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High Temperature Creep and Fracture Behavior of a Directionally Solidified Ni-base Superalloy

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Journal of Materials Science & Technology 1998年第3期14卷 219-225页

作者： Yuan, Chao Guo, Jianting Wang, Shuhe yang, hongcai Acad Sinica Inst Met Res Shenyang 110015 Peoples R China Northeastern Univ Dept Mat Sci & Engn Shenyang 110006 Peoples R China

The tensile creep-fracture properties of DZ17G, a directionally solidified superalloy, were investigated at 830-900 degree C. The results show that all of the creep curves exhibit negligible primary creep, relatively little steady-state creep and dominant tertiary creep stage. The higher apparent activation energy for creep (540 kJ/mol) suggests that the creep is controlled by Orowan bowing process. A large ratio of the fracture time to the onset time of tertiary creep is the consequence of microstructure change, i.e., gamma ' particles oriented coarsening parallel to the applied stress axis. The creep fracture data follow the Monkman-Grant relationship. The transgranular fracture mechanism proposed on the basis of the metallographic examinations is the linkage of the creep cracks which initiate at the discontinuities with the microstructure (such as the cast porosity, and the carbide/matrix interface) and also at the specimen surface, that propagate along the gamma / gamma ' interface with perpendicular to the applied stress axis, and the process of crack propagation can be described by the Tien model. (Edited author abstract) 31 Refs.

关键词： Nickel alloys

STUDY ON COMPOSITION DESIGN OF A SUPERALLOY

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Acta Metallurgica Sinica(English Letters) 1994年第3期7卷 187-193页

作者： WANG Zhixing, XIE Shishu, yang hongcai, LIU ShiguiNortheastern University, Shenyang, China Northeastern Univ Shenyang China

A new superalloy without Co, Ta and Hf has been developed. The high temperature creep properties of the alloy approach to that of Mar-M246 superallov and with good antioxidation and anticorrosion abilities.

关键词： alloy design superalloy Mar-M246 alloy

Advances in synthetic biology-based drug delivery systems for disease treatment

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Chinese Chemical Letters 2024年第11期35卷 66-73页

作者： Yujie Li Ya-Nan Wang Yin-Gen Luo hongcai yang Jinrui Ren Xiao Li Department of Interventional Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiology the Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China

With the increasing demand for personalized and precise treatment,the rapid advancement of synthetic biology technology has inevitably led to the development of nanobiology-based drug delivery *** biology-based drug delivery systems are being increasingly used in the treatment of various *** one hand,synthetic biology technology enables the clever combination of chassis cells,bacteria,and their derivatives with nanomaterials,forming nano-artificial hybrid *** systems effectively integrate the functions of both materials,leading to further breakthroughs and optimization of biological *** the other hand,synthetic biology strategies guide the self-assembly of modular nanocomponents with biocatalytic or intelligent response functions,resulting in the mimicry of living cell features such as compartmentalization of enzymatic reactions and responsiveness to external *** provides novel design ideas for the construction of artificial *** paper aims to explore the construction and application of biogenic drug delivery systems based on whole cells,cell membrane-encapsulated nanoparticles,exosomes,bacteria,bacterial outer membrane vesicles and artificial cells,taking into account recent advances in this *** advantages and limitations of current synthetic biology-based nanodrug delivery systems for clinical translation are discussed,and the future prospects of nanotechnology for intelligent drug diagnostic and therapeutic systems are envisioned.

关键词： Drug delivery system Synthetic biology Nanotechnology Genetic engineering Nanoparticles

STRENGTH-DUCTILITY AND γ'PRECIPITATES IN Ni-BASE ALLOYS

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Acta Metallurgica Sinica(English Letters) 1995年第2期8卷 102-105页

作者： WANG Zhixing XIE Shishu LU Junying WANG Lei yang hongcai (Northeastern University,Shenyang,China ) Northeastern Univ Shenyang China

The critical diameter of γ'-phase(dc) is an important microstructural *** among the critical diameter(dc).the volume fraciton(f),the antiphase domain boundaryγenergy(APBE) ofγ'-phase and the shear modulus(G) of precipitation strengthening Ni-base alloys have been studied in this *** results show that the alloys have the strongest age-hardening effects but the lowest ductility corresponding to the critical size of γ'-*** impact ductility of the alloys relates to γ'precipitation induced volume distortion in the matrix.

关键词： Ni-base alloy precipitation hardening impact ductility volume distortion

Cholecystectomy is associated with higher risk of recurrence after microwave ablation of hepatocellular carcinoma:a propensity score matching analysis

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Cancer Biology & Medicine 2020年第2期17卷 478-491页

