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Plasma Science and Technology 2019年第3期21卷 174-181页

作者： Tadatake SATO Kenichi TASHIRO Yoshizo KAWAGUCHI hideki OHMURA Haruhisa AKIYAMA Electronics and Photonics Research Institute National Institute of Advanced Science and Technology (AIST) Research Institute for Sustainable Chemistry National Institute of Advanced Science and Technology (AIST)

Laser-induced breakdown spectroscopy(LIBS) was examined to detect a trace substance adhered onto Al alloys for the surface inspection of materials to be adhesively bonded. As an example of Si contamination, silicone oil was employed and sprayed onto substrates with a controlled surface concentration. LIBS measurements employing nanosecond UV pulses(λ?=?266 nm) and an off-axis emission collection system with different detecting heights were performed. Because surface contaminants are involved in the plasma formed by laser ablation of the substrates, the relative contribution of the surface contaminants and the substrates to the plasma emission could be changed depending on the conditions for plasma formation. The limit of detection(LOD) was evaluated under several detecting conditions for investigating the factors that affected the LOD. A significant factor was the standard deviation values of signal intensities obtained for the clean substrates. This value varied depending on the measurement *** the Al alloy(A6061), the smallest LOD obtained was 0.529 μg?·?cm^(-2). Furthermore, an improved LOD(0.299 μg?·?cm^(-2)) was obtained for the Al alloy with a lower Si content.

关键词： laser-induced breakdown spectroscopy adhesive bonding surface contamination detection pre-bond surface inspection

Influences of the Exhaust Flow on the Boundary Layer Flow on the Wafer Surface in Spin Coating System

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Journal of Thermal Science 2005年第2期14卷 130-135页

作者： Seiichi KIMURA Mizue MUNEKATA Hiroaki KURISHIMA Kazuyoshi MATSUZAKI hideki OHBA Graduate School of Science and Technology Kumamoto University Mechanical Engineering and Materials Science Kumamoto UniversityTokyo Electron Kyushu LTDTokyo Electron AT LTDMechanical Engineering and Materials Science Kumamoto University

Recently, development of high technology has been required for the formation of thin uniform film in manufacturing processes of semiconductor as the semiconductor become more sophisticated. Spin coating is usually used for spreading photoresist on a wafer surface. However, since rotating speed of the disk is very high in spin coating, the dropped resist scatters outward and reattaches to the film surface. So, the scattered resist is removed by the exhaust flow generated at the gap between the wafer edge and the catch cup. It is seriously concerned that the stripes called Ekman spiral vortices appears on the disk in the case of high rotating speed and the film thickness increases near the wafer edge in the case of low rotating speed, because it prevent the formation of uniform film. The purpose of this study is to make clear the generation mechanism of Ekman spiral vortices and the influence of exhaust flow on it Moreover the influence of the catch cup geometry on the wafer surface boundary layer flow is investigated.

关键词： rotating disk flow spin coating boundary layer flow hot-wire measurement

Recurrent epithelial ovarian cancer and hormone therapy

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World Journal of Clinical Cases 2013年第6期1卷 187-190页

作者： Yoshihito Yokoyama hideki Mizunuma Department of Obstetrics and Gynecology Hirosaki University Graduate School of Medicine Hirosaki 036-8652 Japan

The role of hormone therapy in the treatment of ovarian cancer is not clear. Data on the efficacy and safety of antiestrogens and aromatase inhibitors in recurrent ovarian cancer have been accumulated through phase Ⅱ clinical studies. Most of these studies were conducted in platinum-resistant recurrent ovarian cancer, and although complete response rates were not high, reported adverse events were low. If administered to patients who are positive for estrogen receptors, hormone therapy may become a viable option for the treatment of recurrent ovarian cancer.

关键词： Recurrent ovarian cancer Hormone therapy Letrozole Anastrozole Tamoxifen Fulvestrant

Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 184-193页

作者： Kimthet Chhouk Wahyudiono hideki Kanda Shin-Ichro Kawasaki Motonobu Goto Department of Chemical Engineering Nagoya University Nagoya 464-8603 Japan Department of Chemical Engineering and Food Technology Institute of Technology of Cambodia Phnom Penh Cambodia Department of Materials Process Engineering Nagoya University Nagoya 464-8603 Japan Research Institute for Chemical Engineering Process Technology National Institute of Advanced Industrial Science and Technology Sendai 983-8551 Japan

Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicrobial activity. In this employed to produce the work, a swirl mixer was micronized curcumin with polyvinylpyrrolidone （PVP） by the supercritical antisolvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1：30, feed concentration of 5 mg·mL^-1, temperature of 40 ℃, pressure of 15 MPa, and CO2 flow rate of 15 mL·min^-1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.

