Alpha-Synuclein Handling by Microglia: Activating, Combating,and Worsening

作     者：Ning Song Leilei Chen Junxia Xie Ning Song;Leilei Chen;Junxia Xie

作者机构：Department of PhysiologyShandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological DisordersSchool of Basic MedicineQingdao UniversityQingdao 266071China Institute of Brain Science and DiseaseQingdao University

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2021年第37卷第5期

页      面：751-753页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071006[理学-神经生物学] 

基　　金：supported by grants from the National Foundation of Natural Science of China (31871049  31771124  and 31800893)。 

主　　题：Alpha inflammation Combat 

摘      要：Neuroinflammation and a-synuclein (a-syn) aggregation are both neuropathological hallmarks of Parkinson’s disease (PD). Microglia are crucial participants in eliciting neuroinflammatory responses themselves, as well as modulating neurotoxic activity in astrocytes, therefore forming a pathway to neurodegeneration induced by both central and peripheral insults [1, 2].