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Iron, Dopamine, and α-Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson's Disease

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Neuroscience Bulletin 2018年第2期34卷 382-384页

作者： Ning Song junxia xie Department of Physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology Medical College of Qingdao University Institute of Brain Science and Disease Qingdao University

Parkinson’s disease(PD)is recognized as the second most common neurodegenerative disorder after Alzheimer *** a fascinating 200-year journey of research has revealed the multifaceted nature of PD[1,2],its fundamental features are the loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc)and depletion of dopamine(DA)in the *** accumulates in normal brains with ***

关键词： In Synuclein Interactions in at-Risk Dopaminergic Neurons in Parkinson’s Disease and Dopamine

Neuroprotective Effects of Brain-Gut Peptides: A Potential Therapy for Parkinson’s Disease

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Neuroscience Bulletin 2019年第6期35卷 1085-1096页

作者： Dong Dong junxia xie Jun Wang Department of Physiology and Pathophysiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders and State Key Disciplines: Physiology Medical College of Qingdao University

Parkinson's disease(PD) is the second most common neurodegenerative disease and is typically associated with progressive motor and non-motor ***, dopamine replacement therapy is mainly used to relieve the motor symptoms, while its long-term application can lead to various complications and does not cure the disease. Numerous studies have demonstrated that many brain-gut peptides have neuroprotective effects in vivo and in vitro, and may be a promising treatment for PD. In recent years, some progress has been made in studies on the neuroprotective effects of some newly-discovered braingut peptides, such as glucagon-like peptide 1, pituitary adenylate cyclase activating polypeptide, nesfatin-1, and ghrelin. However, there is still no systematic review on the neuroprotective effects common to these peptides. Thus,here we review the neuroprotective effects and the associated mechanisms of these four peptides, as well as other brain-gut peptides related to PD, in the hope of providing new ideas for the treatment of PD and related clinical research.

关键词： Parkinson's disease Glucagon-like peptide 1 Pituitary adenylate cyclase activating polypeptide Nesfatin-1 Ghrelin

Axonal Iron Transport might Contribute to Iron Deposition in Parkinson’s Disease

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Neuroscience Bulletin 2021年第2期37卷 275-277页

作者： Leilei Chen Chong Li junxia xie Institute of Brain Science and Disease Shandong Provincial Collaborative Innovation Center for Neurodegenerative DisordersShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersQingdao UniversityQingdao 266071China

More and more evidence has suggested that iron deposition in the substantia nigra,which is correlated with motor and cognitive dysfunction,is an important trigger factor,potential biomarker,and therapeutic target for Parkinson's disease(PD)[1-3].Although the cellular mechanisms of nigral iron deposition have been well investigated,the exactly mechanisms,especially the origin of the increased nigral iron,have not been fully elucidated.

关键词： therapeutic exactly Iron

Expanding Views of Mitochondria in Parkinson's Disease: Focusing on PINK1 and GBA1 Mutations

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Neuroscience Bulletin 2022年第7期38卷 825-828页

作者： Yu Yuan Xizhen Ma Ning Song junxia xie Institute of Brain Science and Disease School of Basic MedicineShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersQingdao UniversityQingdao 266071China

A new conceptual model has been proposed for Parkinson's disease(PD)pathogenesis,which can be divided into triggering,facilitating,and aggravating processes[1].Mitochondria are believed to participate in all three pha... 详细信息

关键词： pathogenesis Mitochondria Focus

Alpha-Synuclein Handling by Microglia: Activating, Combating,and Worsening

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Neuroscience Bulletin 2021年第5期37卷 751-753页

作者： Ning Song Leilei Chen junxia xie Department of Physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersSchool of Basic MedicineQingdao UniversityQingdao 266071China Institute of Brain Science and Disease Qingdao University<Qingdao 266071China

Neuroinflammation and a-synuclein (a-syn) aggregation are both neuropathological hallmarks of Parkinson’s disease (PD). Microglia are crucial participants in eliciting neuroinflammatory responses themselves, as well as modulating neurotoxic activity in astrocytes, therefore forming a pathway to neurodegeneration induced by both central and peripheral insults [1, 2].

