Potential anti-tubercular agents:Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones

作     者：Ayyakannu Arumugam Napoleon Fazlur-Rahman Nawaz Khan Euh Duck Jeong Eun Hyuk Chung 

作者机构：Organic and Medicinal Chemistry Research LaboratoryOrganic Chemistry DivisionSchool of Advanced SciencesVIT-University Korea Basic Science InstituteBusan Center 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2015年第26卷第5期

页      面：567-571页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：VIT University for providing us with research funding and laboratory facilities Maratha Mandal Dental College,Belgaum for biological screening support 

主　　题：Benzylidene cyclohexanones Hexahydro 3 phenyl indazol 2 yl (pyridin  4 yl)methanones lsoniazid Anti tubercular activity 

摘      要：A series of indazol-2-yl（pyridin-4-yl）methanones, 4 were acquired from 2,6-bisbenzylidene cyclohex- anones, 3 and anti-tubercular drug （isoniazid）, and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs （streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL）.