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SHP gains citizenship of the AMPK kingdom

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Cellular & Molecular Immunology 2011年第6期8卷 450-452页

作者： hun-taeg chung School of Biological Sciences University of UlsanMetaInflammation Basic Research LaboratoryUlsanKorea

Various cytokines and chemokines are produced as a result of signaling through innate immune *** signaling is initiated by host–pathogen interactions in which the host’s germline-encoded pattern recognition receptors,including Toll-like receptors(TLRs),recognize conserved microbial structures termed pathogen-associated molecular *** are broadly distributed in immune cells and are responsible for eliciting innate responses and enhancing adaptive immunity to *** 12 members of the TLR family in mammals are characterized by an extracelluar leucine-rich repeat domain and an intracellular Toll/IL-1 receptor domain.

关键词： immunity cytokines initiated

Metabolic signaling functions of the heme oxygenase/CO system in metabolic diseases

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Cellular & Molecular Immunology 2018年第12期15卷 1085-1087页

作者： Hyo Jeong Kim Yeonsoo Joe Young-Joon Surh hun taeg chung Department of Biological Sciences University of UlsanUlsanSouth Korea Tumor Microenvironment Global Core Research Center Research Institute of Pharmaceutical SciencesSeoul National UniversitySeoulSouth Korea

Immunometabolism is the intersection of immunology and *** heme oxygenase(HO)-1 and carbon monoxide(CO)(HO-1/CO)system can be induced by various stresses,including infection,and its function is to relieve stresses such as oxidative and inflammatory *** we demonstrate that the HO-1/CO system is intimately involved in the beneficial modulation of metabolic pathways via the production of ATF4 through an integrative stress response.

关键词： system monoxide oxidative

IRG1 induced by heme oxygenase- 1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production

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Cellular & Molecular Immunology 2016年第2期13卷 170-179页

作者： Md Jamal Uddin Yeonsoo Joe Seul-Ki Kim Sun Oh Jeong Stefan W Ryter Hyun-Ock Pae hun taeg chung School of Biological Sciences University of Ulsan Korea Department of Microbiology and Immunology Wonkwang University School of Medicine Korea Joan and Sanford I. Weill Department of Medicine New York-Presbyterian Hospital Weill Cornell Medical College New York USA

The immunoresponsive gene 1 （IRG 1） protein has crucial functions in embryonic implantation and neurodegeneration. IRG1 promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species （ROS）. The cytoprotective protein heme oxygenase-1 （HO-1）, which generates endogenous carbon monoxide （CO）, is expressed in the lung during Lipopolysaccharide （LPS） tolerance and cross tolerance. However, the detailed molecular mechanisms and functional links between IRG1 and HO-1 in the innate immune system remain unknown. In the present study, we found that the CO releasing molecule-2 （CORM-2） and chemical inducers of HO- 1 increased I RG 1 expression in a time- and dose-dependent fashion in RAW264.7 cells. Furthermore, inhibition of HO-1 activity by zinc protoporphyrin IX （ZnPP） and HO-1 siRNA significantly reduced expression of IRG1 under these conditions. In addition, treatment with CO and HO-1 induction significantly increased A20 expression, which was reversed by ZnPP and HO-1 siRNA. LPS-stimulated TNF-a was significantly decreased, whereas IRG1 and A20 were increased by CORM-2 application and HO-1 induction, which in turn were abrogated by ZnPP. Interestingly, siRNA against IRG1 and A20 reversed the effects of CO and HO-1 on LPS-stimulated TNF-a production. Additionally, CO and HO-1 inducers significantly increased IRG1 and A20 expression and downregulated TNF-a production in a LPS-stimulated sepsis mice model. Furthermore, the effects of CO and HO-1 on TNF-α production were significantly reversed when ZnPP was administered. In conclusion, CO and HO-1 induction regulates IRG1 and A20 expression, leading to inhibition of inflammation in vitroand in an in vivomice model.

关键词： A2O anti-inflammatory effects carbon monoxide HO-1 IRG1

Carbon monoxide decreases interleukin-1β levels in the lung through the induction of pyrin

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Cellular & Molecular Immunology 2017年第4期14卷 349-359页

作者： Seul-Ki Kim Yeonsoo Joe Yingqing Chen Jinhyun Ryu Jeong-Hee Lee Gyeong Jae Cho Stefan W. Ryter hun taeg chung Department of Biological Sciences University of Ulsan Ulsan 680-749 Republic of Korea Department of Anatomy School of Medicine and Institute of Health Sciences Gyeongsang National University Jinju 660-701 Republic of Korea Department of Pathology School of Medicine and Institute of Health Sciences Gyeongsang National University Jinju 660-701 Republic of Korea Joan and Sanford I. Weill Department of Medicine New York-Presbyterian Hospital Division of Pulmonary and Critical Care Medicine Weill Cornell Medical Center New York NY USA

