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Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

Nano Research 2015年第10期8卷 3307-3315页

作者： Daniela P. Lobo Alan M. Wemyss David J. Smith Anne Straube Kai B. Betteridge Andrew H. J. Salmon Rebecca R. foster Hesham E. Elhegni Simon C. Satchell Haydn A. Little Raul Pacheco-gomez Mark J. Simmons Matthew R. Hicks David O. Bates Alison Rodger Timothy R. Dafforn Kenton P. Arkill DepartmentofChemistryandWarwickAnalyticalScienceCentre UniversityofWarwickCoventryCV47ALUK MOACDoctoralTrainingCentre UniversityofWarwickCoventryCV47ALUK Mathematics UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK CentreforMechanochemicalCellBiology WarwickMedicalSchoolUniversityofWarwickCoventryCV47ALUK PhysiologyandPharmacology UniversityofBristolUniversityWalkBristolBS81TDUK ClinicalSciences WhitsonStreetUniversityofBristolBristolBS13NYUK SchoolofChemistry UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK Biosciences UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK ChemicalEngineering UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK SchoolofMedicine UniversityofNottinghamQueen'sMedicalCentreNottinghamNG27UHUK Biochemistry UniversityofBristolUniversityWalkBristolBS81TDUK

The wall shear stress （WSS） that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology （e.g. angiogenesis） and affects the microvasculature＇s primary function of molecular transport. Points of fluctuating WSS show abnormalities in a number of diseases; however, there is no established technique for measuring WSS directly in physiological systems. All current methods rely on estimates obtained from measured velocity gradients in bulk flow data. In this work, we report a nanosensor that can directly measure WSS in microfluidic chambers with sub-micron spatial resolution by using a specific type of virus, the bacteriophage M13, which has been fluorescently labeled and anchored to a surface. It is demonstrated that the nanosensor can be calibrated and adapted for biological tissue, revealing WSS in micro-domains of cells that cannot be calculated accurately from bulk flow measurements. This method lends itself to a platform applicable to many applications in biology and microfluidics.

关键词： microfluidics nanoparticle M13 bacteriophage wall shear stress fluorescent microscopy

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Multimodality functional imaging using DW-MRI and 18f-fDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience

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World Journal of Radiology 2017年第1期9卷 17-26页

作者： David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias francisco Salvador gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz Department of Medical Physics and Radiological Protection Galaria - MeixoeiroUniversity Hospital Complex of Vigo Department of Medical Physics Memorial Sloan-Kettering Cancer Center Department of Radiology Complutense University Department of Medical Physics Department of Radiology Memorial Sloan-Kettering Cancer Center Department of Radiation Oncology Galaria - MeixoeiroUniversity Hospital Complex of Vigo

AIMTo noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging (DW-MRI) and glucose metabolism measured by 18f-labeled fluorodeoxyglucose positron emission tomography/computed tomography (18f-fDG-PET/CT) during radiation therapy (RT) for human papillomavirus negative (HPV-) head and neck squamous cell carcinoma (HNSCC).METHODSIn this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during- (2-3 wk), and post-treatment (Tx), and 18f-fDG PET/CT pre- and post-Tx (n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient (ADC) and the mean of standardized uptake value (SUV) was measured from 18f-fDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 *** was a strong negative correlation between the mean of pretreatment ADC (ρ = -0.67, P = 0.01) and the pretreatment 18f-fDG PET SUV. The percentage (%) change in delta (∆) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with *** results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience.

关键词： Diffusion-weighted magnetic resonance imaging Human papillomavirus negative head and neck squamous cell carcinoma 18f-labeled fluorodeoxyglucose positron emission tomography/computed tomography

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Impact of formal training in endoscopic submucosal dissection for early gastrointestinal cancer: A systematic review and a meta-analysis

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World Journal of Gastrointestinal Endoscopy 2015年第4期7卷 417-428页

作者： Miguel A Tanimoto M Lourdes Guerrero Yoshinori Morita Jonathan Aguirre-Valadez Elisa gomez Carlos Moctezuma-Velazquez Jose A Estradas-Trujillo Miguel A Valdovinos Luis f Uscanga Rikiya fujita National Institute of Medical Sciences and Nutrition Salvador Zubiran Kobe University School of Medicine Department of Gastroenterology National Institute of Medical Sciences and Nutrition Salvador Zubiran Yokohama Shin-midori General Hospital

