RIP140, a Janus metabolic switch involved in defense functions

作     者：Hun Taeg Chung 

作者机构：School of Biological Sciences University of Ulsan Meta-Inflammation Basic Research Laboratory Ulsan KoreaCorrespondence: Dr HT Chung School of BiologicalSciences University of Ulsan Meta-lnflammation BasicResearch Laboratory Ulsan Korea. 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2013年第10卷第1期

页      面：7-9页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 081704[工学-应用化学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0903[农学-农业资源与环境] 0713[理学-生态学] 

主　　题：RIP140 Janus metabolic switch defense functions 

摘      要：Since its discovery almost 15 years ago, the receptor-interacting protein RIP140has been determined to be a corepressor of various transcription factors and nuclear receptors. Mice lacking the RIP140 gene are lean, exhibit resistance to high-fat diet- induced obesity and have increased glucose tolerance and insulin sensitivity. In 2008, RIP140 was determined to be a coactivator of nuclear factor-~cB, a master transcriptional regulator of inflammation in immune cells, including macrophages. This year, it was reported that RIP 140 degradation is involved in the resolution of inflammation and in endotoxin tolerance. The general picture that had emerged indicates that RIP140 is a ]anus metabolic switch that convergently regulates metabolic pathways involved in defense func- tions through its pleotropic interactions with transcription factors.