Dopamine in Parkinson's Disease: Precise Supplementation with Motor Planning

作     者：Leilei Chen Junxia Xie 

作者机构：Institute of Brain Science and Disease Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders Qingdao University 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2018年第34卷第5期

页      面：873-874页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(81430024 and31771124) the China Postdoctoral Science Foundation(2017M622128) Qingdao Postdoctoral Research Project Shandong Province Medical and Health Science and Technology Development Project(2017WS121) 

主　　题：PD Precise Supplementation with Motor Planning Dopamine in Parkinson’s Disease 

摘      要：Parkinson＇s disease （PD） is the second most common neurodegenerative disorder which mainly affects the motor system. The pathological characteristics of PD include the loss of dopaminergic neurons in the substantia nigra region and dopamine depletion in the striatum. Dopamine functions as a neurotransmitter that is involved in motor control, executive functions, motivation, arousal, reinforcement, and reward [1]. The ongoing tonic levels of dopamine release in the dorsal striatum are thought to be important for the regulation of movement. Because of the dopamine depletion in the striatum, movement is affected in PD. The typical motor symptoms consist of poverty of movement, tremor at rest, rigidity, and postural instability. Meanwhile, pre-motor symptoms, including hyposmia, constipation, depression, and REM sleep behavior disorder, have been suggested to precede these typical motor symptoms by years [2]. It is usually proposed to alleviate these symptoms via boosting the levels of dopamine in PD. However, this may not be the case.