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Role of intravascular ultrasound and optical coherence tomography in intracoronary imaging for coronary artery disease:a systematic review

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Journal of Geriatric Cardiology 2024年第1期21卷 104-129页

作者： Maruf Sarwar Stephen Adedok.n mahesh Anantha Narayanan Department of Cardiovascular Sciences White River HealthBatesvilleARUSA Division of Cardiology University of Tennessee at MemphisTNUSA University of Ark.nsas Medical Sciences Little RockARUSA

Coronary angiography has long been the standard for coronary imaging,but it has limitations in assessing vessel wall anatomy and guiding percutaneous coronary intervention(PCI).Intracoronary imaging techniques lik. intravascular ultrasound(IVUS)and optical coherence tomography(OCT)can overcome these *** uses ultrasound and OCT uses near-infrared light to visualize coronary pathology in unique ways due to differences in temporal and spatial *** techniques have evolved to offer clinical utility in plaque characterization and vessel assessment during ***-analyses and adjusted observational studies suggest that both IVUS and OCT-guided PCI correlate with reduced cardiovascular risk. compared to angiographic guidance *** IVUS demonstrates consistent clinical outcome benefits,OCT evidence is less *** has progressed from early motion detection to high-resolution systems,with smaller compatible *** utilizes near infrared light to achieve unparalleled resolutions,but requires temporary blood clearance for optimal *** visualization and guidance mak. IVUS and OCT well-suited for higher risk.PCI in patients with diabetes and chronic k.dney disease by allowing detailed visualization of complex lesions and ensuring optimal stent deployment and positioning in PCI for patients with type 2 diabetes and chronic k.dney disease,improving *** and recent advancements in zero-and low-contrast OCT techniques can reduce nephrotoxic contrast exposure,thus helping to minimize PCI complications in these high-risk.patient *** and OCT provide valuable insights into coronary pathophysiology and guide interventions precisely compared to angiography *** have comparable clinical outcomes,emphasizing the need for tailored imaging choices based on clinical *** refinement and integration of intravascular imaging will lik.ly play a pivotal role in optimizing coronary interventions and outcomes.

关键词： coronary anatomy limitations

Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation:Evaluating susceptibility to the development of obesity and NAFLD

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Genes & Diseases 2024年第3期11卷 34-38页

作者： MJ mahesh k.mar Shailendra Arindk.r Masum Saini Perumal Nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and Molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk.factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

Techno-Economic Optimization of Novel Stand-Alone Renewable Based Electric Vehicle Charging Station near Bahria Town k.rachi,Sindh Pak.stan

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Energy Engineering 2024年第6期121卷 1439-1457页

作者： Aneel k.mar mahesh k.mar Amir Mahmood Soomro Laveet k.mar Department of Electrical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan Department of Mechanical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan

Electric vehicles (EVs) are the most interesting and innovative technology in the 21st century because of theirenormous advantages, both technically and economically. Their emissions rate compared to fuel-based vehicles isnegligible as they do not consume fuel and hence do not emit any harmful gases. However, their bulk.production,adoption and lack.of charging stations increase the stress of power stations due to modern-day lifestyles. If Electricvehicles demand increases drastically then conventional power stations will not bear their demand and if theygenerate electricity by conventional means it will be very costly and may further add greenhouse gases. Therefore,this research provides the techno-economic assessment of a stand-alone renewable-dependent electric vehiclecharging station, excluding any burden on electrical utility. The proposed study is carried out in Bahria Town,k.rachi, a city in Pak.stan. In this study, HOMER Pro software was utilized for techno-economic assessment. Ahybrid system comprising solar Photovoltaic/Wind Turbine/Fuel cells and battery storage is included in the *** and wind resources were tak.n from NASA’s website, where charging stations will be integrated. The overallresults show promising in terms of total Net Present Cost and the Cost of Energy which are 2.72M $ and 0.237 $,respectively. The total system generation is 3,598 Megawatt hours per year, and the total energy consumption is 885Megawatt hours per year.