Carbon monoxide （CO） can act as an anti-inflammatory effector in mouse models of lung injury and disease, through the downregulation of pro-inflammatory cytokines production, though the underlying mechanisms remain unclear. The nucleotide-binding oligomerization domain-, leucine-rich region-, and pyrin domain-containing-3 （NLRP3） inflammasome is a protein complex that regulates the maturation and secretion of pro-inflammatory cytokines, including interleukin-1β （IL-1β）. In this report, we show that the CO-releasing molecule （CORM-2） can stimulate the expression of pyrin, a negative regulator of the NLRP3 inflammasome. CORM-2 increased the transcription of pyrin in the human leukemic cell line （THP-1） in the absence and presence of lipopolysaccharide （LPS）. In THP-1 cells, CORM-2 treatment dose-dependently reduced the activation of caspase-1 and the secretion of IL-lp, and increased the levels of IL-IO, in response to LPS and adenosine 5＇-triphosphate （ATP）, an NLRP3 inflammasome activation model. Genetic interference of IL-10 by small interfering RNA （siRNA） reduced the effectiveness of CORM-2 in inhibiting IL-1β production and in inducing pyrin expression. Genetic interference of pyrin by siRNA increased IL-lp production in response to LPS and ATP, and reversed CORM-2-dependent inhibition of caspase-1 activation. CO inhalation （250 ppm） in vivo increased the expression of pyrin and IL-10 in lung and spleen, and decreased the levels of IL-1β induced by LPS. Consistent with the induction of pyrin and IL-10, and the downregulation of lung IL-1β production, CO provided protection in a model of acute lung injury induced by intranasal LPS administration. These results provide a novel mechanism underlying the anti-inflammatory effects of CO, involving the IL-10-dependent upregulation of pyrin expression.

关键词： anti-inflammatory effects carbon monoxide (CO) IL-1β inflammasome pyrin

1,2,3,4,6-penta-O-galloyl-β-D-glucose up-regulates heme oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular signal-regulated kinase-dependent manner in HepG2 cells

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World Journal of Gastroenterology 2006年第2期12卷 214-221页

作者： Hyun-Ock Pae Gi-Su Oh Sun-On Jeong Gil-Saeng Jeong Bok-Soo Lee Byung-Min Choi Ho-Sub Lee hun-taeg chung Medicinal Resources Research Institute Wonkwang UniversityIksan-ShiChunbug570-749Republic of Korea Department of Microbiology and Immunology Wonkwang University School of MedicineWonkwang UniversityIksan-ShiChunbug570-749Republic of Korea

AIM: To examine the potency of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) as a hepatic heme oxygen-ase-1(HO-1) inducer and its regulation in HepG2 cells. METHODS: Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAP) kinases were analyzed by Western blot, immuno-fluorescence assay, and flow cytometry. Transfections of HO-1 gene, small interfering RNAs for HO-1 and Nrf2, and dominant-negative gene for MAP/extracellular signal-regulated kinase (ERK) were carried out to dissect the signaling pathways leading to HO-1 expression in HepG 2 cells. RESULTS: PGG up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-butyl hydroperoxide. Moreover, PGG induced Nrf2 nuclear translocation, which was found to be an upstream step of PGG-induced HO-1 expression, and ERK activation, of which pathway was involved in PGG-induced Nrf2 nuclear translocation, HO-1 expression and cytoprotection. CONCLUSION: PGG up-regulates HO-1 expression by stimulating Nrf2 nuclear translocation in an ERK-depen-dent manner, and HO-1 expression by PGG may serve as one of the important mechanisms for its hepatoprotective effects.

关键词：胃癌三羟苯甲酰葡萄糖血红素加氧酶氧化压力

Combined Insights from Leachate Structure and Microstructure Characteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies

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Rice science 2024年第4期31卷 475-488,I0035,I0036页

作者： Mingyo HA Hyo-Young JEONG Ju hun LEE Hyun-Jung chung Division of Food and Nutrition Chonnam National UniversityGwangju 61186South Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul 02841South Korea Division of Food Science&Culinary Arts Shinhan UniversityGyeonggi 11644South Korea

Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample had the highest total solids and amylopectin amount in the leachate. The amylopectin amount in the leachate differed significantly based on the targeted water content. Morphological characterization revealed that the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural hardness of the AEC_58% sample was much higher than that of the other samples. The PSC_63% sample had the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leachate. Sensory characterization showed that the PSC_63% sample had the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leachate and textural and sensory characteristics of reheated convenience rice among the different processing technologies.