AIM: To summarize the clinical impact of a formal training for the effectiveness and safety of endoscopic submucosal dissection for gastrointestinal ***: We searched databases including PubM ed, EMBASE and the Cochrane Library and Science citation Index updated to August 2014 to include eligible articles. In the Meta-analysis, the main outcome measurements were en bloc resection rate, local recurrence rate(R0) and the incidence of procedure-related complications(perforation, bleeding). RESULTS: En bloc resection was high for both, dissecting stomach tumors with an overall percentage of 93.2%(95%CI: 90.5-95.8) and dissecting colorectal tumors with an overall percentage of 89.4%(95%CI: 85.1-93.7). Although the number of studies reporting R0 resection(the dissected specimen was revealed free of tumor in both vertical and lateral margins) was small, the overall estimates for R0 resection were 81.4%(95%CI: 72-90.8) for stomach and 85.9%(95%CI: 77.5-95.5) for colorectal tumors, respectively. The analysis showed that the percentage of immediate perforation and bleeding were very low; 4.96(95%CI: 3.6-6.3) and 1.4%(95%CI: 0.8-1.9) for colorectal tumors and 3.1%(95%CI: 2.0-4.1) and 4.8%(95%CI: 2.8-6.7) for stomach tumors, respectively. CONCLUSION: In order to obtain the same rate of success of the analyzed studies it is a necessity to create training centers in the western countries during the "several years" of gastroenterology residence first only to teach EGC diagnose and second only to train endoscopic submucosal dissection.

关键词： Endoscopic submucosal dissection Training

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Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells： role of autophagic cell death

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中国神经肿瘤杂志 2007年第3期5卷 168-168页

作者： Jiang H gomez-Manzano C Aoki H Alonso MM Kondo S McCormick f Xu J Kondo Y Bekele BN Colman H Lang ff fueyo J Brain Tumor Center The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd Houston TX 77030 USA.

The eradication of brain tumor stem cells is essential for long-term brain tumor remission after *** this study, we examined the therapeutic potential of an oncolytic adenovirus, Deha-24-RGD, targeted to the abnormal p16INK4/Rb pathway in brain tumor stem *** brain tumor stem cell lines from surgical glioblastoma specimens expressed high levels of adenoviral receptors and allowed for efficient viral infection, replication, and oncolysis in an Rb-dependent ***-24-RGD induced autophagic cell death, as indicated by accumulation of Atg5 and LC3-Ⅱprotein and autophagic vacuoles.

关键词：治疗脑肿瘤干细胞自我吞噬作用细胞死亡

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实时动态定位低成本试验应用提高粮食作物效益

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中国农业文摘（农业工程） 2022年第1期34卷 64-64页

作者： Tayebi A gomez J fernández M de Adana f S Gutiérrez O 不详

传统农业在世界范围内面临着若干挑战,如人口增长、林业和城市化迅速发展、资源匮乏、气候变化、环境污染、以及不同市场之间的竞争。因此,农民需要提高生产率,以保持产出水平。该研究试图通过在种植谷物时进行的一系列实际测量,评估在... 详细信息

传统农业在世界范围内面临着若干挑战,如人口增长、林业和城市化迅速发展、资源匮乏、气候变化、环境污染、以及不同市场之间的竞争。因此,农民需要提高生产率,以保持产出水平。该研究试图通过在种植谷物时进行的一系列实际测量,评估在精准农业中使用实时动态(RTK)定位的益处。谷物种植过程中涉及的所有农业管理行为(休耕、耕作、播种、施肥、割草和收割)均使用自动导航系统辅助完成,从而降低了成本。

关键词：产出水平资源匮乏自动导航系统实时动态定位精准农业粮食作物气候变化提高生产率

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fretting fatigue Evaluation Produced by A New Vertical Machine

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材料科学与工程（中英文版） 2010年第2期4卷 26-38页

作者： GuiUermo Urriolagoitia-Sosa Guillermo Urriolagoitia-Calderon Luis Hector Hemaindez-gomez Beatriz Romero-Angeles Secci6n de Estudios de Posgrado e lnvestigacion Escuela Superior de lngenieria Mecanica y Electrica lnstituto Politecnico Nacional Unidad Profesional Adolfo Lopez Mateos 5th Building 2nd Floor Lindavista CP 07738 Gustavo A. Madero Mexico D F. Mexico.

It has been well documented in the open literature that fretting fatigue tests are generally performed on machines with horizontal configuration. This kind of configuration has the problem of misalignment between the actuator and the specimen. The misalignment generally occurs on the support of the actuator, which is held by a solid bar in a cantilever beam configuration, caused by the fretting fatigue effect. The present work describes the design and construction of a new vertical fretting fatigue machine. The intention of this work is to solve the misalignment problem observed in the horizontal configuration and to explore the advantages and disadvantages offered by the vertical configuration. In this work, uni-axial and fretting fatigue experiments were run to evaluate the performance of the new apparatus and all the fretting tests were done in a partial slip regime, so that the relative displacement within the contact could be calculated. furthermore, in this research the damage caused by the relative slip fretting was investigated and the performance of the new vertically mounted coaxial fretting fatigue machine was assessed. The results with compared were those obtained in a horizontal configuration machine and have provided complete confidence on the new design.