作者： hongcai yang Yi yang Jianping Dou Rui Cui Zhigang Cheng Zhiyu Han Fangyi Liu Xiaoling Yu Xiang Zhou Jie Yu Ping Liang School of Medicine Nankai UniversityTianjin 300071China Department of Interventional Ultrasound Chinese PLA General HospitalBeijing 100853China Department of Interventional Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:To explore the association between cholecystectomy and the prognostic outcomes of patients with hepatocellular carcinoma(H CC)who underwent microwave ablation(MWA).Methods:Patients with HCC(«=921)who underwent MWA were included and divided into cholecystectomy(n=114)and non-cholecystectomy groups(n=807).After propensity score matching(PSM)at a 1:2 ratio,overall survival(OS)and disease-free survival(DFS)rates were analyzed to compare prognostic outcomes between the cholecystectomy(«=114)and non-cholecystectomy groups(n=228).Univariate and multivariate Cox analyses were performed to assess potential risk factors for OS and *** complications were also compared between the ***:After matching,no significant differences between groups were observed in baseline *** 1-,3-,and 5-year OS rates were 96.5%,82.1%,and 67.1%in the cholecystectomy group,and 97.4%,85.2%,and 74.4%in the non-cholecystectomy group(P=0.396);the 1-,3-,and 5-year DFS rates were 58.4%,34.5%,and 26.6%in the cholecystectomy group,and 73.6%,44.7%,and 32.2%in the non-cholecystectomy group(P=0.026),*** intrahepatic distant recurrence rate in the cholecystectomy group was significantly higher than that in the non-cholecystectomy group(P=0.026),and the local tumor recurrence and extrahepatic recurrence rates did not significantly differ between the groups(P=0.609 and P=0.879).Multivariate analysis revealed that cholecystectomy(HR=1.364,95%Cl 1.023-1.819,P=0.035),number of tumors(2 vs.1:HR=2.744,95%Cl 1.925-3.912,P<0.001;3 vs.1:HR=3.411,95%Cl 2.021-5.759,P<0.001),and y-GT levels(HR=1.003,95%Cl 1.000-1.006,P<0.024)were independent risk factors for *** best y-GT level cut-off value for predicting median DFS was 39.6 U/L(area under the curve=0.600,P<0.05).A positive correlation was observed between cholecystectomy and y-GT level(r=0.108,95%Cl-0.001-0.214,P=0.047).Subgroup analysis showed that the DFS rates were significantly higher in the non-cholecystectomy

关键词： Cholecystectomy microwave ablation hepatocellular carcinoma propensity score matching

Syntheses and characterization of anti-thrombotic and anti-oxidative Gastrodin-modified polyurethane for vascular tissue engineering

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Bioactive Materials 2021年第2期6卷 404-419页

作者： Meng Zheng Jiazhi Guo Qing Li Jian yang Yi Han hongcai yang Mali Yu Lianmei Zhong Di Lu Limei Li Lin Sun Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Science and Technology Achievement Incubation CenterKunming Medical UniversityKunming650500China Department of Biomedical Engineering Materials Research InstituteThe Huck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkPA16802USA Department of Neurology The First Affiliated HospitalKunming Medical UniversityKunming650500China Department of Cardiology The Second Affiliated HospitalKunming Medical UniversityKunming650032China

Vascular grafts must avoid negative inflammatory responses and thrombogenesis to prohibit fibrotic deposition immediately upon implantation and promote the regeneration of small diameter blood vessels(<6 mm inner diameter).Here,polyurethane(PU)elastomers incorporating anti-coagulative and anti-inflammatory Gastrodin were *** films had inter-connected pores with porosities equal to or greater than 86%and pore sizes ranging from 250 to 400μ*** of Gastrodin into PU films resulted in desirable mechanical properties,hydrophilicity,swelling ratios and degradation rates without *** released Gastrodin maintained bioactivity over 21 days as assessed by its anti-oxidative *** Gastrodin/PU had better anti-coagulation response(less observable BSA,fibrinogen and platelet adhesion/activation and suppressed clotting in whole blood).Red blood cell compatibility,measured by hemolysis,was greatly improved with 2Gastrodin/PU compared to other Gastrodin/PU ***,Gastrodin/PU upregulated anti-oxidant factors Nrf2 and HO-1 expression in H2O2 treated HUVECs,correlated with decreasing pro-inflammatory cytokines TNF-αand IL-1β in RAW 264.7 *** implantation in a subcutaneous pocket,PU was encapsulated by an obvious fibrous capsule,concurrent with a large amount of inflammatory cell infiltration,while Gastrodin/PU induced a thinner fibrous capsule,especially 2Gastrodin/***,enhanced adhesion and proliferation of HUVECs seeded onto films in vitro demonstrated that 2Gastrodin/PU could help cell recruitment,as evidenced by rapid host cell infiltration and substantial blood vessel formation in *** results indicate that 2Gastrodin/PU has the potential to facilitate blood vessel regeneration,thus providing new insight into the development of clinically effective vascular grafts.

