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Incidence of coronary artery disease before valvular surgery in isolated severe aortic stenosis

Chinese Medical Journal 2014年第22期127卷 3963-3969页

作者： eun jeong Cho Sung-Ji Park Sung-A chang Dong Seop jeong Sang-Chol Lee Seung Woo Park Pyo Won Park Division of Cardiology Department of Internal MedicineCardiovascular Imaging Center Cardiac and Vascular Center Samsung Medical CenterSungkyunkwan University School of Medicine Seoul Korea Department of Thorax Surgery Samsung Medical CenterSungkyunkwan University School of Medicine Seoul Korea

Background Angina pectoris has been recognized as one of the principal symptoms of aortic valve stenosis （AS）,even in patients without significant coronary artery disease （CAD）.However,the incidence of angina pectoris and related CAD in such patients is *** is continuing debate as to whether coronary angiography is necessary before aortic valve replacement （AVR） in patients with severe *** purpose of this study was to evaluate the incidence and predictors of CAD in patients with severe AS in a Korean *** Data from all consecutive patients with severe AS undergoing AVR at a major tertiary cardiac and vascular center in Korea were entered in a prospective registry beginning in *** and echocardiographic follow-up data were recorded into the database *** CAD was defined as one or more major coronary arteries having an estimated narrowing of ≥70％ and left main coronary arteries having an estimated narrowing of ≥50％ on coronary *** excluded patients with multiple valve disease,significant aortic regurgitation,or prior CAD or valve *** Totally 574 patients with severe AS （mean age,（65.9±9.6） years） were enrolled in this *** CAD was found in 61 patients （10.6％）.Factors associated with increased likelihood of CAD were age,hypertension,diabetes mellitus,chronic renal failure,carotid disease,and aorta *** Logistic regression analysis,the independent predictor of the presence of CAD was age （P=0.011）.The incidence of CAD increased significantly at 69.2 years of *** two risk factors for cardiovascular disease was the most useful cutoff to predict whether a patient was going to have significant *** There was a low incidence of significant CAD in a population of Korean patients with severe ***,coronary angiography before AVR will be considered in patients with multiple risk factors for cardiovascular disease or in patients more than 69 years of

关键词： severe aortic stenosis coronary artery disease aortic valve replacement

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An Efficient Viewport-Dependent 360 VR System Based on Adaptive Tiled Streaming

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Computers, Materials & Continua 2021年第3期66卷 2627-2643页

作者： Tuan Thanh Le Jong-Beom jeong Sang Soon Lee Jaehyoun Kim eun-Seok Ryu Department of Computer Engineering Gachon UniversitySeongnam13120Korea Department of Computer Education Sungkyunkwan UniversitySeoul03063Korea

Recent advances in 360 video streaming technologies have enhanced the immersive experience of video streaming ***,there is immense potential for the application of 360 video encoding formats to achieve highly immersive virtual reality(VR)***,360 video streaming requires considerable bandwidth,and its performance depends on several ***,the optimization of 360 video bitstreams according to viewport texture is ***,we propose an adaptive solution for VR systems using viewport-dependent tiled 360 video *** increase the degrees of freedom of users,the moving picture experts group(MPEG)recently defined three degrees plus of freedom(3DoF+)and six degrees of freedom(6DoF)to support free user movement within camera-captured *** proposed method supports 6DoF to allow users to move their heads ***,we propose viewport-dependent tiled 360 video streaming based on users’head *** proposed system generates an adaptive bitstream using tile sets that are selected according to a parameter set of user’s viewport *** extracted bitstream is then transmitted to the user’s *** decoding,the user’s viewport is generated and rendered on VR head-mounted display(HMD).Furthermore,we introduce certain approaches to reduce the motion-to-photon *** experimental results demonstrated that,in contrast with non-tiled streaming,the proposed method achieved high-performance 360 video streaming for VR systems,with a 25.89%BD-rate saving for Y-PSNR and 61.16%for decoding time.

