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Phytohormone dynamics in developing endosperm influence rice grain shape and quality

Journal of Integrative Plant Biology 2020年第10期62卷 1625-1637页

作者： Xiao-Fan Zhang jian-Hua tong Ai-Ning Bai Chun-Ming Liu Lang-Tao Xiao Hong-Wei Xue School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Hunan Provincial Key Laboratory of Phytohormones and Growth Development Hunan Agricultural UniversityChangsha 410128China Key Laboratory of Plant Molecular Physiology Institute of Botanythe Chinese Academy of SciencesBeijing 100093China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Joint Center for Single Cell Biology/School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and Ecologythe Chinese Academy of SciencesShanghai 200032China

Hormones are important signaling molecules regulating developmental processes and responses to environmental stimuli in higher *** endosperm,the portion of the seed surrounding the embryo,is the main determinant of rice grain shape and yield;how-ever,the dynamics and exact functions of phyto-hormones in developing endosperm remain *** a systemic study including transcriptome analysis,hormone measurement,and transgene-based endosperm-specific expression of phytohormone bio-synthetic enzymes,we demonstrated that dynamic phytohormone levels play crucial roles in the developing rice endosperm,particularly in regard to grain shape and *** detected diverse,differential,and dra-matically changing expression patterns of genes related to hormone biosynthesis and signaling during endosperm development,especially at early devel-opmental *** chromatography measure-ments confirmed the dynamic accumulation of hor-mones in developing *** transgenic analysis performed on plants expressing hormone bio-synthesis genes driven by an endosperm-specific pro-moter revealed differential effects of the hormones,especially auxin and brassinosteroids,in regulating grain shape and *** studies help elucidate the dis-tinct roles of hormones in developing endosperm and provide novel and useful tools for influencing crop seed shape and yield.

关键词： fir grain shape

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Ash removal from inferior coal via ammonium fluoride roasting and simultaneous yield of white carbon black

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International Journal of Mining Science and Technology 2024年第2期34卷 261-279页

作者： Xuqin Duan Shuaiyu Lu Yuxiao Fu Jiazhe Zhang tong Liu jian Ma School of Civil and Resource Engineering University of Science&Technology BeijingBeijing 100083China State Key Laboratory for Efficient Mining of Metal Mines University of Science&Technology BeijingBeijing 100083China China Coal Processing and Utilizaiton Association Beijing 100013China

The quality upgrading and deashing of inferior coal by chemical method still faces great *** dangers of strong acid,strong alkali,waste water and exhaust gas as well as high cost limit its industrial *** paper systematically investigates the ash reduction and desilicification of two typical inferior coal utilizing ammonium fluoride roasting *** the optimal conditions,for fat coal and gas coal,the deashing rates are 69.02%and 54.13%,and the desilicification rates are 92.64%and 90.27%,*** molar dosage of ammonium fluoride remains consistent for both coals;however,the gas coal,characterized by a lower ash and silica content(less than half that of the fat coal),achieves optimum deashing effect at a reduced time and *** majority of silicon in coal transforms into gaseous ammonium fluorosilicate,subsequently preparing nanoscale amorphous silica with a purity of 99.90%through ammonia *** of the fluorine in deashed coal are assigned in inorganic minerals,suggesting the possibility of further fluorine and ash removal via *** research provides a green and facile route to deash inferior coal and produce nano-scale white carbon black simultaneously.

关键词： Inferior coal Deashing treatment Silicon recycling Ammonium fluoride roasting White carbon black

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青稞生长发育规律研究

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西藏农业科技 2024年第1期46卷 16-20页

作者：谈建鑫罗黎鸣同坚米玛更才关卫星西藏自治区农牧科学院农业研究所/省部共建青稞和牦牛种质资源与遗传改良国家重点实验室西藏拉萨850032 西藏山南市浪卡子县农牧综合服务中心西藏浪卡子851100

为掌握冬青稞和春青稞生长发育规律和差异,预测冬青稞和春青稞生长发育进程,进而为青稞育种、高产栽培、区域产量预测提供数据支持,以西藏生产上主推的冬青稞和春青稞品种“冬青18”和“藏青3000”为研究对象,研究了冬春青稞关键生育期... 详细信息

