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Tauroursodeoxycholic acid:more than just a neuroprotective bile conjugate

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Neural Regeneration Research 2017年第1期12卷 62-63页

作者： Lorenzo romero-Ramírez manuel Nieto-sampedro Natalia Yanguas-Casás Hospital Nacional de Paraplejicos SESCAMToledoSpain Instituto Cajal CSICMadridSpain

Neurological diseases and the neuroinflammatory response：Neurological diseases are usually accompanied by dramatic changes in the tissue homeostasis,inducing a neuroinflammatory environment that leads to the progress... 详细信息

关键词： Tauroursodeoxycholic acid more than just a neuroprotective bile conjugate TGF CNs

Hepatitis C virus genotype 3: Meta-analysis on sustained virologic response rates with currently available treatment options

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World Journal of Gastroenterology 2016年第22期22卷 5285-5292页

作者： Javier Ampuero K Rajender Reddy manuel romero-Gomez Inter-Centre Unit of Digestive Diseases and CIBERehd Virgen Macarena Virgen del Rocio University Hospitals University of Sevilla 41018 Sevilla Spain Instituto de Biomedicina de sevilla 41018 Sevilla Spain Division of Gastroenterology and Hepatology Department of Medicine University of Pennsylvania Philadelphia PA 19107 United States

AIM: To address the therapeutic efficacy of various treatment regimens in genotype 3 selecting randomized clinical trials and prospective National Cohort ***:(1) PEG-INF-based therapy including sofosbuvir(sOF) + RBV for 12 wk vs sOF + RBV 24 wk;(2) sOF + RBV therapy 12 wk/16 wk vs 24 wk; and(3) the role of RBV in sOF + daclatasvir(DCV) and sOF + ledipasvir(LDV) combinations. This metaanalysis provides robust information with the intention of addressing treatment strategy for hepatitis C virus genotype ***: A combination treatment including sOF + RBV + PEG-IFN for 12 wk notes better sVR than with only sOF + RBV for 12 wk, although its association with more frequent adverse effects may be a limiting factor. Longer duration therapy with sOF + RBV(24 wk) has achieved higher sVR rates than shorter durations(12 or 16 wk). sOF + LDV are not an ideal treatment for genotype 3. CONCLUsION: Lastly, sOF + DCV combination is probably the best oral therapy option and the addition of RBV does not appear to be needed to increase sVR rates substantially.

关键词： Hepatitis C Genotype 3 sofosbuvir Daclatasvir Ledipasvir

On Lagrange-Projection schemes for shallow Water Flows Over Movable Bottom with suspended and Bedload Transport

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Numerical Mathematics(Theory,Methods and Applications) 2023年第4期16卷 1087-1126页

作者： Alessia Del Grosso manuel J.castro Díaz Christophe Chalons Tomás Morales de Luna UniversitéParis-saclay UVSQCNRSLaboratoire de Mathématiques de Versailles78000VersaillesFrance Dpto.de Análisis Matemático Facultad de CienciasUniversidad de MálagaCampus de Teatinos S/N29081 MálagaSpain

In the present work we aim to simulate shallow water flows over movable bottom with suspended and bedload *** order to numerically approximate such a system,we proceed step by *** start by considering shallow water equations with non-constant density of the mixture ***,the Exner equation is included to take into account bedload sediment ***,source terms for friction,erosion and deposition processes are ***,observe that the sediment particle could go in suspension into the water or being deposited on the *** the numerical scheme,we rely on well-balanced Lagrange-projection *** particular,since sediment transport is generally a slow process,we aim to develop semi-implicit schemes in order to obtain fast *** Lagrange-projection splitting is well-suited for such a purpose as it entails a decomposition of the(fast)acoustic waves and the(slow)material waves of the ***,in subsonic regimes,an implicit approximation of the acoustic equations allows us to neglect the corresponding CFL condition and to obtain fast numerical schemes with large time step.

关键词： shallow water flows movable bottom erosion-deposition processes Lagrangeprojection schemes implicit-explicit schemes

Entry of hepatitis C virus into the cell: A therapeutic target

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World Journal of Gastroenterology 2012年第33期18卷 4481-4485页

作者： José Antonio Del Campo ngela Rojas manuel romero-Gómez Unit for Medical and surgical Management of Digestive Diseases Center for Biomedical Research in Digestive and Liver Diseases Network (CIBERehd) Valme University Hospital University of Seville E-41014 Sevilla Spain

several receptors have been identified as implicated on viral entry into the hepatocyte; and, this interaction between the virus and potential receptors could modulate infection, spontaneous viral clearance, persistence of the infection and the widespread of the virus as outbreak. Nevertheless, the playing role of each of them remains controversial. The NiemannPick type C1 like 1 gene (NPC1L1) receptor has been recently implicated on hepatitis C virus (HCV) entry into the cell and ezetimibe, an anti-cholesterol drug seems to block that, emerging the idea to control hepatitis C outbreak modulating lipid-related receptors. Hepatitis C infection seems to modulate lipid metabolism according to host genetic background. Indeed, it circulates like a lipoviroparticle. The main aim of this field of vision would be to discuss the role of hepatocyte receptors implicated on virus entry, especially NPC1L1 and the therapeutic options derived from the better knowledge about HCV-lipidsreceptors interaction.