关键词： Alpha inflammation Combat

Targeting the Cuneiform Nucleus in Parkinson’s Disease: Option to Improve Locomotor Activity

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Neuroscience Bulletin 2022年第8期38卷 976-978页

作者： Wei Cui Bao Xue junxia xie Huamin Xu Department of Physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersSchool of Basic MedicineQingdao UniversityQingdao266071China Institute of Brain Science and Disease Qingdao UniversityQingdao266071China

Parkinson's disease(PD)is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta(SNpc),accompanied by severe locomotor deficits[1].Deep brain stimulation(DBS)mainly targeting the subthalamic nucleus and the internal segment of the globus pallidus has now been clinically used to improve the motor symptoms of PD ***,these targets do not relieve the serious postural instability and freezing of *** mesencephalic locomotor region(MLR)plays a key role in controlling locomotion[2,3].

关键词： stimulation freezing clinically

Linking Genetic Risks to Pathologicalα-Synuclein Transmission in Parkinson's Disease

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Neuroscience Bulletin 2023年第7期39卷 1186-1188页

作者： Xiaoqing Mi Lei Chen junxia xie Ning Song Department of Physiology School of Basic MedicineInstitute of Brain Science and DiseaseShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersQingdao UniversityQingdao 266071China

Misfoldedα-synuclein(α-syn)hallmarks the neuropathological characteristics of Parkinson's disease(PD)and acts as a"pathological seed"that promotes the progression of the disease[1].About 15%of PD patients have a family history,5%-10%have a monogenic disorder with a Mendelian pattern of inheritance[2],and>90 independent risk signals identified by genome-wide association studies(GWASs)can be used to explain the non-monogenic risk of PD[3].

关键词： patients Pathological pattern

Astrocyte dysfunction in Parkinson's Check for updates disease:from the perspectives of transmittedα-synuclein and genetic modulation

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Translational Neurodegeneration 2021年第4期10卷 519-535页

作者： Changjing Wang Tongtong Yang Meiyu Liang junxia xie Ning Song Department of Physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersSchool of Basic MedicineQingdao UniversityQingdao 266071China Institute of Brain Science and Disease Qingdao UniversityQingdao 266071China

Parkinson's disease(PD)is a common neurodegenerative disorder that primarily affects the *** the etiology of PD is likely multifactorial with the involvement of genetic,environmental,aging and other factors,α-synuclein(α-syn)pathology is a pivotal mechanism underlying the development of *** recent years,astrocytes have attracted considerable attention in the *** astrocytes perform a variety of physiological functions in the brain,they are pivotal mediators ofα-syn toxicity since they internalizeα-syn released from damaged neurons,and this triggers an inflammatory response,protein degradation dysfunction,mitochondrial dysfunction and endoplasmic reticulum *** are indispensable coordinators in the background of several genetic mutations,including PARK7,GBA1,LRRK2,ATP13A2,PINK1,PRKN and *** the most abundant glial cells in the brain,functional astrocytes can be replenished and even converted to functional *** this review,we discuss astrocyte dysfunction in PD with an emphasis onα-syn toxicity and genetic modulation and conclude that astrocyte replenishment is a valuable therapeutic approach in PD.

关键词： Parkinson's disease Astrocytes Genetic mutation α-synuclein Therapeutics

Potassium Channels: A Potential Therapeutic Target for Parkinson's Disease

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Neuroscience Bulletin 2018年第2期34卷 341-348页

作者： Xiaoyan Chen Bao Xue Jun Wang Haixia Liu Limin Shi junxia xie Collaborative Innovation Center for Brain Science Department of Physiology Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders Key Laboratory of Pathogenesis and Prevention of Neurological Disorders Medical College of Qingdao University

The pathogenesis of the second major neurodegenerative disorder, Parkinson’s disease(PD), is closely associated with the dysfunction of potassium(K~+ ) channels. Therefore, PD is also considered to be an ion channel disease or neuronal channelopathy. Mounting evidence has shown that K~+ channels play crucial roles in the regulations of neurotransmitter release, neuronal excitability, and cell volume. Inhibition of K~+ channels enhances the spontaneous firing frequency of nigral dopamine(DA)neurons, induces a transition from tonic firing to burst discharge, and promotes the release of DA in the ***, three K~+ channels have been identified to protect DA neurons and to improve the motor and non-motor symptoms in PD animal models: small conductance(SK)channels, A-type K~+ channels, and KV7/KCNQ *** this review, we summarize the physiological and pharmacological effects of the three K~+ channels. We also describe in detail the laboratory investigations regarding K~+ channels as a potential therapeutic target for PD.

关键词： Parkinson’s disease A-type K+ channels SK channels KV7/KCNQ channels Dopamine