Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer
Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer作者机构：Department of Chemical Engineering Nagoya University Nagoya 464-8603 Japan Department of Chemical Engineering and Food Technology Institute of Technology of Cambodia Phnom Penh Cambodia Department of Materials Process Engineering Nagoya University Nagoya 464-8603 Japan Research Institute for Chemical Engineering Process Technology National Institute of Advanced Industrial Science and Technology Sendai 983-8551 Japan
出 版 物：《Frontiers of Chemical Science and Engineering》 (化学科学与工程前沿（英文版）)
年 卷 期：2018年第12卷第1期
页 面：184-193页
核心收录：
学科分类：0820[工学-石油与天然气工程] 080706[工学-化工过程机械] 08[工学] 0807[工学-动力工程及工程热物理] 082002[工学-油气田开发工程]
基 金：supported by ASEAN University Network for Southeast Asia Engineering Education Development Network (AUN/SEED-Net) the Japan International Cooperation Agency (JICA) the Precursory Research for Embryonic Science and Technology Program of the Japan Science and Technology Agency (JST)
主 题：micronization curcumin polyvinylpyrrolidone supercritical anti-solvent swirl mixer
摘 要：Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicrobial activity. In this employed to produce the work, a swirl mixer was micronized curcumin with polyvinylpyrrolidone （PVP） by the supercritical antisolvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1：30, feed concentration of 5 mg·mL^-1, temperature of 40 ℃, pressure of 15 MPa, and CO2 flow rate of 15 mL·min^-1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.
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