关键词： Gastrodin Polyurethane Anti-coagulation Anti-inflammation Angiogenesis

Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

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Bioactive Materials 2021年第5期6卷 1255-1266页

作者： Limei Li Mali Yu Yao Li Qing Li hongcai yang Meng Zheng Yi Han Di Lu Sheng Lu Li Gui Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Science and Technology Achievement Incubation CenterKunming Medical UniversityKunming650500China Department of Stomatology The First People’s Hospital of Yunnan ProvinceKunming650032China Department of Neurology The First Affiliated HospitalKunming Medical UniversityKunming650000China Yunnan Key Laboratory of Digital Orthopaedics Department of OrthopaedicsThe First People’s Hospital of Yunnan ProvinceKunming650032China Department of Endocrinology The Third People’s Hospital of Yunnan ProvinceKunming650011China

The development of functional materials for osteoporosis is ultimately required for bone ***,grafts were accompanied by increasing pro-inflammatory cytokines that impaired bone *** this work,nano-hydroxyapatite(n-HA)/resveratrol(Res)/chitosan(CS)composite microspheres were designed to create a beneficial microenvironment and help improve the osteogenesis by local sustained release of *** of in vitro release confirmed the feasibility of n-HA/Res/CS microspheres for controlled Res ***,microspheres had anti-inflammatory activity evidenced by the decreased expression of pro-inflammatory cytokines TNF-α,IL-1βand iNOS in RAW264.7 cells in a dose dependent ***,enhanced adhesion and proliferation of BMSCs seeded onto microspheres demonstrated that composite microspheres were conducive to cell *** ability to enhance osteo-differentiation was supported by up-regulation of Runx2,ALP,Col-1 and OCN,and substantial mineralization in osteogenic *** implanted into bone defects in the osteoporotic rat femoral condyles,enhanced entochondrostosis and bone regeneration suggested that the n-HA/Res/CS composite microspheres were more favorable for impaired fracture *** results indicated that optimized n-HA/Res/CS composite microspheres could serve as promising multifunctional fillers for osteoporotic bone defect/fracture treatment.

关键词： n-HA/Res/CS microsphere Anti-inflammation Osteo-differentiation Osteoporotic bone regeneration

Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function

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Bioactive Materials 2022年第2期7卷 355-367页

作者： hongcai yang Qing Li Limei Li Shaochun Chen Yu Zhao Yingrui Hu Lu wang Xiaoqian Lan Lianmei Zhong Di Lu Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Department of NeurologyThe First Affiliated HospitalKunming Medical UniversityKunming650500China Yunnan Key Laboratory of Stem Cell and Regenerative Medicine Science and Technology Achievement Incubation CenterKunming Medical UniversityKunming650500China The School of Rehabilitation Kunming Medical UniversityKunming650500China

Peripheral nerve regeneration and functional recovery remain a major clinical *** guidance conduit(NGC)that can regulate biological behavior of Schwann cells(SCs)and facilitate axonal regeneration through microenvironmental remodeling is beneficial for nerve regeneration and functional ***,a main constituent of a Chinese traditional herbal medicine,has been known to display several biological and pharmacological properties,especially antioxidative,anti-inflammatory and nerve ***,polyurethane(PU)NGCs modified by different weight ratio of Gastrodin(0,1 and 5 wt%)were designed for sequential and sustainable drug release,that created a favorable microenvironment for nerve *** scaffold showed suitable pore structure and biocompatibility in vitro,and evidently promoted morphological and functional recovery of regenerated sciatic nerves in *** to the PU and 1% Gastrodin/PU scaffolds,the 5% Gastrodin/PU significantly enhanced the proliferation,migration and myelination of SCs and up-regulated expression of neurotrophic factors,as well as induction of the differentiation of PC12 ***,the obvious anti-inflammatory response was observed in 5% Gastrodin/PU by reduced expression of TNF-α and iNOS,which also evidenced by the few fibrous capsule formation in the subcutaneous *** a construct presented a similarity to autograft in vivo repairing a 10 mm sciatic nerve *** was able to not only boost the regenerated area of nerve and microvascular network,but also facilitate functional axons growth and remyelination,leading to highly improved functional *** findings demonstrate that the 5% Gastrodin/PU NGC efficiently promotes nerve regeneration,indicating their potential for use in peripheral nerve regeneration applications.

关键词： Gastrodin/PU SCs biological behavior Anti-inflammatory Peripheral nerve regeneration

SINTERING BEHAVIOR OF Cu-Al ALLOY POWDER

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Acta Metallurgica Sinica(English Letters) 1995年第3期8卷 231-234页

作者： TIAN Sugui SHAO Huimeng ZHOU Longjiang LI Tiefan yang hongcai HAO Shiming(Shenyang Polytechnic University, China) (State Key Laboratory of Corrosion and Protection. Institute of Corrosion and Protection of Metals. Chinese Academy of Sciences, Shenyan Shenyang Polytechnic Univ Shenyang China

The dynamic behaviour of transient liquid phase during sintering 5wt% Al-Cu alloy compacts with green density of 7.56g/cn￣3 is observed by means of high temperature metallographic microscopy. The structures and precipitating order of the phases are identified by means of DTA, TEM and composion analysis at the definite point and phase diagram. The results show that little Al-rich liquid phase resulting from eutectic reaction flows into the capillaries in Cu powder, because the peritectic reactions exhausts the liquid in high density compact,the composition homogenization needs longer sintering time. The remainder γ2-phase is discovered at place of the neck of sintered Cu particle and has a crystallographic relationship of (111)_(Cu)∥(033)_γ_2 after alloy is sintered at 900 ℃for 3h.

关键词： transient liquid phase sintering surface reaction diffusing Cu-Al alloy