关键词： micronization curcumin polyvinylpyrrolidone supercritical anti-solvent swirl mixer

Application of yeast spores as β-glucan particles

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Particuology 2022年第12期71卷 34-40页

作者： Guoyu Liu Yan Yang Hiroyuki Tachikawa Xiao-Dong Gao hideki Nakanishi Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Department of Applied Biological Chemistry Graduate School of Agricultural and Life SciencesUniversity of TokyoTokyo 113-8657Japan Collaborative Research Institute for Innovative Microbiology University of TokyoTokyo 113-8657Japan

β-Glucan exhibits various beneficial biological activities including *** polysaccha-ride is present in the cell wall of microorganisms including the yeast Saccharomyces *** vegetative yeast cells are used as dietary supplements,β-glucan in the vegetative cell wall is covered with *** nutrient starvation,yeast cells differentiate into dormant cell spores.β-Glucan is also present in the spore wall,but spores have been poorly studied as application *** spore wall consists of four layers andβ-glucan forms the third layer from the ***,unlike vegeta-tive cells,theβ-glucan layer can be exposed to the cell surface in spores by genetic *** example,chs3Δmutant spores exhibit such a spore wall ***-1 is the primary receptor forβ-glucan in mammals and,its activation induces phagocytosis and proinflammatory cytokine *** found that chs3Δspores are phagocytosed in mammalian cells in a manner dependent on dectin-1 and induce higher levels of TNF-αand IL-6 than vegetative *** results demonstrate that chs3Δspores areβ-glucan particles with immunostimulatory ***,they would be attractive materials for application in the food industry.

关键词： Saccharomycescerevisiae Sporewall β-glucan Dectin-1 Immunostimulation

Lateral load pattern in pushover analysis

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Earthquake Engineering and Engineering Vibration 2003年第1期2卷 99-108页

作者：孙景江 Tetsuro ono 赵衍刚王威 Institate of Engineering Mechanics China Seismological BureauHarbin 150080China Professor Department.of Architecture Nagoya Institute of TechnologyNagoya 466-8555Japan Professor Department.of Architecture Nagoya Institute of TechnologyNagoya 466-8555Japan Associate Professor Institute of Engineering Mechanics China Seismological BureauHarbin 150080China Assistant Professor

The seismic capacity curves of three types of buildings including frame,frame-shear wall and shear wall ob- tained by pushover analysis under different lateral load patterns are compared with those from nonlinear time history analy- *** on the numerical results obtained a two-phase load pattern:an inverted triangle(first mode)load pattern until the base shear force reaches β times its maximum value,V_(max)followed by a(x/H)~α form,here β and α being some coeffi- cients depending on the type of the structures considered,is proposed in the paper,which can provide excellent approxima- tion of the seismic capacity curve for low-to-mid-rise shear type ***,it is shown both the two-phase load pattern proposed and the invariant uniform pattern can be used for low-to-mid-rise shear-bending type and low-rise bending type of *** suitable load patterns have been found for high-rise buildings.

关键词： pushover analysis performance-based seismic design lateral load pattern nonlinear time history analysis

One-Stage Correction with Intra- and Extraatrial Rerouting of Anomalous Systemic and Pulmonary Venous Return and Intraventricular Repair of Double Outlet Right Ventricle in a Patient with Heterotaxy Syndrome

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Congenital Heart Disease 2022年第1期17卷 25-30页

作者： Helena Staehler Carina Hopfner Masamichi ono Jurgen Horer Department of Congenital and Pediatric Heart Surgery German Heart Center MunichTechnische Universitat MünchenDivision of Congenital and Pediatric Heart SurgeryUniversity Hospital of MunichLudwig-Maximilians-UniversitatMunichGermany Department of Pediatric Cardiology and Pediatric Intensive Care University Hospital of MunichLudwig-Maximilians-UniversitatMunichGermany

We report a very rare case of successful intracardiac correction in a patient with heterotaxy *** cardiac malformations included dextrocardia,double outlet right ventricle,pulmonary stenosis,interrupted inferior vena cava,hemiazygos continuation and total anomalous pulmonary venous ***-stage correction was *** atrial procedure consisted of intra-and extraatrial rerouting of the anomalous systemic and pulmonary venous *** hepatic veins were detached and diverted to the left atrium via an extracardiac *** correction of the double outlet right ventricle was accomplished by intraventricular redirection of the blood flow from the left ventricle to the *** right ventricular outflow was ultimately remodeled using a valved *** better perception of the complex morphology,a three-dimensional model was designed,using CT scan *** proved to be very useful for surgical planning,especially with regard to the intraatrial reconstruction of the systemic and pulmonary venous rerouting.