为掌握冬青稞和春青稞生长发育规律和差异,预测冬青稞和春青稞生长发育进程,进而为青稞育种、高产栽培、区域产量预测提供数据支持,以西藏生产上主推的冬青稞和春青稞品种“冬青18”和“藏青3000”为研究对象,研究了冬春青稞关键生育期的叶面积指数、单株根数、单株平均根长、单株总根长、生物量积累和分配等指标的变化规律,较为系统地研究青稞生长发育规律。结果表明:冬青稞生育期远高于春青稞,春青稞各个生育期叶面积指数高于冬青稞;冬青稞较春青稞能形成较为发达的根系;冬青稞各个生育期生物量干重和鲜重均高于春青稞。

关键词：青稞生长发育规律

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QSAR Study and Molecular Design of Isoquinolone Derivative JNK1 Inhibitors

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Chinese Journal of Structural Chemistry 2021年第12期40卷 1586-1594,1551页

作者： tong jian-Bo XIAO Xue-Chuna LUO Ding XU Hai-Yin WANG Jie College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi'an 710021China Shaanxi Key Laboratory of Chemical Additives for Industry Xi'an 710021China

JNK1 is a drug target for the treatment of type 2 diabetes,and it plays a key mediator role in metabolic *** this paper,holographic quantitative structure-activity relationship(HQSAR)technology and Topomer comparative molecular field analysis(Topomer CoMFA)technology are used to analyze the quantitative structure-activity relationship(QSAR)of 39 isoquinolone *** cross validation correlation coefficient(q^(2))is 0.696(Topomer CoMFA)and 0.826(HQSAR),and the non-cross validation correlation coefficient(r^(2))is 0.935(Topomer CoMFA)and 0.987(HQSAR).The results showed that the models have good stability and predictive *** Topomer search module was applied to define high contribution fragments in the ZINC database,designing 20 new isoquinolone compounds with theoretically high inhibitory *** molecular docking was carried out to explore the interaction between the ligand and target JNK1 *** study can provide a theoretical basis for the design of new JNK1 inhibitors.

关键词： Topomer CoMFA HQSAR molecular docking isoquinolone derivatives molecular design

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Influence of gravel content and cement on conglomerate fracture

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Petroleum Science 2023年第3期20卷 1724-1741页

作者： Zhen-Xin Zhang Hong-Kui Ge Jjian-Bo Wang jian-tong Liu Dun-Qing Liu Wei-Wei Teng Ying-Hao Shen Unconventional Oil and Gas Technology Research Institute China University of Petroleum(Beijing)Beijing102249China Department of Petroleum Engineering China University of Petroleum(Bejing)at KaramayKaramay83400oXinjiangChina CNPC Xinjiang Oilfield Company Karamay834000XinjiangChina

Tight reservoirs are typically developed by horizontal wells and multi-stage hydraulic *** conglomerate reservoir is one type of tight reservoirs,which is different from homogeneous rock,such as tight *** is because that the existence of gravels makes conglomerate have strong ***,it is difficult to grasp the fracture mechanism and the law of fracture propagation of conglomerate,which limits the efficient development of the conglomerate *** this paper,the fracture characteristics and factors influencing the fracturing of Mahu conglomerate were studied by uniaxial compression,acoustic emission monitoring and X-ray computed tomography(CT)scanning *** results show that the fracture characteristics of conglomerates are influenced by the gravel content and *** conglomerate in the study area is mainly divided into carbonate cemented conglomerate and clay cemented *** fracture complexity of carbonate cemented conglomerate first increases and then decreases with increasing gravel ***,for clay cemented conglomerates,the fracture complexity increases over the gravel *** crack development stress is a significant parameter in the crack assessment of *** study is useful to understand the influence of meso-fabric characteristics of conglomerates on their fracturing and crack evolution and guides the design of hydraulic fracturing.

关键词： Conglomerate Mechanical property Fracture characteristics Crack evolution

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Molecular Modeling Studies of 4-Hydroxyamino α-Pyranone Carboxamide Analogues as Hepatitis C Virus Inhibitor Using 3D-QSAR and Molecular Docking

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Chinese Journal of Structural Chemistry 2020年第6期39卷 1135-1145页

作者： tong jian-Bo WU Lu-Yang LEI Shan WANG Tian-Hao MA Yang-Min College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi'an 710021China Shaanxi Key Laboratory of Chemical Additives for Industry Xi'an 710021China

