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Tsinghua Science and Technology 2006年第2期11卷 160-164页

作者： gary Kordosky Michael Virnig Burrel Boley Cognis Corporation Tucson Arizona USA

The development of pressure and bioleaching processes for high grade copper ores and concentrates will result in copper solvent extraction plants treating solutions with high copper and acid concentrations at temperatures up to 45℃ and these copper solvent extraction plants will run with reagent concentrations up to 40 vol.%. There is also a trend to use copper stripping solutions with less acid than typically used in recent years. Cognis has developed a model that accurately predicts the copper strip point for virtually any copper solvent extraction reagent or combination of reagents under a wide variety of conditions. The equilibrium strip points for several well known commercial copper solvent extraction reagents are given as a function of reagent concentration, the copper and acid concentration of the strip aqueous, and the temperature. It is shown that the equilibrium strip point is not a straight line function of reagent concentration and that the equilibrium strip point increases with an increase in temperature. Copper extraction also increases as the temperature increases.

关键词： equilibrium strip point solvent extraction plants bioleaching process

Animal models for filovirus infections

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Zoological Research 2018年第1期39卷 15-24页

作者： Vinayakumar Siragam gary Wong Xiang-Guo Qiu Special Pathogens Program Public Health Agency of CanadaWinnipegManitoba R3E 3R2Canada Department of Medical Microbiology University of ManitobaWinnipegManitoba R3E 0J9Canada Shenzhen Key Laboratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhen Guangzhou 51 8020China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates （NHPs）, causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.

关键词： Filovirus Ebola virus Marburg virus Marburg virus disease Ebola virus disease Mouse-adapted ebolavirus Guinea-pig-adapted ebolavirus Sudan virus Plaque-forming units

Regulation of cell adhesion in the testis： a new role for p73

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Asian Journal of Andrology 2014年第6期16卷 799-800页

作者： Helen E Abud gary R Hime Department of Anatomy and Developmental Biology Monash University Clayton VIC 3800 Australia Department of Anatomy and Neuroscience University of Melbourne Parkville VIC 3010Australia.

The dramatic changes that male germ cells in the adult testis undergo in gene expression profile and morphology as they transition from spermatogonial stem cells through to mature spermatozoa is dependent upon their association with Sertoli cells. Sertoli cells are crucial for survival and maturation of male germ cells. Two recent papers, Holembowski et al？ and Inoue et a13 have described a surprising role for the p53 family member, p73, in regulation of germ cell-Sertoli cell adhesion.

关键词： TUMOR-SUPPRESSOR P63 SPERMATOGENESIS TAP73 DEATH P53

Influence of the Atlantic Multidecadal Oscillation on the Winter Climate of East China

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Advances in Atmospheric Sciences 2007年第1期24卷 126-135页

作者：李双林 gary T.BATES Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 NOAA ESRL-CIRES Climate Diagnostics CenterUniversity of ColoradoBoulderColorado NOAA ESRL-CIRES Climate Diagnostics Center University of ColoradoBoulderColorado

The Atlantic Multidecadal Oscillation （AMO）, the multidecadal variation of North Atlantic sea surface temperature （SST）, exhibits an oscillation with a period of 65-80 years and an amplitude of 0.4℃. Observational composite analyses reveal that the warm phase AMO is linked to warmer winters in East China, with enhanced precipitation in the north of this region and reduced precipitation in the south, on multidecadal time scales. The pattern is reversed during the cold phase AMO. Whether the AMO acts as a forcing of the multidecadal winter climate of East China is explored by investigating the atmospheric response to warm AMO SST anomalies in a large ensemble of atmospheric general circulation model （AGCM） experiments. The results from three AGCMs are consistent and suggest that the AMO warmth favors warmer winters in East China. This influence is realized through inducing negative surface air pressure anomalies in the hemispheric-wide domain extending from the midlatitude North Atlantic to midlatitude Eurasia. These negative surface anomalies favor the weakening of the Mongolian Cold High, and thus induce a weaker East Asian Winter Monsoon.

关键词： Atlantic Multidccadal Oscillation winter climate East China

Information Science Roles in the Emerging Field of Data Science

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Journal of Data and Information Science 2016年第2期1卷 1-6页

作者： gary Marchionini School of Information and Library Science University of North Carolina at Chapel Hill

There has long been discussion about the distinctions of library science,information science,and informatics,and how these areas differ and overlap with computer *** the term data science is emerging that generates ex... 详细信息

关键词： Information Science Roles in the Emerging Field of Data Science

The presence of functional blood vessels in the ischemic core provides a therapeutic target for stroke recovery

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Neural Regeneration Research 2023年第12期18卷 2653-2654页

作者： gary P.Morris Brad A.Sutherland Tasmanian School of Medicine College of Health and MedicineUniversity of TasmaniaHobartTasmaniaAustralia

Ischemic stro ke occurs when a blood vessel in the brain is *** the immediate *** flow becomes deficient in regions supplied by the blocked *** leads to the development of a core region,where blood flow is reduced to <30% and injury occurs rapidly,and a penumbral region,where blood flow is reduced to a level that is not capable of supporting neuronal function,but is sufficient to maintain cell viability(Morris et al.,2023).