关键词： Virtual reality 360 video MPEGimmersive 6DoF MCTS viewportdependent

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Prognostic role of plasma level of angiopoietin-1,angiopoietin-2,and vascular endothelial growth factor in hepatocellular carcinoma

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World Journal of Gastroenterology 2021年第27期27卷 4453-4467页

作者： Gwang Hyeon Choi eun Sun Jang Jin-Wook Kim Sook-Hyang jeong Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea

BACKGROUND Most hepatocellular carcinomas(HCCs)are hypervascular,with characteristic features of hepatic arterial supply to the *** factors involved in tumor angiogenesis include angiopoietin-1(Ang-1),angiopoietin-2(Ang-2),and vascular endothelial growth factor(VEGF).AIM To investigate the profiles of plasma levels of angiogenesis markers in patients with HCC and evaluate their roles in predicting overall survival(OS)and progression-free survival(PFS).METHODS Plasma samples from 240 prospectively enrolled HCC patients in the very early to advanced stages were used to measure the levels of Ang-1,Ang-2,and *** associations with clinical characteristics,OS,and PFS were *** The median plasma levels of Ang-1,Ang-2,and VEGF were 3216 pg/mL,1684 pg/mL,and 26.5 pg/mL,*** plasma level of Ang-2 showed a significant increase from early stage[Barcelona clinic liver cancer(BCLC)A]to intermediate(BCLC B)and advanced stage HCC(BCLC C/D),whereas Ang-1,VEGF,and alpha-fetoprotein(AFP)levels in the plasma did not show any such *** analysis,propensity score-matched analysis,and timedependent receiver operating curve analysis revealed that Ang-2 levels had the highest predictive power for OS and *** Ang-1 nor VEGF was significantly associated with OS or *** neutrophil-to-lymphocyte ratio was an independent factor for OS and *** The plasma levels of Ang-2 correlated with liver function,tumor stage,and tumor invasiveness,showing better performance in predicting OS and PFS than AFP,Ang-1,or VEGF.

关键词： Hepatocellular carcinoma Angiogenesis Biomarker Prognosis Survival

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Potential anti-tubercular agents:Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones

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Chinese Chemical Letters 2015年第5期26卷 567-571页

作者： Ayyakannu Arumugam Napoleon Fazlur-Rahman Nawaz Khan Euh Duck jeong eun Hyuk Chung Organic and Medicinal Chemistry Research Laboratory Organic Chemistry DivisionSchool of Advanced SciencesVIT-University Korea Basic Science Institute Busan Center

A series of indazol-2-yl（pyridin-4-yl）methanones, 4 were acquired from 2,6-bisbenzylidene cyclohex- anones, 3 and anti-tubercular drug （isoniazid）, and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs （streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL）.

关键词： Benzylidene cyclohexanones Hexahydro-3-phenyl indazol-2-yl (pyridin- 4-yl)methanones lsoniazid Anti-tubercular activity

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Serum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean men

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Asian Journal of Andrology 2008年第2期10卷 207-213页

作者： Sung Kyu Hong Byung Kyu Hart Jae Seung jeong Seong Jin jeong Ki Hyuk Moon Seok Soo Byun Sang eun Lee Department of Urology Seoul National University Bundang Hospital Seongnam 463-707 Korea

瞄准：为了调查浆液的关系，睾丸激素，像胰岛素的生长因素(IGF )-1 和 IGF 有约束力的蛋白质(IGFBP )-3 在收到了激进的制动火箭的朝鲜的人与前列腺癌症的已知的预示的参数与前列腺癌症风险并且也铺平为临床上局部性的前列腺癌症的阴... 详细信息

瞄准：为了调查浆液的关系，睾丸激素，像胰岛素的生长因素(IGF )-1 和 IGF 有约束力的蛋白质(IGFBP )-3 在收到了激进的制动火箭的朝鲜的人与前列腺癌症的已知的预示的参数与前列腺癌症风险并且也铺平为临床上局部性的前列腺癌症的阴毛的前列腺切除术(RRP ) 。方法：全部的睾丸激素，免费睾丸激素， IGF-1 和 IGFBP-3 的浆液层次在随后收到了前列腺活体检视的 592 个病人被决定。结果在最后为前列腺癌症收到了 RRP 的病人之间被比较(n= 159 ) 并且没从活体检视与前列腺癌症被诊断的那些(控制组， n= 433 ) 。在前列腺癌症之中仅仅病人，神经质的层次获得了的浆液在与特定的抗原(PSA ) ，病理学的 T 阶段和病理学的格利森获得的浆液前列腺的关系被分析。结果：前列腺癌症病人和控制组没越过不同年龄组关于全部的睾丸激素，免费睾丸激素， IGF-1 和 IGFBP-3 的浆液层次表明重要差别。在癌症之中仅仅病人，没有重要协会与病理学的 T 舞台，病理学的格利森分数和外科手术前的 PSA 为全部的睾丸激素，免费睾丸激素， IGF-1 和 IGFBP-3 层次的浆液层次被观察。结论：我们的数据显示与 IGFBP-3 层次一起的浆液睾丸激素和 IGF-1 的简单数量化离子可能不在朝鲜的人在临床上局部性的前列腺癌症的诊断提供有用临床的信息。另外，我们的结果建议睾丸激素， IGF-1 和 IGFBP-3 的浆液层次可能显著地没在朝鲜的人与临床上局部性的前列腺癌症的已知的预示的因素被联系。

