Perioperative management and early complications after intestinal resection with ileocolonic anastomosis in Crohn’s disease:analysis from the PRACTICROHN study

作     者：Ana Gutierrez Montserrat Rivero Maria Dolores Martin-Arranz Valle Garcia Sanchez Manuel Castro Jesus Barrio Ruth de Francisco Manuel Barreiro-de Acosta Berta Julia Luis Cea-Calvo Cristina Romero Natalia Borruel Sainz Eugeni Domenech 

作者机构：Gastroenterology DepartmentGeneral University Hospital of Alicante and Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas(CIBERehd)CarlosⅢHealth InstituteMadridSpain Gastroenterology DepartmentMarques de Valdecilla General University HospitalSantanderSpain Gastroenterology DepartmentLa Paz General University HospitalInstituto de Investigacion Biomedica La Paz(IdiPaz)MadridSpain Clinical Management of Gastrointestinal Tract Diseases UnitReina Sofia University HospitalMaimonides Institute of Biomedical Research of Cordoba(IMIBIC)Cordoba UniversityCordobaSpain Gastroenterology DepartmentValme University HospitalSevillaSpain Gastroenterology DepartmentUniversity HospitalRio HortegaValladolidSpain Gastroenterology DepartmentUniversity Hospital Central de AsturiasOviedoSpain Gastroenterology DepartmentInflammatory Bowel Disease UnitUniversity Hospital Complex of Santiago de CompostelaSantiago de CompostelaSpain Medical DepartmentMerck Sharp and DohmeMadridSpain Crohn-Colitis Care Unit(UACC)Digestive Tract ServiceHospital Universitari Vall d’HebronBarcelonaSpain Gastroenterology DepartmentGermans Trias i Pujol University Hospital and CIBERehdBadalonaSpain 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2019年第7卷第3期

页      面：168-175,I0001,I0002页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Merck Sharp and Dohme Spain 

主　　题：Ileocolonic resection Crohn’s disease post-operative complications risk factors 

摘      要：Background:This study is aimed at describing the prevalence of and risk factors associated with early post-operative complications after Crohn’s disease-related intestinal ***:This was a retrospective analysis of data from the PRACTICROHN *** Crohn’s disease patients who underwent ileocolonic resection with ileocolonic anastomosis between January 2007 and December 2010 were *** complications evaluated included death,ileus,anastomotic leak,abscess,wound infection,catheter-related infection,digestive bleeding and other extra-abdominal infections that occurred in the 30 days after ***:A total of 364 patients(median age at surgery 38 years and 50%men)were *** for surgery was:stricturing disease(46.4%),penetrating disease(31.3%),penetrating and stricturing disease(14.0%)or resistance to medical treatment(5.8%).Early complications were recorded in 100(27.5%)patients,with wound infection,intra-abdominal abscess and anastomotic leakage being the most frequent *** hospitalization duration was 16 days for patients with complications vs.9 days without complications(P0.001).Complications were more common among patients with penetrating disease(36/114,31.6%)and those refractory to treatment(9/21,42.9%)compared with stricturing disease(45/169,26.6%)or stricturingtpenetrating disease(6/51,11.8%)(P=0.040).The rate of complications was higher among patients with diagnosis made at the time of surgery(15/31,48.4%)compared with the rest(85/331,25.7%)(P=0.013).Medication received at the time of surgery did not affect the rate of ***:Almost a quarter of patients developed early complications after intestinal *** disease and urgent surgery were associated with an increased risk of complications.