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Prevalence,phenotype and medication for the pediatric inflammatory bowel disease population of a state in southeastern Brazil

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World Journal of Clinical Pediatrics 2022年第4期11卷 341-350页

作者： Adalberta Lima martins Renata de sáBrito Fróes Maria da Penha Zago-Gomes Pharmaceutical Assistance Health Department of Espírito SantoVitoria 29052-210Espírito SantoBrazil Department of Gastroenterology GastromedRio de Janeiro 22640-100Rio de JaneiroBrazil Departament of Medical Clinical Hospital Universitário Cassiano Antonio MoraesVitoria 29042-755Espírito SantoBrazil

BACKGROUND Inflammatory bowel disease(IBD)can lead to social and economic impacts *** Brazil,where its adult prevalence is increasing,the epidemiology of the pediatric population is not well known,although there is a documented increase in pediatric IBD incidence *** has continental dimensions,and Espírito santo is a state of southeastern Brazil,the region with the highest demographic densities and is the economically most important in the *** To assess the prevalence,incidence,phenotype and medications in a southeastern Brazilian pediatric *** Data were retrieved from the Public Medication-Dispensing system of the Department of Health in Espírito santo state from documentation required to have access to highly expensive medication from August 1,2012 to July 31,*** were 1048 registered patients with IBD of all ages,and of these patients,the cases≤17 years were *** data were obtained through the analysis of administrative requests for these medications and included medical reports,endoscopy exams,histopathology and imaging tests,which followed the Clinical Protocols and Therapeutic Guidelines of the Brazilian *** confirmed cases of IBD were included in the *** There were 55 pediatric patients/1048 registered patients(5.34%),with Crohn's disease(CD)representing 30/55(55%),ulcerative colitis(UC)24/55(43.6%)and 1 unclassified IBD,a significant difference from adult patients(P=0.004).The prevalence of IBD in pediatric patients was 5.02 cases/100.000 inhabitants;the incidence in 2014 was 1.36 cases/100.000 *** mean age at diagnosis was 12.2 years(±4.2).There were 7 children diagnosed up to 6 years old,7 between 7 to 10 years old and 41 between 11 and≤17 years *** was no difference in the distribution of UC and CD between these age categories(P=0.743).There was no difference in gender distribution in relation to *** and adolescents with UC had a predominance of

关键词： Inflammatory bowel disease Pediatric Prevalence Phenotype Brazil

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Transpiration and growth responses by Eucalyptus species to progressive soil drying

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Journal of Forestry Research 2022年第5期33卷 1529-1543页

作者： Marcel Carvalho Abreu Alvaro Augusto Vieira soares Cleverson Henrique de Freitas Fabrina Bolzan martins Department of Environment science Forest InstituteFederal Rural University of Rio de JaneiroSeropédicaRio de Janeiro 23890-000Brazil Institute of Agricultural sciences Federal University of UberlândiaMonte CarmeloMinas Gerais 38405-302Brazil “Luiz de Queiroz”College of Agriculture University of São PauloPiracicabaSão Paulo 13418-900Brazil Natural Resources Institute Federal University of ItajubáItajubáMinas Gerais 37500-903Brazil

The regulation of plant transpiration is a key factor affecting transpiration efficiency, growth and adaptation of Eucalyptus species to limited water availability in tropical and subtropical environments. However, few studies have related this trait to the performance of Eucalyptus seedlings and none have investigated the influence of vapor pressure deficit (VPD) on transpiration rates and growth. In this study, the transpiration and growth responses of seedlings of Eucalyptus urophylla (s.T. Blake) and Eucalyptus cloeziana (F. Muell.) to progressive soil water deficits were evaluated under semi-controlled conditions using the fraction of transpirable soil water (FTsW) method. In addition, the influence of VPD on seedling transpiration, development and growth was also investigated. The FTsW threshold ranged from 0.40 to 0.99 for the transpiration rate and from 0.32 to 0.97 for the development and growth variables. Little or no changes in the FTsW threshold were detected in response to changes in atmospheric VPD. Both Eucalyptus species presented a conservation strategy under drought stress. In addition, water-conserving mechanisms during the seedling phase were related to rapid stomatal closure, reduced leaf area, and number of leaves.

