital Al-Riffa Bahrain Department of General Surgery Arabian Gulf Universality Manama Bahrain Medical Education Department Royal College of Surgeons of Ireland Busaiteen Bahrain

Longitudinal sleeve gastrectomy (LSG) has become an acceptable option in the management of morbidly obese patients. Complications in the form of pouch dilatation may occur in post-sleeve surgery. However, revision sleeve gastrectomy procedures are effective in correcting such complications. The aim of this study was to systematically review all published cases that reported revision surgeries following the initial sleeve gastrectomy complicated by pouch dilatation. In addition, we are presenting two cases reported from our military/teaching hospital. A systematic literature search was conducted from English-language studies published from 2000 to 2014 from the following databases: PubMed, CINAHL, MEDLINE, EMBASE, Clinical evidence, Dara, Scopus, Web of Sciences, TRIP, Health Technology Database, Cochrane library, and Psych INFO. A total of 5340 articles were identified in the initial search and 5339 articles were excluded based on the exclusion criteria. Only one case study met the inclusion criteria for this systematic review, involving two patients. Also, we are reporting two cases with revision surgery performed for pouch dilatation post-sleeve surgery from our teaching hospital.?There was only one study that reported revision surgery as a management of gastric pouch dilatation post-sleeve surgery. Authors believe that the incidence of revision surgery for the management of pouch dilatation post-sleeve surgery is higher but underreported. This assumption may be valuable, especially because some surgeons consider pouch dilatation post-sleeve surgery a complication that arises due to surgical technique rather than the procedure itself;therefore, it is unreported.

关键词： LSG Gastric Pouch Dilatation BMI Revision Surgery

Stress combination:When two negatives may become antagonistic,synergistic or additive for plants?

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Pedosphere 2023年第2期33卷 287-300页

作者： Hera NADEEM Amir KHAN Rishil GUPTA Mohamed HASHEM Saad ALAMRI mansoor Ahmad SIDDIQUI Faheem AHMAD Department of Botany Aligarh Muslim UniversityAligarh 202002(India) Department of Biology College of ScienceKing Khalid UniversityAbha 61413(Saudi Arabia) Botany and Microbiology Department Faculty of ScienceAssiut UniversityAssiut 71516(Egypt)

Plants in their natural environment are constantly subjected to various abiotic and biotic stressors and,therefore,have developed several defense mechanisms to maintain *** responses are intricate and require various physiological,biochemical,and cellular changes in *** reaction mechanisms in plants subjected to drought,salinity,or heat stress alone have been explained in numerous ***,the field conditions are significantly different from the controlled laboratory *** the field,crops or plants are simultaneously exposed to two or more abiotic and/or biotic stress conditions,such as a combination of salinity and heat,drought and cold,or any of the abiotic stresses combined with pathogen *** have shown that plants’reactions to combinations of more than two stress factors are distinct and cannot be explicitly deduced from their responses to different stresses when applied ***,additional research is needed to understand the complete mechanism of plant responses to stress by analyzing data between single stress and multiple stress *** review aims to provide an overview of current research on plant responses to a combination of various stress conditions and their influence on the metabolic,transcriptional,and physiological characteristics of plants.

关键词： abiotic stress abscisic acid biotic stress defence mechanism multifactorial stress reactive oxygen species stress response

Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages

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World Journal of Gastroenterology 2014年第48期20卷 18390-18396页

作者： Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla Colorectal Research Center Department of Surgery King Saud University Riyadh 11472 Saudi Arabia Department of Pathology King Saud University Riyadh 11472 Saudi Arabia Division of General Surgery Ottawa Hospital University of Ottawa Ontario K1H 8L6 Canada Center for Discovery and Innovation in Parasitic Diseases University of California San Francisco San Francisco CA 94158-2330 United States

AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of ***:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King khalid University *** demographic information,including age and gender,tumor sites,and histological type of CRC,was *** measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal *** transcription and reverse transcription polymerase chain reaction were *** tissue microarrays were constructed to investigate the protein expression of TNF-a by ***:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal *** TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were *** showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of ***:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC.

关键词： Tumor necrosis factor-a Colorectal cancer Real time polymerase chain reaction Immunohistochemistry m RNA