关键词： Heterotaxy syndrome anomalous systemic venous return anomalous pulmonary venous return azygos continuation double outlet right ventricle 3D modeling

Organic additive engineering toward efficient perovskite light-emitting diodes

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InfoMat 2020年第6期2卷 1095-1108页

作者： Yuqiang Liu Luis K.ono Yabing Qi Energy Materials and Surface Sciences Unit(EMSSU) Okinawa Institute of Science and Technology Graduate University(OIST)OkinawaJapan

Perovskite materials with excellent optical and electrical properties are promising for light-emitting *** the field of perovskite light-emitting diodes(PeLEDs),organic materials additive engineering has been proved to be an effective scheme for enhancing efficiency and stability in *** impressively,the reported external quantum efficiency of PeLEDs based on perovskite-organic composite has reached over 20%.Herein,we will review the important progress of the organic materials'additive-modified PeLEDs and discuss the remaining problems and challenges and the key research direction in the near future.

关键词： perovskite light-emitting diodes organic additive stability

Statistical modeling of nitrogen-dependent modulation of root system architecture in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2016年第3期58卷 254-265页

作者： Takao Araya Takuya Kubo Nicolaus von Wiren hideki Takahashi Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingM148824USA Molecular Plant Nutrition Leibniz Institute of Plant Genetics and Crop Plant ResearchD-06466 GaterslebenGermany Graduate School of Environmental Science Hokkaido UniversitySapporo 060-0810Japan

Plant root development is strongly affected by nutrient availability. Despite the importance of structure and function of roots in nutrient acquisition,statistical modeling approaches to evaluate dynamic and temporal modulations of root system architecture in response to nutrient availability have remained as widely open and exploratory areas in root biology. In this study,we developed a statistical modeling approach to investigate modulations of root system architecture in response to nitrogen availability. Mathematical models were designed for quantitative assessment of root growth and root branching phenotypes and their dynamic relationships based on hierarchical con figuration of primary and lateral roots formulating the fishbone-shaped root system architecture in Arabidopsis thaliana. Time-series datasets reporting dynamic changes in root developmental traits on different nitrate or ammonium concentrations were generated for statistical analyses. Regression analyses unraveled key parameters associated with：（i） inhibition of primary root growth under nitrogen limitation or on ammonium;（ii） rapid progression of lateral root emergence in response to ammonium; and（iii） inhibition of lateral root elongation in the presence of excess nitrate or ammonium. This study provides a statistical framework for interpreting dynamic modulation of root system architecture,supported by metaanalysis of datasets displaying morphological responses of roots to diverse nitrogen supplies.

关键词： Ammonium mathematical modeling nitrate nitrogen root system architecture

Electrical demand aggregation effects on the performance of deep learning-based short-term load forecasting of a residential building

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Energy and AI 2022年第2期8卷 30-49页

作者： Ayas Shaqour Tetsushi ono Aya Hagishima Hooman Farzaneh Interdisciplinary Graduate School of Engineering Sciences Kyushu University6 Chome-1 KasugakoenKasugaFukuoka 816-8580Japan Hitachi Ltd.Research&Development GroupTokyoJapan

Modern power grids face the challenge of increasing renewable energy penetration that is stochastic in nature and calls for accurate demand predictions to provide the optimized power ***,increasing the self-consumption of renewable energy through demand response in households,local communities,and micro-grids is essential and calls for high demand prediction performance at lower levels of demand aggregations to achieve optimal *** many of the recent studies have investigated both macro and micro scale short-term load forecasting(STLF),a comprehensive investigation on the effects of electrical demand aggregation size on STLF is minimal,especially with large sample sizes,where it is essential for optimal sizing of residential micro-grids,demand response markets,and virtual power ***,this study comprehensively investigates STLF of five aggregation levels(3,10,30,100,and 479)based on a dataset of 479 residential dwellings in Osaka,Japan,with a sample size of(159,47,15,4,and 1)per level,respectively,and investigates the underlying challenges in lower aggregation *** deep learning(DL)methods are utilized for STLF and fine-tuned with extensive methodological sensitivity analysis and a variation of early stopping,where a detailed comparative analysis is *** test results reveal that a MAPE of(2.47-3.31%)close to country levels can be achieved on the highest aggregation,and below 10%can be sustained at 30 aggregated ***,the deep neural network(DNN)achieved the highest performance,followed by the Bi-directional Gated recurrent unit with fully connected layers(Bi-GRU-FCL),which had close to 15%faster training time and 40%fewer learnable parameters.

关键词： Bidirectional gated recurrent units Convolutional neural network Deep Neural Networks Recurrent neural network Residential load aggregation Short-term load forecasting