In this paper, 42 4-hydroxyamino α-pyranone carboxamide analogues as Hepatitis C Virus(HCV) inhibitor 3 D-QSAR model was built based on Topomer CoMFA. The non-cross-validation(r2), cross-validation(q2), correlation coefficient of external validation(Q ext2), non-cross validated standard error(SD), standard error of prediction(SDCV) and F are 0.909, 0.615, 0.967, 0.13, 0.28 and 37.287, respectively. The obtained Topomer CoMFA model has good estimation stability and prediction capability. Topomer Search was employed as a tool for virtual screening in lead-like compounds in the ZINC database. Then, 6 R1 groups and 4 R2 groups with higher contribution values were employed to alternately substitute for the R1 and R2 of the template compound 21 with the highest bioactivity. As a result, 22 new molecules with higher activity than that of the template molecule were designed successfully. The Topomer Search technology could be effectively applied to screen and design new 4-hydroxyamino α-pyranone carboxamide analogues. The molecular docking method was also used to study the interactions of these drugs by docking the ligands into HCV active site, which revealed the likely bioactive conformations. This study showed extensive interactions between the 4-hydroxyamino α-pyranone carboxamide analogues and the active sites of HCV(residues TYR466, GLN384, TYR383 and ASP335). The design of potent new inhibitors of HCV can get useful insights from these results.

关键词： 3D-QSAR 4-hydroxyamino a-pyranone carboxamide analogues topomer CoMFA molecule design molecular docking

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Mitochondria as extranuclear targets of ionizing radiation

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中华放射医学与防护杂志 2015年第1期35卷 3-7页

作者： tong jian tongjian 215123 Suzhou School of Public Health MedicalCollege of Soochow University

According to classical theory of radiation biology,the main target of ionizing radiation damage is believed to be the DNA in the cell ***,the discovery of so-called non-target effects,such as radiation-induced genomic instability in the progeny of cells survived from irradiation and bystander effects on cells not directly exposed to radiation,has challenged the central dogma of radiation biology in recent years[1-3].Previous studies have demonstrated that extranuclear target also plays an important role in mediating the genotoxicity of ionizing radiation[4],but the details of the cytoplasmic effects on genomic instability in hit cells is largely unexploited,mainly due to the technical difficulties in selectively targeting the cytoplasm without affecting the nucleus.

关键词：临床医学诊断放射医学

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基于环丁烯-1,2-二羧酸分子的二维有机铁电分子晶体单层的设计与理论研究

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物理学报 2022年第6期71卷 277-286页

作者：童健马亮东南大学物理学院南京211189

有机分子铁电材料相较于传统无机铁电材料具有轻质、柔性、不含重金属原子和成本低等诸多优点,长期以来得到了广泛的关注和研究.近年来,原子厚度的二维无机铁电材料的研究取得了突破性进展,因而备受关注,然而二维有机铁电材料的设计与... 详细信息

有机分子铁电材料相较于传统无机铁电材料具有轻质、柔性、不含重金属原子和成本低等诸多优点,长期以来得到了广泛的关注和研究.近年来,原子厚度的二维无机铁电材料的研究取得了突破性进展,因而备受关注,然而二维有机铁电材料的设计与研究却鲜有报道.本文基于密度泛函理论方法设计了一种以环丁烯-1,2-二羧酸(cyclobutene-1,2-dicarboxylic acid,CBDC)分子为结构单元的二维单层有机铁电分子晶体.由于CBDC分子晶体内部氢键的链状排布,导致其块体呈现出明显的层状结构,计算发现内部的氢键链使得CBDC分子晶体块体具有各向异性的剥离能,因此有望由沿着剥离能最低的(102)晶面进行机械/化学剥离而获得相应的单层有机铁电分子晶体.理论计算预测CBDC(102)分子晶体单层的面内自发极化约0.39×10^(-6)μC/cm,可与部分无机同类相比拟.计算表明CBDC(102)分子晶体单层具有较高的极化反转势垒,且对外加单轴应力的响应较为敏感.CBDC(102)单层有机铁电分子晶体的高面内自发极化以及易被界面调控的极化反转势垒使其可被应用于轻质无金属及柔性铁电器件.

关键词：二维分子晶体有机铁电面内极化极化反转

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lncRNA PVT1和微小RNA-106a-5p对骨肉瘤MG-63细胞的影响及机制研究

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哈尔滨医科大学学报 2024年第3期58卷 227-231页

作者：魏建仝张晓云邹永刚王勇平河西学院附属张掖人民医院骨科甘肃张掖734000 河西学院附属张掖人民医院病理科甘肃张掖734000 兰州大学第一医院骨科甘肃兰州730000

目的探讨长链非编码RNA(long non-coding RNA,lncRNA)PVT1和miR-106a-5p对骨肉瘤细胞恶性行为的影响及分子机制。方法将骨肉瘤MG-63细胞分为NC组、PVT1-siRNA组、miRNA抑制剂组以及共转染组。以CCK-8实验检测细胞增殖能力,以流式细胞仪... 详细信息

