Effect of expanding nanocellulose sponge on nasal mucosal defects in an animal model
作者机构：Department of OtorhinolaryngologyInha UniversityCollege of Medicine27 Inhang-roJung-guIncheon 22332Republic of Korea Department of Chemical EngineeringInha University100 InharoMichuholguIncheon 22212Republic of Korea Department of New Drug DevelopmentInha UniversityCollege of MedicineB-308Chungsuk Bldg.366Seohae-DaeroJung-GuIncheon 22332Republic of Korea
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2020年第7卷第1期
页 面：47-52页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：This research was supported by the Basic Science Research Program,the Medical Research Center(MRC)through the National Research Foundation of Korea(NRF)by the Korean government(MOE and MSIT)(NRF-2016R1D1A1A02937416,NRF-2017R1A6A3A11027865,NRF-2017R1D1A1B03030819,2018R1A6A1A03025523 and NRF-2014R1A5A2009392) also supported by Civil Military Co-Technology Development Program(16-CM-SS-07)from Civil Military Technology Cooperation Center.B.S.S.acknowledges the funding supports by NRF-2017R1A2B4012736 and NRF-2018K1A3A1A32055149
主 题：polyvinyl alcohol nasal mucosa nanocellulose
摘 要：Nanocellulose has emerged for a wide range of applications in biomedical engineering because of its water absorption capacity,appropriate *** investigated the hemostatic and regenerative abilities of an expanding polyvinyl alcohol(PVA)-nanocellulose sponge on nasal mucosal defects.A 3 mm-diameter nasal defect was made in experimental *** were divided into four groups with control,vaseline,PVA and PVA-nanocellulose packing *** the defect was created,bleeding times and amounts were *** materials were removed on experimental day(ED)*** ED 3,7 and 14,histological analysis and immunohistochemical study for neutrophils were *** cells were counted and epithelial thicknesses were *** amounts and times in the vaseline packing group were smaller than in the PVA ***-nanocellulose group showed less neutrophils than in the other groups on ED *** epithelium thickness in the PVA-nanocellulose group was significantly smaller than in the control group at ED 7,but at ED 14,there was no significant intergroup *** group had a significant lower inflammatory cell count than the control group on ED ***-nanocellulose sponge applied to nasal mucosal defects can significantly enhance mucosal regeneration during early wound healing.
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