关键词： Hepatitis C virus entry Niemann-Pick type C1 like 1 gene Lipid metabolism Ezetimibe

Near shore seismic movements induced by seaquakes using the boundary element method

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Earthquake Engineering and Engineering Vibration 2017年第3期16卷 571-585页

作者： Alejandro Rodríguez-Castellanos manuel Carbajal-romero Norberto Flores-Guzmán J.Efraín Rodríguez-sánchez Andriy Kryvko instituto mexicano del petróleo eje central lázaro cárdenas 152Gustavo A.MaderoDistrito FederalMéxico escuela superior de ingeniería mecánicay eléctrica instituto politécnico nacionalupalmEdif.5Av.Instituto Politécnico Nacional S/NCol.LindavistaGustavo A.MaderoDistrito FederalMéxico escuela superior de ingeniería mecánicay eléctrica instituto politécnico nacionalunidad profesional azcapotzalcoDistrito FederalMéxico centro de investigación en matemáticas jalisco s/nmineral de valencianaguanajuatoMéxico

This study quantifies seismic amplifications in near-shore arising from seaquakes. Within the Boundary Element Method, boundary elements are used to irradiate waves and force densities obtained for each element. Huygens′ Principle is implemented since the diffracted waves are constructed at the boundary from which they are radiated, which is equivalent to somigliana′s theorem. Application of boundary conditions leads to a system of integral equations of the Fredholm type of second kind and zero order. several numerical configurations are analyzed： The first is used to verify the present formulation with ideal sea floor configurations to estimate seismic amplifications. With the formulation verified, simple slope configurations are studied to estimate spectra of seismic motions. It is found that P-waves can produce seismic amplifications from 1.2 to 3.9 times the amplitude of the incident wave. sV-waves can generate seismic amplifications up to 4.5 times the incident wave. Another relevant finding is that the highest amplifications are at the shore compared to the ones at the sea floor.

关键词： seismic amplifications seaquake earthquake elastic waves boundary element method near shore cities

High-pressure scheelite-type polymorph of smCrO_4: synthesis, structural characterization and magnetic properties

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Journal of Rare Earths 2010年第6期28卷 936-939页

作者： Regino sáez-Puche Mahmoud Gamal Rabie Julio romero de Paz José-manuel Gallardo-Amores Esteban Climent Pascual Department of Inorganic Chemistry Faculty of Chemical Sciences Complutense University of Madrid Ciudad Universitaria

The new scheelite form of smCrO4 oxide was obtained by heating the zircon-type smCrO4 oxide at 4 GPa and 803 K. X-ray diffraction revealed that this scheelite smCrO4 phase crystallized with tetragonal symmetry, s.G. I41/a and lattice parameters: a=0.50776(3) nm and c=1.15606(2) nm. This structural phase transition from zircon to scheelite involved a decreasing of around 10% in the unit cell volume. Although the Cr-O and sm-O distances did not change very much in both zircon and scheelite polymorphs, the changes occurred in the bond angles were remarkable that appear to support the proposed reconstructive model to explain this structural zircon-scheelite phase transition. Magnetic susceptibility and magnetization measurements revealed that the scheelite smCrO4 oxide behaved an antiferromagnetic material, where the sm3+ and Cr5+ were simultaneously ordered. The estimated Néel temperature, TN, was 16 K and the critical field at 12 K associated with the metamagnetic transition was 3.2 T.

关键词： scheelite-type structure zircon-type structure high pressure synthesis antiferromagnetic behaviour metamagnetic transition rare earths

solving Two-Mode shallow Water Equations Using Finite Volume Methods

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Communications in Computational Physics 2014年第10期16卷 1323-1354页

作者： manuel jesus castro Dıaz Yuanzhen Cheng Alina Chertock Alexander Kurganov Dpto.de Analisis Matematico Facultad de CienciasUniversidad de MalagaCampus de Teatinos29071 M´alagaSpain. Mathematics Department Tulane UniversityNew OrleansLA 70118USA. Department of Mathematics North Carolina State UniversityRaleighNC 27695USA.