目的探讨长链非编码RNA(long non-coding RNA,lncRNA)PVT1和miR-106a-5p对骨肉瘤细胞恶性行为的影响及分子机制。方法将骨肉瘤MG-63细胞分为NC组、PVT1-siRNA组、miRNA抑制剂组以及共转染组。以CCK-8实验检测细胞增殖能力,以流式细胞仪检测细胞凋亡情况,以DCFH-DA法检测细胞活性氧(reactive oxygen species,ROS)水平,以实时荧光定量聚合酶链反应(real-time fluorescent quantitative polymerase chain reaction,RT-qPCR)检测基因表达,以蛋白印迹法检测谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4),铁蛋白(ferritin heavy chain,FTH)、血红素氧合酶1(heme oxygenase-1,HO1)和MDM4(murine double minute 4,MDM4)的表达水平。结果CCK-8实验结果显示敲低lncRNA PVT1后MG-63细胞12 h、24 h、48 h、72 h增殖能力降低(P<0.05),流式细胞仪检测结果显示敲低lncRNA PVT1后MG-63细胞凋亡水平以及ROS水平显著升高(P<0.05),lncRNA PVT1敲低联合miR-106a-5p抑制剂相对于lncRNA PVT1敲低组结果逆转(P<0.05)。RT-qPCR实验结果显示敲低lncRNA PVT1后miR-106a-5p基因表达水平升高并抑制MDM4基因表达(P<0.05),Western blot结果显示敲低lncRNA PVT1后抑制MDM4、HO1、GPX4和FTH蛋白水平(P<0.05)。结论在人骨肉瘤MG-63中,抑制lncRNA PVT1表达可促进miR-106a-5p表达,促进铁死亡和凋亡并抑制增殖。

关键词：骨肉瘤 lncRNA PVT1 miR-106a-5p 铁死亡增殖凋亡

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BACE1 in the retina:a sensitive biomarker for monitoring early pathological changes in Alzheimer's disease

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Neural Regeneration Research 2016年第3期11卷 447-453页

作者： Lan Li Jia Luo Dan Chen jian-bin tong Le-ping Zeng Yan-qun Cao jian Xiang Xue-gang Luo Jing-ming Shi Hui Wang Ju-fang Huang Department of Anatomy and Neurobiology School of Basic Medical SciencesCentral South University Department of Anesthesiology Third Xiangya Hospital of Central South University Department of Ophthalmology Second Xiangya HospitalCentral South University

Because of a lack of sensitive biomarkers,the diagnosis of Alzheimer＇s disease（AD） cannot be made prior to symptom ***,it is crucial to identify novel biomarkers for the presymptomatic diagnosis of *** brain lesions are a major feature of AD,retinal pathological changes also occur in *** this study,we investigated the temporal changes in β-site APP-cleaving enzyme 1（BACE1） expression in the retina and brain to determine whether it could serve as a suitable biomarker for early monitoring of ***/PS-1 transgenic mice,3,6 and 8 months of age,were used as an experimental group,and age-matched C57/BL6 wild-type mice served as the control *** the Morris water maze test,there were no significant differences in escape latency or in the number of crossings in the target area among mice of different *** with wild-type mice,no changes in learning or memory abilities were detected in transgenic mice at 3 months of ***,compared with wild-type mice,the escape latency was significantly increased in transgenic mice at 6 months,starting on day 3,and at 8 months,starting on day 2,during Morris water maze *** addition,the number of crossings of the target area was significantly decreased in transgenic *** learning and memory abilities of transgenic mice were further worsened at 8 months of *** staining revealed no BACE1 plaques in wild-type mice at 3,6 or 8 months or in transgenic mice at 3 months,but they were clearly found in the entorhinal cortex,hippocampus and prefrontal cortex of transgenic mice at 6 and 8 ***1 expression was not detected in the retina of wild-type mice at 3 months,but weak BACE1 expression was detected in the ganglion cell layer,inner plexiform layer and outer plexiform layer at 6 and 8 *** transgenic mice,BACE1 expression in the ganglion cell layer was increased at 3 months,and BACE1 expression in the ganglion cell layer,inner plexiform layer and outer plex

关键词： nerve regeneration neurodegenerative disease Alzheimer's disease retina amyloid-β β-site amyloid precursor protein cleaving enzyme 1 APP/PS-1 transgenic mouse neural regeneration

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