Prevalence,phenotype and medication for the pediatric inflammatory bowel disease population of a state in Southeastern Brazil

作     者：Adalberta Lima Martins Renata de SáBrito Fróes Maria da Penha Zago-Gomes 

作者机构：Pharmaceutical AssistanceHealth Department of Espírito SantoVitoria 29052-210Espírito SantoBrazil Department of GastroenterologyGastromedRio de Janeiro 22640-100Rio de JaneiroBrazil Departament of Medical ClinicalHospital Universitário Cassiano Antonio MoraesVitoria 29042-755Espírito SantoBrazil 

出 版 物：《World Journal of Clinical Pediatrics》 (世界临床儿科杂志)

年 卷 期：2022年第11卷第4期

页      面：341-350页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：approved by the Ethics and Research Committee of the Nossa Senhora da Gloria Children’s Hospital(CAAE 19602813.8.0000.5069)after obtaining authorization from the State Office for Pharmaceutical Assistance.The term of clarification and consent was waived because the data used is secondary data 

主　　题：Inflammatory bowel disease Pediatric Prevalence Phenotype Brazil 

摘      要：BACKGROUND Inflammatory bowel disease(IBD)can lead to social and economic impacts *** Brazil,where its adult prevalence is increasing,the epidemiology of the pediatric population is not well known,although there is a documented increase in pediatric IBD incidence *** has continental dimensions,and Espírito Santo is a state of southeastern Brazil,the region with the highest demographic densities and is the economically most important in the *** To assess the prevalence,incidence,phenotype and medications in a Southeastern Brazilian pediatric *** Data were retrieved from the Public Medication-Dispensing System of the Department of Health in Espírito Santo state from documentation required to have access to highly expensive medication from August 1,2012 to July 31,*** were 1048 registered patients with IBD of all ages,and of these patients,the cases≤17 years were *** data were obtained through the analysis of administrative requests for these medications and included medical reports,endoscopy exams,histopathology and imaging tests,which followed the Clinical Protocols and Therapeutic Guidelines of the Brazilian *** confirmed cases of IBD were included in the *** There were 55 pediatric patients/1048 registered patients(5.34%),with Crohn s disease(CD)representing 30/55(55%),ulcerative colitis(UC)24/55(43.6%)and 1 unclassified IBD,a significant difference from adult patients(P=0.004).The prevalence of IBD in pediatric patients was 5.02 cases/100.000 inhabitants;the incidence in 2014 was 1.36 cases/100.000 *** mean age at diagnosis was 12.2 years(±4.2).There were 7 children diagnosed up to 6 years old,7 between 7 to 10 years old and 41 between 11 and≤17 years *** was no difference in the distribution of UC and CD between these age categories(P=0.743).There was no difference in gender distribution in relation to *** and adolescents with UC had a predominance of