关键词： Electrical vehicle techno economic analysis solar energy wind energy hydrogen energy

Effect of pre-twinning and heat treatment on formability of AZX311 Mg alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 1154-1169页

作者： mahesh Panchal Lalit k.ushik.Min-Seong k.m Ravi k.ttan Renganayagalu Shi-Hoon Choi Jaiveer Singh Department of Mechanical Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Department of Metallurgical and Materials Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Energy Materials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang-roSeongbuk-guSeoul 02792Republic of Korea Department of Advanced Components and Materials Engineering Sunchon National University255 Jungang-roSuncheonJeonnam 57922Republic of Korea

In this study,the effects of pre-strain-induced tensile twins(TTWs)and controlled heat treatment on the formability behavior of AZX311 Mg alloy sheets were investigated.A 4%compressive strain was applied to pre-strain the sheets using the in-plane compression(IPC)technique along the rolling direction(RD)to introduce *** pre-strained(PS)samples were subsequently heat-treated at 250℃,350℃,and 400℃ independently for 1 hr,and are termed as PSA1,PSA2,and PSA3,*** cupping tests were conducted to assess the formability of the sheet samples under different initial *** results showed that the PS sample heat-treated at 250℃ for 1hr exhibited a decrease in the Erichsen index(IE)compared to the as-rolled sample,whereas PSA2 and PSA3 samples showed an increase in IE *** analysis revealed that most of the TTWs generated through pre-twinning were stable at 250℃;however,the twin volume fraction reduced to 41%at 350℃ compared to the PS samples due to enhanced thermal activity at that ***,PSA2 samples showed severe grain coarsening in some areas of the sample,and the fraction of such grains increased in the PSA3 *** stretch formability(IE value)of PSA2 samples showed a 32.3%increase compared to the as-rolled ***,the analysis of the deformed specimen at failure under the Erichsen test indicated that considerable detwinning occurs in the PS and PSA1 samples,whereas dislocation slip activity dominates in the PSA2 and PSA3 samples during stretch *** from detwinning and dislocation slip,deformation twins were also observed in all samples after the Erichsen ***,this work.highlights the importance of texture control and its underlying mechanisms via pre-twinning followed by heat treatment and their impact on the room temperature(RT)stretch formability of AZX311 Mg alloy sheets.

关键词： Mg alloys Pre-twinning Texture Formability EBSD.

Amelioration of Aluminium Toxicity in Pigeon Pea [Cajanus cajan (L.) Millsp.] Plant by 24-Epibrassinolide

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American Journal of Plant Sciences 2016年第12期7卷 1618-1628页

作者： N. Divya Sri M. Madhan Mohan k. mahesh k. Raghu S. Seeta Ram Rao Department of Botany Osmania University Hyderabad India

The effect of 24-epibrassinolide on growth of pigeon pea [Cajanus cajan (L.) Millsp.] under aluminium toxicity was studied. 24-EBL reduced the impact of Al stress on plant growth. Particularly 24-EBL reduced the inhibitory impact of aluminium toxicity on root growth which was further manifested in overall improvement of vegetative growth. Application of 24-epibrassinolide removed the inhibitory influence of Al nodulation. The growth stimulation in Cajanus plants by 24-EBL under Al stress was associated with elevated levels of chlorophylls, nucleic acids and soluble proteins. 24-Epibrassinolide application enhanced proline content in Al3+ stressed Cajanus plants. Further, the supplementation of 24-epibrassinolide to Al stress treatments increased the activities of antioxidative enzymes viz., catalase [EC 1.***.1.6];peroxidase [EC 1.***.1.7];superoxide dismutase [EC 1.***.1.1] and ascorbate peroxidase [EC 1.***.1.11]. Lipid peroxidation induced by Al was found reduced with the supplementation of 24-epibrassinolide. The present studies demonstrated the ameliorating capability of 24-epibrassinolide on the Al induced inhibition of plant growth of C. cajan.

