Application of yeast spores as β-glucan particles
作者机构：Key Laboratory of Carbohydrate Chemistry and BiotechnologyMinistry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Department of Applied Biological ChemistryGraduate School of Agricultural and Life SciencesUniversity of TokyoTokyo 113-8657Japan Collaborative Research Institute for Innovative MicrobiologyUniversity of TokyoTokyo 113-8657Japan
出 版 物：《Particuology》 (颗粒学报（英文版）)
年 卷 期：2022年第71卷第12期
页 面：34-40页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：This work is supported by National First-class Discipline Program of Light Industry Technology and Engineering(LITE2018-015) Project 111(111-2-06) Collaborative Innovation Center of jiangsu Modern Industrial Fermentation,International Joint Research Laboratory for production of therapeutic glycoproteins at Jiangnan University to X.-D.Gao Fundamental Research Funds for the Central Universities to H.Nakanishi(JUSRP51629B) National Natural Science Foundation of China grants to H.Nakanishi(32071467)and X.-D.Gao(21778023)
主 题：Saccharomycescerevisiae Sporewall β-glucan Dectin-1 Immunostimulation
摘 要：β-Glucan exhibits various beneficial biological activities including *** polysaccha-ride is present in the cell wall of microorganisms including the yeast Saccharomyces *** vegetative yeast cells are used as dietary supplements,β-glucan in the vegetative cell wall is covered with *** nutrient starvation,yeast cells differentiate into dormant cell spores.β-Glucan is also present in the spore wall,but spores have been poorly studied as application *** spore wall consists of four layers andβ-glucan forms the third layer from the ***,unlike vegeta-tive cells,theβ-glucan layer can be exposed to the cell surface in spores by genetic *** example,chs3Δmutant spores exhibit such a spore wall ***-1 is the primary receptor forβ-glucan in mammals and,its activation induces phagocytosis and proinflammatory cytokine *** found that chs3Δspores are phagocytosed in mammalian cells in a manner dependent on dectin-1 and induce higher levels of TNF-αand IL-6 than vegetative *** results demonstrate that chs3Δspores areβ-glucan particles with immunostimulatory ***,they would be attractive materials for application in the food industry.
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