Expanding Views of Mitochondria in Parkinson's Disease: Focusing on PINK1 and GBA1 Mutations

作     者：Yu Yuan Xizhen Ma Ning Song Junxia Xie Yu Yuan;Xizhen Ma;Ning Song;Junxia Xie

作者机构：Institute of Brain Science and DiseaseSchool of Basic MedicineShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersQingdao UniversityQingdao 266071China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2022年第38卷第7期

页      面：825-828页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

基　　金：This insight article,was,supportedby the National Natural Science Foundation of China(32170984 and 31871049) the Excellent Innovative Team of Shandong Province the Taishan Scholars Construction Project. 

主　　题：pathogenesis Mitochondria Focus 

摘      要：A new conceptual model has been proposed for Parkinson s disease(PD)pathogenesis,which can be divided into triggering,facilitating,and aggravating processes[1].Mitochondria are believed to participate in all three phases:pesticides(one of the definite triggers in PD pathogenesis)inhibit mitochondrial complex I(MCI).