关键词：微动疲劳疲劳评价加工生产疲劳试验机立式悬臂梁结构垂直式相对位移

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日粮蛋白和纤维水平对仔猪生产性能和健康状况的影响

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饲料与畜牧（新饲料） 2009年第11期 55-55页

作者：刘冰 R.G.Hermes f.Molist M.Ywazaki M.Nofrarías A.gomez de Segura J.Gasa J.f.Pérez

为了研究日粮蛋白和纤维水平间的相互作用对仔猪生产性能和健康状况的影响,96只35日龄仔猪（9.11±0.60kgBW）被分成32圈,每圈3头;试验共设4个日粮处理,试验期21d。4种日粮处理采用2×2因子设计（稻谷、乳制品、豆粕）,共设2个粗蛋白水... 详细信息

为了研究日粮蛋白和纤维水平间的相互作用对仔猪生产性能和健康状况的影响,96只35日龄仔猪（9.11±0.60kgBW）被分成32圈,每圈3头;试验共设4个日粮处理,试验期21d。4种日粮处理采用2×2因子设计（稻谷、乳制品、豆粕）,共设2个粗蛋白水平（15.4%,19.4%）和2个粗纤维水平（15．4％，19．4％）和2个粗纤维水平（Df；低纤维（Lf）5．3％NDf；

关键词：日粮纤维仔猪蛋白甜菜碱渣小麦麸

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Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis

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World Journal of Gastroenterology 2015年第30期21卷 9163-9174页

作者： Javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-gomez Jose Maria Navarro Milagros Testillano Conrado fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons francisco Jorquera francisco Javier Rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles CIBERehd Instituto de Salud Carlos Ⅲ28029 MadridSpain Unit for Clinical Management of Digestive Diseases Complejo Hospitalario Universitario de Granada Instituto de Investigacion Biosanitaria de Granada University Hospital Politecnico La fe Unit for Clinical Management of Digestive Diseases University Hospital Virgen Del Rocio Hospital Toledo University Clinic Hospital of Valencia University General Hospital of Valencia Unit for Clinical Management of Digestive Diseases University Hospital Nuestra Senora de Valme Department of Gastroenterology and Hepatology Agencia Sanitaria Costa del Sol University Hospital Cruces Gastroenterology Unit University Hospital Fundacion Alcorcon University Hospital Virgen Macarena University Hospital Virgen de la Arrixaca Hospital of Leon University General Hospital Reina Sofia Department Gastroenterology and Hepatology University Hospital Central de Asturias University Hospital Reina Sofia University Hospital De Gran Canaria Dr. Negrin Hospital San Pedro de Alcantara

AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow ***:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P fied intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were f4 and the highest SVR rates were recorded in the non-f4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-f4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the f4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was

关键词： Hepatitis C Boceprevir Telaprevir first-generation protease inhibitors Advanced fibrosis

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Search for the doubly heavy baryons Ωbc0 and Ξbc0 decaying to Λc+π- and Ξc+π-

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Chinese Physics C 2021年第9期45卷 14-25页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht f.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti f.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini f.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker f.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt f.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch f.C.R.Bishop A.Bitadze A.Bizzeti M.Bj?rn M.P.Blago T.Blake f.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo gomez P.Camargo Magalhaes A.Camboni P.Campana A.f.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.f.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovská M.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo J.Dalseno C.D'Amb University of Edinburgh Horia Hulubei National Institute of Physics and Nuclear Engineering INfN Sezione di Bari Università di Bari Los Alamos National Laboratory (LANL) Van Swinderen Institute University of Groningen Universiteit Maastricht AGH-University of Science and Technology faculty of Physics and Applied Computer Science Université Clermont Auvergne Università di Cagliari Institute for Nuclear Research of the National Academy of Sciences (KINR) School of Physics University College Dublin NSC Kharkiv Institute of Physics and Technology (NSC KIPT) INfN Sezione di Perugia STfC Rutherford Appleton Laboratory School of Physics and Astronomy Monash University Novosibirsk State University CNRS/IN2P3 Department of Physics and Astronomy Uppsala University Università di Genova School of Physics State Key Laboratory of Nuclear Physics and Technology Peking University National Center for Nuclear Research (NCBJ) Università di Roma Tor Vergata Pontifícia Universidade Católica do Rio de Janeiro (PUC-Rio) Universidade federal do Triangulo Mineiro (UfTM) Institute of Particle Physics LPC Central China Normal University Hangzhou Institute for Advanced Study UCAS Instituto de fisica Corpuscular Centro Mixto Universidad de Valencia-CSIC Nikhef National Institute for Subatomic Physics and VU University Amsterdam National Research Tomsk Polytechnic University AGH-University of Science and Technology faculty of Computer Science Electronics and Telecommunications University of Michigan Università di Siena Università di Padova Scuola Normale Superiore National Research Centre Kurchatov Institute Università degli Studi di Milano MSU-Iligan Institute of Technology (MSU-IIT) Università di firenze INfN Sezione di Roma La Sapienza Institut für Physik Universit?t Rostock INfN Sezione di Milano Departamento de fisica Universidad Nacional de Colombia Universit?t Bonn-Helmholtz-Institut für Strahlen und Kernphysik Hanoi University of Science Università di Pisa P.N. Lebedev Physical Institute Russian Academy of Science (LPI RAS) Università