关键词： soil water deficit Fraction of transpirable soil water Transpiration seedling growth Vapor pressure deficit

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Energy-band engineering by 2D MXene doping for high-performance homojunction transistors and logic circuits

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Journal of Materials science & Technology 2023年第28期159卷 41-51页

作者： Leini Wang Gang He Wenhao Wang Xiaofen Xu shanshan Jiang Elvira Fortunato Rodrigo martins school of Materials science and Engineering Anhui UniversityHefei 230601China school of Integration Circuits Anhui UniversityHefei 230601China Department of Materials science/CENIMAT-I3N Faculty of Sciences and TechnologyNew University of Lisbon and CEMOP-UNINOVA Campus de Caparica 2829-516 Caparic1Portugal

The homojunction based on Ti_(3)C_(2)T_(x) MXene-doped In_(2)O_(3) and indium oxide as the channel layer is real-ized in high-performance metal oxide thin film transistors(TFTs).Doping of MXene into In_(2)O_(3) results in n-type semiconductor behavior,realizing tunable work function of In_(2)O_(3) from 5.11 to 4.79 eV as MXene content increases from 0 to 2 wt.%.MXene-doped In_(2)O_(3)-based homojunction TFT presents optimal per-formance with electron mobilities of greater than 27.10 cm^(2)/(V s)at 240°C,far exceeding the maximum mobility of 3.91 cm^(2)/(V s)for single-layer In_(2)O_(3)*** improved performance originates from boosting of a two-dimensional electron gas(2DEG)formed at carefully engineered In_(2)O_(3)/MXene-doped In_(2)O_(3)ox-ide homojunction ***,the transformation in conduction mechanism leads to better stability of MXene-doped In_(2)O_(3) homojunction devices compared to undoped bilayer In_(2)O_(3).Low-frequency noise further illustrates that doping MXene into In_(2)O_(3) helps to reduce the device trap density,demonstrating excellent electrical performance.A resistor-loaded unipolar inverter based on In_(2)O_(3)/0.5%MXene-In_(2)O_(3)TFT has demonstrated full swing characteristics and a high gain of *** effective doping of MXene into constructed homojunction TFTs not only contributes to improved stability,but also provides an ef-fective strategy for designing novel homojunction TFTs for low-cost oxide-based electronics.

关键词： MXene-doped In_(2)O_(3) Homojunction 2D electron gases Thin film transistor Low frequency noise

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Evolution of the 3.65-2.58 Ga Mairi Gneiss Complex,Brazil:Implications for growth of the continental crust in the são Francisco Craton

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Geoscience Frontiers 2022年第5期13卷 110-128页

作者： Igor de Camargo Moreira Elson Paiva Oliveira Daniel Francisco martins de sousa Institute of Geosciences University of Campinas(UNICAMP)CampinasSPBrazil

The composition and formation of the Earth’s primitive continental crust and mantle differentiation are key issues to understand and reconstruct the geodynamic terrestrial evolution,especially during the ***,the scarcity of exposure to these rocks,the complexity of lithological relationships,and the high degree of superimposed deformation,especially with long-lived magmatism,make it difficult to study ancient *** this complexity,exposures of the Archean Mairi Gneiss Complex basement unit in the são Francisco Craton offer important information about the evolution of south America’s primitive ***,here we present field relationships,LA-ICP-sFMs zircon U-Pb ages,and LA-ICP-MCMs Lu-Hf isotope data for the recently identified Eoarchean to Neoarchean gneisses of the Mairi *** Complex is composed of massive and banded gneisses with mafic members ranging from dioritic to tonalitic,and felsic members ranging from TTG(Tonalite-Trondhjemite-Granodiorite)to granitic *** new data point to several magmatic episodes in the formation of the Mairi Gneiss Complex:Eoarchean(ca.3.65–3.60 Ga),early Paleoarchean(ca.3.55–3.52 Ga),middle-late Paleoarchean(ca.3.49–3.33 Ga)and Neoarchean(ca.2.74–2.58 Ga),with no records of Mesoarchean ***-Hf data unveiled a progressive evolution of mantle differentiation and crustal recycling over *** the Eoarchean,rocks are probably formed by the interaction between the pre-existing crust and juvenile contribution from chondritic to weakly depleted mantle sources,whereas mantle depletion played a role in the Paleoarchean,followed by greater differentiation of the crust with thickening and recycling in the middle–late Paleoarchean.A different stage of crustal growth and recycling dominated the Neoarchean,probably owing to the thickening of the continental crust by collision,continental arc growth,and mantle differentiation.

