Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration

作     者：Limei Li Mali Yu Yao Li Qing Li Hongcai Yang Meng Zheng Yi Han Di Lu Sheng Lu Li Gui 

作者机构：Yunnan Key Laboratory of Stem Cell and Regenerative MedicineScience and Technology Achievement Incubation CenterKunming Medical UniversityKunming650500China Department of StomatologyThe First People’s Hospital of Yunnan ProvinceKunming650032China Department of NeurologyThe First Affiliated HospitalKunming Medical UniversityKunming650000China Yunnan Key Laboratory of Digital OrthopaedicsDepartment of OrthopaedicsThe First People’s Hospital of Yunnan ProvinceKunming650032China Department of EndocrinologyThe Third People’s Hospital of Yunnan ProvinceKunming650011China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第5期

页      面：1255-1266页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China(81460173/81860326/81960268) the Department of Science and Technology of Yunnan Province of China(2017FF117(-062)/2018FE001(-137)/2018FE001(-125)/2019ZF011-2) 

主　　题：n-HA/Res/CS microsphere Anti-inflammation Osteo-differentiation Osteoporotic bone regeneration 

摘      要：The development of functional materials for osteoporosis is ultimately required for bone ***,grafts were accompanied by increasing pro-inflammatory cytokines that impaired bone *** this work,nano-hydroxyapatite(n-HA)/resveratrol(Res)/chitosan(CS)composite microspheres were designed to create a beneficial microenvironment and help improve the osteogenesis by local sustained release of *** of in vitro release confirmed the feasibility of n-HA/Res/CS microspheres for controlled Res ***,microspheres had anti-inflammatory activity evidenced by the decreased expression of pro-inflammatory cytokines TNF-α,IL-1βand iNOS in RAW264.7 cells in a dose dependent ***,enhanced adhesion and proliferation of BMSCs seeded onto microspheres demonstrated that composite microspheres were conducive to cell *** ability to enhance osteo-differentiation was supported by up-regulation of Runx2,ALP,Col-1 and OCN,and substantial mineralization in osteogenic *** implanted into bone defects in the osteoporotic rat femoral condyles,enhanced entochondrostosis and bone regeneration suggested that the n-HA/Res/CS composite microspheres were more favorable for impaired fracture *** results indicated that optimized n-HA/Res/CS composite microspheres could serve as promising multifunctional fillers for osteoporotic bone defect/fracture treatment.