The first search for the doubly heavy Ωbc0baryon and a search for the Ξbc0baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 *** baryons are reconstructed via their decays to ∧c+π-andΞc+π-.No significant excess is found for invariant masses between 6700 and 7300 MeV/c2,in a rapidity range from2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ωbc0andΞbc0production cross-section times the branching fraction to ∧c+π-（Ξc+π-） relative to that of the ∧b0（Ξb0） baryon,for different lifetime hypotheses,at 95% confidence *** upper limits range from 0.5×10-4to 2.5×10-4for theΩbc0→∧c+π-(Ξbc0→∧c+π-) decay,and from 1.4×10-3to 6.9×10-3for the Ωbc0→Ξc+π-(Ξbc0→Ξc+π-) decay,depending on the considered mass and lifetime of the Ωbc0(Ξbc0) baryon.

关键词： B physics quarkonium spectroscopy heavy quark production

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Nat Methods:利用CRISPR-Cas9组合筛选发现癌症弱点

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现代生物医学进展 2017年第17期17卷 I0001-I0001页

作者： John Paul Shen, Ana Bojorquez-gomez, Katherine Licon, Kristin Klepper, Daniel Pekin, Alex N Beckett, Kyle Salinas Sanchez, Jason f Kreisberg, Trey Ideker John Paul Shen, Trey Ideker, Prashant Mali John Paul Shen, Dongxin Zhao, Dan Du, Assen Roguev, Jason f Kreisberg, Nevan Krogan, Lei Qi, Trey Ideker, Prashant Mali Dongxin Zhao, Chih-Chung Kuo, Prashant Mali Roman Sasik, Amanda Birmingham, Aaron N Chang, Trey Ideker Jens Luebeck, Alex Thomas Alex Thomas, Chih-Chung Kuo, Nathan E Lewis Dan Du Assen Roguev, Nevan Krogan Nathan E Lewis Lei Qi Department of Medicine Division of Genetics University of California San Diego La Jolla California USA Moores UCSD Cancer Center La Jolla California USA The Cancer Cell Map Initiative (CCMI) La Jolla and San Francisco California USA Department of Bioengineering University of California San Diego La Jolla California USA Center for Computational Biology & Bioinformatics University of California San Diego La Jolla California USA Bioinformatics & Systems Biology Program University of California San Diego La Jolla California USA Novo Nordisk Center for Biosustainability at the University of California San Diego La Jolla California USA Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research Department of Cell and Tissue Biology University of California San Francisco San Francisco California USA Department of Cellular and Molecular Pharmacology University of California San Francisco San Francisco California USA Department of Pediatrics University of California San Diego La Jolla California USA Department of Bioengineering Stanford University Stanford California USA.

导致癌症的基因突变也会削弱癌细胞，从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性（synthetic lethality）”，这是因为这些药物仅对发生突变的（或者说合成的）细胞是致命性的。在... 详细信息

导致癌症的基因突变也会削弱癌细胞，从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性（synthetic lethality）”，这是因为这些药物仅对发生突变的（或者说合成的）细胞是致命性的。在一项新的研究中。来自美国加州大学圣地亚哥分校、加州大学旧金山分校、斯坦福大学和癌细胞图谱项目（Cancer Cell Map Initiative）的研究人员开发出一种新的方法来寻找合成致死性的基因组合。

关键词：组合筛选癌症美国加州大学利用基因突变斯坦福大学癌细胞正常细胞

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