Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury:focus on the visual system

作     者：Fernando Lucas-Ruiz Caridad Galindo-Romero Virginia Albaladejo-García Manuel Vidal-Sanz Marta Agudo-Barriuso Fernando Lucas-Ruiz;Caridad Galindo-Romero;Virginia Albaladejo-García;Manuel Vidal-Sanz;Marta Agudo-Barriuso

作者机构：Departamento de OftalmologíaFacultad de MedicinaUniversidad de Murcia and Instituto Murciano de Investigación Biosanitaria-Virgen de la Arrixaca(IMIBArrixaca)MurciaSpain 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第11期

页      面：2125-2131页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：supported by the Spanish Ministry of Economy and Competitiveness,Instituto de Salud Carlos III,Fondo Europeo de Desarrollo Regional“Una manera de hacer Europa”(PI19/00071[to MAB],PID2019-106498GB-I00[to MVS],RD16/0008/0026[to MVS]and RD16/0008/0016[to MVS]) the Fundación Séneca,Agencia de Ciencia y Tecnología Región de Murcia(19881/GERM/15)(to MVS) 

主　　题：bilateral effect brain glaucoma inflammation mirror effect optic nerve axotomy optic nerve crush retina spinal cord 

摘      要：The retina,as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new *** the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in the contralateral uninjured *** effect has been better studied in the visual system where,as a rule,one retina is used as experimental and the other as *** retinas in unilateral models of retinal injury show neuronal degeneration and glial *** mechanisms by which this adverse response in the central nervous system occurs are discussed in this review,focusing primarily on the visual system.