Animal models for filovirus infections

作     者：Vinayakumar Siragam Gary Wong Xiang-Guo Qiu 

作者机构：Special Pathogens ProgramPublic Health Agency of CanadaWinnipegManitoba R3E 3R2Canada Department of Medical MicrobiologyUniversity of ManitobaWinnipegManitoba R3E 0J9Canada Shenzhen Key Laboratory of Pathogen and ImmunityState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalShenzhen Guangzhou 51 8020China Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of SciencesBeijing 100101China 

出 版 物：《Zoological Research》 (动物学研究（英文）)

年 卷 期：2018年第39卷第1期

页      面：15-24页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：supported by the Public Health Agency of Canada(PHAC) partially supported by the NIH and CIHR grants to X.G.Qiu(U19 AI109762-1 and CIHR-IER-143487,respectively) the National Natural Science Foundation of China International Cooperation and Exchange Program(8161101193) National Science and Technology Major Project(2016ZX10004222)to G.Wong 

主　　题：Filovirus Ebola virus Marburg virus Marburg virus disease Ebola virus disease Mouse-adapted ebolavirus Guinea-pig-adapted ebolavirus Sudan virus Plaque-forming units 

摘      要：The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates （NHPs）, causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.