关键词： são Francisco Craton Mairi Gneiss Complex Primitive continental crust Zircon U-Pb dating Lu-Hf isotope geochemistry

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sCIENCE OF WINNING sOCCER:EMERGENT PATTERN-FORMING DYNAMICs IN AssOCIATION FOOTBALL

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Journal of systems science & Complexity 2013年第1期26卷 73-84页

作者： VILAR Luís ARAUJO duarte DAVIDs Keith BAR-YAM Yaneer Faculty of Physical Education and sports Lusofona University of Humanities and Technologies Faculty of Human Kinetics Technical University of Lisbon spertLab CIPERFaculty of Human KineticsTechnical University of Lisbon school of Human Movement studies Queensland University of Technologies New England Complex systems Institute

Quantitative analysis is increasingly being used in team sports to better understand performance in these stylized,delineated,complex social ***,the authors provide a first step toward understanding the pattern-forming dynamics that emerge from collective offensive and defensive behavior in team *** authors propose a novel method of analysis that captures how teams occupy sub-areas of the field as the ball changes *** authors use this method to analyze a game of association football(soccer) based upon a hypothesis that local player numerical dominance is key to defensive stability and offensive *** authors find that the teams consistently allocated more players than their opponents in sub-areas of play closer to their own *** is consistent with a predominantly defensive strategy intended to prevent yielding even a single *** authors also find differences between the two teams' strategies:while both adopted the same distribution of defensive,midfield,and attacking players(a 4:3:3 system of play),one team was significantly more effective in maintaining both defensive and offensive numerical dominance for defensive stability and offensive *** team indeed won the match with an advantage of one goal(2 to 1) but the analysis shows the advantage in play was more pervasive than the single goal victory would *** proposed focus on the local dynamics of team collective behavior is distinct from the traditional focus on individual player *** supports a broader view in which specific player abilities contribute within the context of the dynamics of multiplayer team coordination and coaching *** applying this complex system analysis to association football,the authors can understand how players' and teams' strategies result in successful and unsuccessful relationships between teammates and opponents in the area of play.

关键词：足球形成动态图案科学社会系统定量分析动态范围复杂系统

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Biomarkers of hypoxic-ischemic encephalopathy:a systematic review

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World Journal of Pediatrics 2023年第6期19卷 505-548页

作者： Ines Caramelo Margarida Coelho Miguel Rosado Carla M.P.Cardoso Alexandra Dinis Carlos B.duarte Mario Graos Bruno Manadas CNC-Center for Neuroscience and Cell Biology University of Coimbra3004‑504 CoimbraPortugal PhD Programme in Experimental Biology and Biomedicine Institute for Interdisciplinary Research(IIIUC)University of CoimbraCasa Costa Alemão3030‑789 CoimbraPortugal Chemistry Department Faculty of Sciences and TechnologyUniversity of Coimbra3004‑535 CoimbraPortugal stemlab sA 3060‑197 CantanhedePortugal Pediatric Intensive Care Unit Hospital PediátricoCentro Hospitalar E Universitário de Coimbra3000‑075 CoimbraPortugal Department of Life sciences University of Coimbra3001‑401 CoimbraPortugal Biocant Technology Transfer Association3060‑197 CantanhedePortugal Institute for Interdisciplinary Research University of Coimbra(IIIUC)3030‑789 CoimbraPortugal

Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement ***,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(PROsPERO ID:CRD42021272610).Data sources searches were performed in PubMed,Web of science,and science Direct databases until November *** original papers analyzing samples from newborns>36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were *** was assessed by the Newcastle–Ottawa *** search and data extraction were verified by two authors *** From 373 papers,30 met the inclusion *** from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and s100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal *** addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic ***,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to *** Neuron-specific enolase and s100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy ***,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice.