关键词： al. therapeutic maintain

A model of regional economic development with increasing returns

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 164-170页

作者： QIAN Edward Y. YAO Yao-jun CHEN gary Center for Research of Private Economy Zhejiang University Hangzhou 310027 China College of Finance Zhejiang Gongshang University Hangzhou 310018 China Department of Management Setenee University of Waterloo Waterloo ON N2L 3G1 Canada

This paper develops mathematically and empirically tractable regional and interregional model of economic devel-opment with increasing returns to scale (IRS) under the neoclassical assumptions. A one-sector, two-region model in which one region exhibits IRS is presented and the whole nation presents constant returns to scale. The development of the local IRS economy is shown to be constrained to a “moving equilibrium” path. The preliminary empirical results are sufficiently supportive of the argument to encourage further research along the lines of the model. In particular, the neoclassical model does not predict negative coefficients on the real rental value of capital in regressions explaining population or employment relative to that in the nation.

关键词： Economic development Increasing returns Moving equilibrium

Age of onset of diabetes and all-cause mortality

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World Journal of Diabetes 2020年第4期11卷 95-99页

作者： gary Yee Ang Health Services and Outcomes Research National Healthcare GroupSingapore 138543Singapore

Diabetes mellitus continues to present a large social,financial and health system burden across the *** relationship between age of onset of the different types of diabetes and all-cause mortality is *** this review paper,the relationship between age of onset of the different types of diabetes and all-cause mortality will be reviewed and an update of the current evidence will be *** is strong evidence of the relationship between age of onset of type 2 diabetes mellitus(T2 DM) and all-cause mortality,good evidence of the relationship between age of onset of T1 DM and all-cause mortality and no evidence of the relationship between age of onset of gestational diabetes or prediabetes and all-cause *** research is needed to look at whether aggressive management of earlier onset of T2 DM can help to reduce premature mortality.

关键词： Diabetes mellitus Age of onset Mortality Type 1 diabetes Type 2 diabetes Gestational diabetes Prediabetes

Prenatal risk factors for internalizing and externalizing problems in childhood

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World Journal of Pediatrics 2020年第4期16卷 341-355页

作者： Joyce Tien gary D.Lewis Jianghong Liu Department of Family and Community Health School of NursingUniversity of PennsylvaniaPhiladelphiaPA19104USA University of Arkansas for Medical Sciences Little RockARUSA

Background A growing body of research has documented the effects of prenatal risk factors on a wide spectrum of adverse offspring health *** behavior problems,such as externalizing and internalizing problems,are no *** comprehensive literature review aims to summarize and synthesize current research about commonly experienced prenatal risk factors associated with internalizing and externalizing problems,with a focus on their impact during childhood and *** mechanisms as well as implications are also *** sources The EBSCO,Web of Science,PubMed,Google Scholar,and Scopus databases were searched for studies examining the association between prenatal risk factors and offspring internalizing/externalizing problems,using keywords“prenatal”or“perinatal”or“birth complications”in combination with“internalizing”or“externalizing”.Relevant articles,including experimental research,systematic reviews,meta-analyses,cross-sectional and longitudinal cohort studies,and theoretical literature,were reviewed and synthesized to form the basis of this integrative *** Prenatal risk factors that have been widely investigated with regards to offspring internalizing and externalizing problems encompass health-related risk factors,including maternal overweight/obesity,substance use/abuse,environmental toxicant exposure,maternal infection/inflammation,as well as psychosocial risk factors,including intimate partner violence,and anxiety/***,both epidemiological and experimental studies support the adverse associations between these prenatal factors and increased risk of emotional/behavioral problem development during childhood and *** mechanisms of action underlying these associations include hormonal and immune system *** include prenatal education,screening,and intervention *** Prenatal risk factors are associated with a constellation of offspring internalizin

关键词： Externalizing Internalizing Obstetrical Pregnancy Prenatal risk factors

Reversibility of diabetes mellitus: Narrative review of the evidence

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World Journal of Diabetes 2018年第7期9卷 127-131页

作者： gary Yee Ang Health Services and Outcomes Research National Healthcare Group

The global disease burden of diabetes mellitus is high. It is well-established that prediabetes is reversible but it is unclear whether diabetes is reversible once it has been diagnosed. The objective of this narrative review is to review the evidence of reversibility of diabetes me-llitus and stimulate interest in prolonged remission as a treatment target. The current evidence for bariatric surgery is stronger than intensive medical management and the evidence is stronger for type 2 diabetes pa-tients compared with type 1 diabetes patients. It is also unclear whether non obese diabetes patients would benefit from such interventions and the duration of diabetes before diabetes become irreversible. Further research is needed in this area especially with regards to the subgroup of diabetes patient who will benefit from these interventions and the long term safety and efficacy remains unknown especially with intensive me-dical management.

关键词： Diabetes Reversibility Remission Bariatric surgery Obesity