关键词： reheated convenience rice starch structure leachate multi-scale structure eating quality processing technology

Cryptanalysis of the obfuscated round boundary technique for whitebox cryptography

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Science China(Information Sciences) 2020年第3期63卷 257-265页

作者： Yongjin YEOM Dong-Chan KIM chung hun BAEK Junbum SHIN Department of Information Security Cryptology and Mathematics Kookmin University Samsung Research Samsung Electronics

Dear editor,The security of cryptographic techniques heavily relies on the confidentiality of the key, and everything except keys can be made open to public without affecting security. When working with cryptographic services, we must protect the keys from a variety of attackers, including eavesdroppers and malware. A whitebox adversary is an attacker

关键词： II Cryptanalysis of the obfuscated round boundary technique for whitebox cryptography

Direct ink writing of polycaprolactone/polyethylene oxide based 3D constructs

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Progress in Natural Science:Materials International 2021年第2期31卷 180-191页

作者： Bin Zhang Se hun chung Susan Barker Duncan Craig Roger J.Narayan Jie Huang Department of Mechanical Engineering University College London Medway School of Pharmacy Universities of Greenwich and Kent School of Pharmacy University College London Joint Department of Biomedical Engineering University of North Carolina and North Carolina State University

There has been increasing interest over recent years in the application of three-dimensional(3 D) printing technologies in the biomedical field. One such method is Direct Ink Writing(DIW); this approach has the potential advantage of allowing room-temperature deposition of materials, presented as an ink, to build complex architectures. DIW offers the ability to process biomaterials containing temperature-sensitive components. Due to the fabrication principles of DIW, there are specific rheological requirements that the ink must exhibit for the 3 D construction. For this reason, hydrogel-based liquid feed stocks have been the focal point of ink development. As a consequence, studies based on inks comprising hydrophobic biomaterials, which are insoluble in water and hence unsuited to the hydrogel approach, have been *** this study, we investigate novel inks that utilize polycaprolactone(PCL), a hydrophobic polymer, as the primary constituent by dissolving the polymer in solvent systems based on dichloromethane(DCM) and acetone(ACE). Moreover, polyethylene oxide(PEO) was incorporated into the PCL systems in order to extend the range of hydrophilicity of the systems. The rheological properties of the inks were investigated as a function of polymer composition and solvent system. Woodpile constructs of PCL and PCL/PEO were fabricated using DIW method and were assessed by a series of material characterisation. The type of solvent system had a noticeable impact on the ink rheology, which ultimately affected the surface properties. The incorporation of PEO particularly enhanced the roughness and wettability of the constructs. Our results support the use of DIW as a new means to process hydrophobic polymers for biomedical applications.

关键词： Direct ink writing Polycaprolactone Polyethylene oxide Ink rheology Material characterisation 3D construct

Exercise intervention under hypoxic condition as a new therapeutic paradigm for type 2 diabetes mellitus:A narrative review

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World Journal of Diabetes 2021年第4期12卷 331-343页

作者： Sung-Woo Kim Won-Sang Jung Sochung chung hun-Young Park Physical Activity and Performance Institute(PAPI) Konkuk UniversitySeoul 05029South Korea Department of Pediatrics Konkuk University Medical CenterResearch Institute of Medical ScienceKonkuk UniversitySchool of MedicineSeoul 05029South Korea Department of Sports Science and Medicine Konkuk UniversitySeoul 05029South Korea

This review aims to summarize the health benefits of exposure to hypoxic conditions during exercise in patients with type 2 diabetes mellitus(T2 DM).Exposure to hypoxic conditions during exercise training positively changes the physiological response in healthy *** to hypoxic conditions during exercise could markedly increase skeletal muscle glucose uptake compared to that in normoxic ***,post-exercise insulin sensitivity of T2 DM patients increases more when exercising under hypoxic than under normoxic *** exercise under short-term hypoxic conditions can improve blood glucose control at lower workloads than in normoxic ***,exercise training under short-term hypoxic conditions can maximize weight loss in overweight and obese *** studies on healthy subjects have reported that regular exercise under hypoxic conditions had a more positive effect on vascular health than exercising under normoxic ***,currently,evidence indicating that exposure to hypoxic conditions could positively affect T2 DM patients in the long-term is ***,further evaluations of the beneficial effects of exercise under hypoxic conditions on the human body,considering different cycle lengths,duration of exposures,sessions per day,and the number of days,are *** this review,we conclude that there is evidence that exercise under hypoxic conditions can yield health benefits,which is potentially valuable in terms of clinical care as a new intervention for T2 DM patients.

关键词： Exercise Hypoxia Insulin-resistance Metabolism Type 2 diabetes mellitus Weight loss