关键词： Biomarker Hypoxic-ischemic encephalopathy Neonatal brain injury Newborn Neuron-specific enolase s100-calcium-binding protein-B

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Acute kidney injury and electrolyte disorders in COVID-19

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World Journal of Virology 2022年第5期11卷 283-292页

作者： Gabriel martins Nogueira Noel Lucas Oliveira Rodrigues silva Ana Flávia Moura Marcelo Augusto duarte silveira JoséA Moura-Neto Department of Medicine Bahiana School of Medicine and Public HealthSalvador 40290-000BahiaBrazil Department of Nephrology D’Or Institute for Research and EducationHospital São RafaelSalvador 41253900BahiaBrazil

Acute kidney injury(AKI)and electrolyte disorders are important complications of hospitalized coronavirus disease 2019(COVID-19)*** is thought to occur due to multiple pathophysiological mechanisms,such as multiple organ dysfunction(mainly cardiac and respiratory),direct viral entry in the renal tubules,and cytokine release *** is present in approximately one in every ten hospitalized COVID-19 *** incidence rates of AKI increase in patients who are admitted to the intensive care unit(ICU),with levels higher than 50%.Additionally,renal replacement therapy(RRT)is used in 7%of all AKI cases,but in nearly 20%of patients admitted to an ***-19 patients with AKI are considered moderate-to-severe cases and are managed with multiple interdisciplinary *** acts as a risk factor for mortality in severe acute respiratory syndrome coronavirus 2 infection,especially when RRT is *** disorders are also common manifestations in hospitalized COVID-19 patients,mainly hyponatremia,hypokalemia,and *** occurs due to a combination of syndrome of inappropriate secretion of antidiuretic hormone and gastrointestinal fluid loss from vomiting and *** it comes to hypokalemia,its mechanism is not fully understood but may derive from hyperaldosteronism due to renin angiotensin aldosterone system overstimulation and gastrointestinal fluid loss as *** clinical features of hypokalemia in COVID-19 are similar to those in other *** is the most common electrolyte disorder in COVID-19 and seems to occur because of vitamin D deficiency and parathyroid *** is also highly associated with longer hospital and ICU stay.

关键词： COVID-19 sARs-CoV-2 Acute kidney injury Electrolyte disorders Renal dialysis

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Overcoming the limitations of 3D sensors with wide field of view metasurface-enhanced scanning lidar

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Advanced Photonics 2023年第4期5卷 51-65页

作者： Emil Marinov Renato Juliano martins Mohamed Aziz Ben Youssef Christina Kyrou Pierre-Marie Coulon Patrice Genevet Universite Cote d’Azur CNRSCRHEAValbonneFrance

Lidar, a technology at the heart of autonomous driving and robotic mobility, performs 3D imaging ofa complex scene by measuring the time of flight of returning light pulses. Many technological challenges,including enhancement of the observation field of view (FoV), acceleration of the imaging frame rate,improvement of the ambiguity range, reduction of fabrication cost, and component size, must besimultaneously addressed so that lidar technology reaches the performance needed to strongly impact theglobal market. We propose an innovative solution to address the problem of wide FoV and extendedunambiguous range using an acousto-optic modulator that rapidly scans a large-area metasurface *** further exploit a multiplexing illumination technique traditionally deployed in the context of telecommu-nication theory to extend the ambiguity range and to drastically improve the signal-to-noise ratio of themeasured signal. Compacting our metasurface-scanning lidar system to chip-scale dimension would opennew and exciting perspectives, eventually relevant to the autonomous vehicles and robotic industries.