关键词：前列腺炎前列腺癌睾丸激素胰岛素

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An Efficient and Spam-Robust Proximity Measure Between Communication Entities

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Journal of Computer Science & Technology 2013年第2期28卷 394-400页

作者： Joo Hyuk Jeon Jihwan Song jeong eun Kwon Yoon Joon Lee Man Ho Park Myoung Ho Kim Department of Computer Science Korea Advanced Institute of Science and Technology Biz Solution Team SK Telecom Information Technology R&D Center Mobile Communication Convergence Research Team Electronics and Telecommunications Research Institute

Electronic communication service providers are obliged to retain communication data for a certain amount of time by their local laws. The retained communication data or the communication logs are used in various applications such as crime detection, viral marketing, analytical study, and so on. Many of these applications rely on effective techniques for analyzing communication logs. In this paper, we focus on measuring the proximity between two communication entities, which is a fundamental and important step toward further analysis of communication logs, and propose a new proximity measure called ESP （Efficient and Spam-Robust Proximity measure）. Our proposed measure considers only the （graph- theoretically） shortest paths between two entities and gives small values to those between spam-like entities and others. Thus, it is not only computationally efficient but also spam-robust. By conducting several experiments on real and synthetic datasets, we show that our proposed proximity measure is more accurate, computationally efficient and spam-robust than the existing measures in most cases.

关键词： proximity closeness spam electronic communication

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Conservation and Diversification of the SHR-SCR- SCL23 Regulatory Network in the Development of the Functional Endodermis in Arabidopsis Shoots

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Molecular Plant 2016年第8期9卷 1197-1209页

作者： eun Kyung Yoon Souvik Dhar Mi-Hyun Lee Jae Hyo Song Shin Ae Lee Gyuree Kim Sejeong Jang Ji Won Choi jeong-eun Choe jeong Hoe Kim Myeong Min Lee Jun Lim Department of Systems Biotechnology Konkuk University Seoul 05029 Korea Department of Systems Biology Yonsei University Seoul 03722 Korea Department of Biology Kyungpook National University Daegu 41566 Korea 4TheSe tlRors cotribCited equally/to ttats article Present address: Department of Agricultural Biotechnology National Institute of Agricultural Sciences Jeonju 54874 Korea Present address: Department of Agricultural Biology National Institute of Agricultural Sciences Wanju 55365 Korea

Development of the functional endodermis of Arabidopsis thaliana roots is controlled, in part, by GRAS transcription factors, namely SHORT-ROOT （SHR）, SCARECROW （SCR）, and SCARECROW-LIKE 23 （SCL23）. Recently, it has been shown that the SHR-SCR-SCL23 regulatory module is also essential for spec- ification of the endodermis （known as the bundle sheath） in leaves. Nevertheless, compared with what is known about the role of the SHR-SCR-SCL23 regulatory network in roots, the molecular interactions of SHR, SCR, and SCL23 are much less understood in shoots. Here, we show that SHR forms protein com- plexes with SCL23 to regulate transcription of SCL23 in shoots, similar to the regulation mode of SCR expression. Our results indicate that SHR acts as master regulator to directly activate the expression of SCR and SCL23. In the SHR-SCR-SCL23 network, we found a previously uncharacterized negative feed- back loop whereby SCL23 modulates SHR levels. Through molecular, genetic, physiological, and morpho- logical analyses, we also reveal that the SHR-SCR-SCL23 module plays a key role in the formation of the endodermis （known as the starch sheath） in hypocotyls. Taken together, our results provide new insights into the regulatory role of the SHR-SCR-SCL23 network in the endodermis development in both roots and shoots.

关键词： endodermis gene regulatory network SHORT-ROOT SCARECROW SCARECROW-LIKE 23,transcription factor

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Foldable and washable textile-based OLEDs with a multi-functional near-room-temperature encapsulation layer for smart e-textiles

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npj Flexible Electronics 2021年第1期5卷 123-131页

作者： So Yeong jeong Hye Rin Shim Yunha Na Ki Suk Kang Yongmin Jeon Seungyeop Choi eun Gyo jeong Yong Cheon Park Ha-eun Cho Junwoo Lee jeong Hyun Kwon Sung Gap Im Kyung Cheol Choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Clothing and Textiles Chonnam National UniversityGwangjuRepublic of Korea Department of Display and Semiconductor Engineering Sun Moon UniversityAsanRepublic of Korea Department of Chemical and Biomolecular Engineering and KI for the NanoCentury Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea.

