Mitochondria as extranuclear targets of ionizing radiation

作     者：Tong Jian TongJian Tong Jian

作者机构：215123 Suzhou School of Public Health MedicalCollege of Soochow University 

出 版 物：《中华放射医学与防护杂志》 (Chinese Journal of Radiological Medicine and Protection)

年 卷 期：2015年第35卷第1期

页      面：3-7页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by grants from Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) the Jiangsu Key Lab of Preventive and Translational Medicine for Geriatric Diseases 

主　　题：临床 医学 诊断 放射医学 

摘      要：According to classical theory of radiation biology,the main target of ionizing radiation damage is believed to be the DNA in the cell ***,the discovery of so-called non-target effects,such as radiation-induced genomic instability in the progeny of cells survived from irradiation and bystander effects on cells not directly exposed to radiation,has challenged the central dogma of radiation biology in recent years[1-3].Previous studies have demonstrated that extranuclear target also plays an important role in mediating the genotoxicity of ionizing radiation[4],but the details of the cytoplasmic effects on genomic instability in hit cells is largely unexploited,mainly due to the technical difficulties in selectively targeting the cytoplasm without affecting the nucleus.