关键词： light detection and ranging metasurfaces beam steering code division multiple access

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PM_(2.5) chemical composition and health risks by inhalation near a chemical complex

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Journal of Environmental sciences 2023年第2期124卷 860-874页

作者： Celia Alves Margarita Evtyugina Estela Vicente Ana Vicente Ismael Casotti Rienda Ana sanchez de la Campa Mario Tome Iola duarte Department of Environment Centre for Environmental and Marine Studies(CESAM)University of Aveiro3810-193 AveiroPortugal Associate Unit CsIC-University of Huelva“Atmospheric Pollution” Centre for Research in Sustainable Chemistry-CIQSOUniversity of HuelvaE21071 HuelvaSpain Department of Mining MechanicEnergetic and Construction EngineeringETSIUniversity of Huelva21071 HuelvaSpain PROMETHEUs School of Technology and Management(ESTG)Polytechnic Institute of Viana do Castelo4900-348 Viana do CasteloPortugal Department of Chemistry CICECO-Aveiro Institute of MaterialsUniversity of Aveiro3810-193 AveiroPortugal

Particulate matter(PM_(2.5))samples were collected in the vicinity of an industrial chemical pole and analysed for organic and elemental carbon(OC and EC),47 trace elements and around 150 organic *** average,OC and EC accounted for 25.2% and 11.4% of the PM_(2.5) mass,*** compounds comprised polycyclic aromatic hydrocarbons(PAHs),alkylated PAHs,anhydrosugars,phenolics,aromatic ketones,glycerol derivatives,aliphatic alcohols,sterols,and carboxyl groups,including aromatic,carboxylic and dicarboxylic *** factors>100 were obtained for Pb,Cd,Zn,Cu,sn,B,se,Bi,sb and Mo,showing the contribution of industrial emissions and nearby major *** component analysis revealed that vehicle,industrial and biomass burning emissions accounted for 66%,11% and 9%,respectively,of the total PM_(2.5)-bound *** of the detected organic constituents are likely associated with plasticiser ingredients and thermal stabilisers used in the manufacture of PVC and other plastics in the industrial *** products of both anthropogenic(e.g.,toluene)and biogenic(e.g.,isoprene and pinenes)precursors were also *** was estimated that biomass burning accounted for 13.8%of the PM_(2.5) concentrations and that secondary OC represented 37.6% of the total *** lifetime cancer risk from inhalation exposure to PM_(2.5)-bound PAHs was found to be negligible,but it exceeded the threshold of 10−6 for metal(loi)s,mainly due to Cr and As.

关键词： PM_(2.5) OC/EC Organic speciation Trace elements Cancer and non-cancer risks

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Atlantic Forest Hotspot: Why We should Consider Mature Forests a Conservation Priority in the são Paulo Metropolitan Region, southeastern Brazil

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Journal of Environmental Protection 2022年第1期13卷 69-83页

作者： Eduardo Hortal Pereira Barretto Eduardo Luís.martins Catharino sã o Paulo City Herbarium S&atilde o Paulo SP Brazil sã o Paulo Botanical Institute S&atilde o Paulo SP Brazil

The Atlantic Forest is among the 35 hotspots on the planet, and yet few floristic or structural studies have been conducted on mature forest fragments of that biome in Brazil. In view of this knowledge gap and of the need to further comprehend the importance of conserving mature forests, we surveyed the arboreal component of three little-altered forest remnants from the s?o Paulo metropolitan region (sPMR), southeastern Brazil, and compared our data with the one from other phytosociological studies performed in the region. Mature forests showed a different floristic composition from one of young forests. Overall, the former has a higher number and percentage of threatened and endemic species than the latter, and also a higher exclusivity of occurrence of threatened species. In areas up to twice as smaller, mature forests have 1.5 to 4.3 times more endemic species to the Atlantic Forest and up to 9 times more species threatened with extinction than young forests. These facts, along with the scarcity of remnants of mature forests, led us to consider such forests as hotspots within the Atlantic Forest hotspot in the sPMR, as well as to categorize them as of high relevance for conservation.

关键词： Threatened species Endemic species Primary Forest Tropical Forest Forest succession Biodiversity Phytosociology

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