Wearable electronic devices are being developed because of their wide potential applications and user *** them,wearable organic light emitting diodes(OLEDs)play an important role in visualizing the data signal processed in wearable electronics to *** this study,textile-based OLEDs were fabricated and their practical utility was *** textilebased OLEDs exhibited a stable operating lifetime under ambient conditions,enough mechanical durability to endure the deformation by the movement of humans,and washability for maintaining its optoelectronic properties even in water condition such as rain,sweat,or *** this study,the main technology used to realize this textile-based OLED was multi-functional nearroom-temperature *** outstanding impermeability of TiO_(2)film deposited at near-room-temperature was *** internal residual stress in the encapsulation layer was controlled,and the device was capped by highly crosslinked hydrophobic polymer film,providing a highly impermeable,mechanically flexible,and waterproof encapsulation.

关键词： OLEDs layer film

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Effect of expanding nanocellulose sponge on nasal mucosal defects in an animal model

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Regenerative Biomaterials 2020年第1期7卷 47-52页

作者： JiWon Kim Kyungbae Woo jeong Mi Kim Mi eun Choi Young-Mo Kim Su-Geun Yang Bong Sup Shim jeong-Seok Choi Department of Otorhinolaryngology Inha UniversityCollege of Medicine27 Inhang-roJung-guIncheon 22332Republic of Korea Department of Chemical Engineering Inha University100 InharoMichuholguIncheon 22212Republic of Korea Department of New Drug Development Inha UniversityCollege of MedicineB-308Chungsuk Bldg.366Seohae-DaeroJung-GuIncheon 22332Republic of Korea

Nanocellulose has emerged for a wide range of applications in biomedical engineering because of its water absorption capacity,appropriate *** investigated the hemostatic and regenerative abilities of an expanding polyvinyl alcohol(PVA)-nanocellulose sponge on nasal mucosal defects.A 3 mm-diameter nasal defect was made in experimental *** were divided into four groups with control,vaseline,PVA and PVA-nanocellulose packing *** the defect was created,bleeding times and amounts were *** materials were removed on experimental day(ED)*** ED 3,7 and 14,histological analysis and immunohistochemical study for neutrophils were *** cells were counted and epithelial thicknesses were *** amounts and times in the vaseline packing group were smaller than in the PVA ***-nanocellulose group showed less neutrophils than in the other groups on ED *** epithelium thickness in the PVA-nanocellulose group was significantly smaller than in the control group at ED 7,but at ED 14,there was no significant intergroup *** group had a significant lower inflammatory cell count than the control group on ED ***-nanocellulose sponge applied to nasal mucosal defects can significantly enhance mucosal regeneration during early wound healing.

关键词： polyvinyl alcohol nasal mucosa nanocellulose

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Effect of Asiasari radix on osteoblastic differentiation of stem cells derived from gingiva

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Journal of Traditional Chinese Medicine 2016年第6期36卷 756-759页

作者： Su-Hyeon jeong Ji-eun Lee Seong-Ho Jin Youngkyung Ko Jun-Beom Park Department of Rehabilitation Medicine of Korean Medicine Chungju Hospital of Korean MedicineCollege of Korean Medicine Semyung University Development of Periodontics College of MedicineThe Catholic University of Korea

OBJECTIVE: To examine the dose-dependent impact of Asiasari Radix(A. radix) on the cell viability,differentiation and mineralization of stem cells derived from ***: Stem cells that were derived from gingiva were grown in the presence of A. radix at final concentrations that ranged from 0.001 to 10 μg/m L. The morphology of the cells was viewed under an inverted microscope and the analysis of cell proliferation was performed by using Cell Counting Kit-8(CCK-8) on day 1. The alkaline phosphatase activity test was used to assess differentiation and Alizarin red S staining was used to assess mineralization of treated ***: The control group showed spindleshaped, fibroblast-like morphology and the shapesof the cells in 0.001, 0.01, 0.1, 1 and 10 μg/mL of *** were similar to that of the control group at day 1. The cultures growing in the presence of0.001 μg/m L of A. radix at day 1 showed an increase in the CCK-8 value(P 0.05). Mineralized extracellular deposits were observed after Alizarin Red S staining and the cultures grown in the presence of 0.001 μg/m L of A. radix showed the highest value for quantitative results for bound dye(P < 0.05).CONCLUSION: Within the limits of this study, A. radix influenced the proliferation of stem cells derived from the gingiva and low concentrations of *** might enhance osteogenic differentiation of the stem cells.

关键词：成骨细胞分化胚胎干细胞牙龈细辛碱性磷酸酶活性 CCK-8 细胞增殖细胞形态

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