In this paper,we develop and study numerical methods for the two-mode shallow water equations recently proposed in[***,***,and ***,*** Dynamics,22(2008),pp.407–432].Designing a reliable numerical method for this system is a challenging task due to its conditional hyperbolicity and the presence of nonconservative *** present several numerical approaches—two operator splitting methods(based on either Roe-type upwind or central-upwind scheme),a central-upwind scheme and a path-conservative centralupwind scheme—and test their performance in a number of numerical *** obtained results demonstrate that a careful numerical treatment of nonconservative terms is crucial for designing a robust and highly accurate numerical method。

关键词： Two-mode shallow water equations nonconservative products conditional hyperbolicity finite volume methods central-upwind schemes splitting methods upwind schemes.

Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury:focus on the visual system

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Neural Regeneration Research 2021年第11期16卷 2125-2131页

作者： Fernando Lucas-Ruiz Caridad Galindo-romero Virginia Albaladejo-García manuel Vidal-sanz Marta Agudo-Barriuso Departamento de Oftalmología Facultad de MedicinaUniversidad de Murcia and Instituto Murciano de Investigación Biosanitaria-Virgen de la Arrixaca(IMIBArrixaca)MurciaSpain

The retina,as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new *** the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in the contralateral uninjured *** effect has been better studied in the visual system where,as a rule,one retina is used as experimental and the other as *** retinas in unilateral models of retinal injury show neuronal degeneration and glial *** mechanisms by which this adverse response in the central nervous system occurs are discussed in this review,focusing primarily on the visual system.

关键词： bilateral effect brain glaucoma inflammation mirror effect optic nerve axotomy optic nerve crush retina spinal cord

Perioperative management and early complications after intestinal resection with ileocolonic anastomosis in Crohn’s disease:analysis from the PRACTICROHN study

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Gastroenterology Report 2019年第3期7卷 168-175,I0001,I0002页

作者： Ana Gutierrez Montserrat Rivero Maria Dolores Martin-Arranz Valle Garcia sanchez manuel castro jesus Barrio Ruth de Francisco manuel Barreiro-de Acosta Berta Julia Luis Cea-Calvo Cristina romero Natalia Borruel sainz Eugeni Domenech Gastroenterology Department General University Hospital of Alicante and Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas(CIBERehd)CarlosⅢHealth InstituteMadridSpain Gastroenterology Department Marques de Valdecilla General University HospitalSantanderSpain Gastroenterology Department La Paz General University HospitalInstituto de Investigacion Biomedica La Paz(IdiPaz)MadridSpain Clinical Management of Gastrointestinal Tract Diseases Unit Reina Sofia University HospitalMaimonides Institute of Biomedical Research of Cordoba(IMIBIC)Cordoba UniversityCordobaSpain Gastroenterology Department Valme University HospitalSevillaSpain Gastroenterology Department University HospitalRio HortegaValladolidSpain Gastroenterology Department University Hospital Central de AsturiasOviedoSpain Gastroenterology Department Inflammatory Bowel Disease UnitUniversity Hospital Complex of Santiago de CompostelaSantiago de CompostelaSpain Medical Department Merck Sharp and DohmeMadridSpain Crohn-Colitis Care Unit(UACC) Digestive Tract ServiceHospital Universitari Vall d’HebronBarcelonaSpain Gastroenterology Department Germans Trias i Pujol University Hospital and CIBERehdBadalonaSpain

Background:This study is aimed at describing the prevalence of and risk factors associated with early post-operative complications after Crohn’s disease-related intestinal ***:This was a retrospective analysis of data from the PRACTICROHN *** Crohn’s disease patients who underwent ileocolonic resection with ileocolonic anastomosis between January 2007 and December 2010 were *** complications evaluated included death,ileus,anastomotic leak,abscess,wound infection,catheter-related infection,digestive bleeding and other extra-abdominal infections that occurred in the 30 days after ***:A total of 364 patients(median age at surgery 38 years and 50%men)were *** for surgery was:stricturing disease(46.4%),penetrating disease(31.3%),penetrating and stricturing disease(14.0%)or resistance to medical treatment(5.8%).Early complications were recorded in 100(27.5%)patients,with wound infection,intra-abdominal abscess and anastomotic leakage being the most frequent *** hospitalization duration was 16 days for patients with complications vs.9 days without complications(Ps were more common among patients with penetrating disease(36/114,31.6%)and those refractory to treatment(9/21,42.9%)compared with stricturing disease(45/169,26.6%)or stricturingtpenetrating disease(6/51,11.8%)(P=0.040).The rate of complications was higher among patients with diagnosis made at the time of surgery(15/31,48.4%)compared with the rest(85/331,25.7%)(P=0.013).Medication received at the time of surgery did not affect the rate of ***:Almost a quarter of patients developed early complications after intestinal *** disease and urgent surgery were associated with an increased risk of complications.

关键词： Ileocolonic resection Crohn’s disease post-operative complications risk factors