关键词： Aluminium Toxicity 24-Epibrassinolide Cajanus cajan Antioxidative Enzymes

Enhancing Software Effort Estimation:A Hybrid Model Combining LSTM and Random Forest

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Journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 42-51页

作者： Badana mahesh Mandava k.anthi k.ran Department of Computer Science and Engineering GITAM Deemed to be UniversityVishakhapatnam 561203India Department of Computer Science and Engineering Anil Neerukonda Institute of Technology&SciencesVishakhapatnam 531162India

Effort estimation plays a crucial role in software development projects,aiding in resource allocation,project planning,and risk.*** estimation techniques often struggle to provide accurate estimates due to the complex nature of software *** recent years,machine learning approaches have shown promise in improving the accuracy of effort estimation *** study proposes a hybrid model that combines Long Short-Term Memory(LSTM)and Random Forest(RF)algorithms to enhance software effort *** proposed hybrid model tak.s advantage of the strengths of both LSTM and RF *** evaluate the performance of the hybrid model,an extensive set of software development projects is used as the experimental *** experimental results demonstrate that the proposed hybrid model outperforms traditional estimation techniques in terms of accuracy and *** integration of LSTM and RF enables the model to efficiently capture temporal dependencies and non-linear interactions in the software development *** hybrid model enhances estimation accuracy,enabling project managers and stak.holders to mak. more precise predictions of effort needed for upcoming software projects.

关键词： software effort estimation hybrid model ensemble learning LSTM temporal dependencies non⁃linear relationships

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40-meter-long REBCO tapes with critical current over 4,000 A/12 mm at 4.2 k.and 13 T by advanced MOCVD

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Superconductivity 2024年第1期9卷 29-34页

作者： mahesh Paidpilli Chirag Goel Bhabesh Sarangi Siwei Chen Eduard Galstyan Jan Jaroszynsk. Griffin Bradford Dmytro Abraimov Venk.t Selvamanick.m Department of Mechanical Engineering Advanced Manufacturing InstituteTexas Center for SuperconductivityUniversity of HoustonHoustonTexasUSA AMPeers LLC HoustonTexasUSA National High Magnetic Field Laboratory TallahasseeFloridaUSA

REBa_(2)Cu_(3)O_(7−δ)(REBCO,RE=rare earth)tapes doped with 5%and 15%Zr have been scaled up to lengths more than 40 m in a pilot‐scale advanced metal organic chemical vapor deposition(A‐MOCVD)*** precursor compositions used for the long tapes were guided by a study of the influence of(Ba+dopant)/Cu content on the critical current density(Jc)of 5 and 15 mol.%Hf‐and Zr‐added tapes at 4.2 k.and 13 *** 40‐mlong tapes exhibited a critical current(Ic)over 4,000 A/12 mm at 4.2 k.and 13 T as well as over 1,400 A/12 mm at 20 k.and 20 *** critical current densities of a 40‐m‐long tape doped with 5%Zr at 4.2 k.measured at the National High Magnetic Field Laboratory(NHMFL)were>10 MAcm^(−2)and>5 MAcm^(−2)at 14 T and 30 T,respectively,which are over three times those of commercial REBCO *** infield Jc of 5%Zradded 40‐m‐long tapes was similar to those of previously‐reported high‐performance short samples made with 15%Zr or *** results demonstrate the excellent potential of A‐MOCVD for manufacturing high Ic REBCO tapes for use in ultrahigh‐field magnet applications.

关键词： High‐temperature superconductors MOCVD REBCO Critical current

Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok.Jangra Priyank. Gola Jiten Singh Pooja Gond Swarnabha Ghosh mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz k.mal Punya Sachdeva Saurabh k.mar Jha Shreesh Ojha Dinesh k.mar Niraj k.mar Jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitk.ra College of Pharmacy Chitkara UniversityPunjabIndia Uk. Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro k.,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

Honey vesicle-lik. nanoparticles protect aged liver from non-alcoholic steatohepatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh Nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia Bao Nguyen Prak.sh k.mar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.k.chman Bara Altartouri Guoqing Lu Sathish k.mar Natarajan mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi k.y Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelik. nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly tak.n up by k.pffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-k.ppa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-k. ***,oral intak. of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis