Biomarkers of hypoxic-ischemic encephalopathy:a systematic review
作者机构：CNC-Center for Neuroscience and Cell BiologyUniversity of Coimbra3004‑504 CoimbraPortugal PhD Programme in Experimental Biology and BiomedicineInstitute for Interdisciplinary Research(IIIUC)University of CoimbraCasa Costa Alemão3030‑789 CoimbraPortugal Chemistry DepartmentFaculty of Sciences and TechnologyUniversity of Coimbra3004‑535 CoimbraPortugal Stemlab SA3060‑197 CantanhedePortugal Pediatric Intensive Care UnitHospital PediátricoCentro Hospitalar E Universitário de Coimbra3000‑075 CoimbraPortugal Department of Life SciencesUniversity of Coimbra3001‑401 CoimbraPortugal BiocantTechnology Transfer Association3060‑197 CantanhedePortugal Institute for Interdisciplinary ResearchUniversity of Coimbra(IIIUC)3030‑789 CoimbraPortugal
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2023年第19卷第6期
页 面：505-548页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
基 金：funding provided by FCT|FCCN(b-on) financed by the European Regional Development Fund(ERDF),through the COMPETE 2020—Operational Programme for Competitiveness and Internationalization and Portuguese national funds via FCT-Fundcao para a Ciencia e a Tecnologia,under projects POCI-01-0145-FEDER-029311,POCI-01-0247-FEDER-045311,UIDB/04539/2020 and UIDP/04539/2020 individual Ph.D.fellowships PD/BD/135178/2017(Margarida Coelho),SFRH/BD/143442/2019(Ines Caramelo),and 2020.07749.BD(Miguel Rosado)
主 题：Biomarker Hypoxic-ischemic encephalopathy Neonatal brain injury Newborn Neuron-specific enolase S100-calcium-binding protein-B
摘 要：Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early hours lack objective measurement ***,this systematic review aims to identify putative molecules that can be used in diagnosis in daily clinical practice(PROSPERO ID:CRD42021272610).Data sources Searches were performed in PubMed,Web of Science,and Science Direct databases until November *** original papers analyzing samples from newborns36 weeks that met at least two American College of Obstetricians and Gynecologists diagnostic criteria and/or imaging evidence of cerebral damage were *** was assessed by the Newcastle–Ottawa *** search and data extraction were verified by two authors *** From 373 papers,30 met the inclusion *** from samples collected in the first 72 hours were extracted,and increased serum levels of neuron-specific enolase and S100-calcium-binding protein-B were associated with a worse prognosis in newborns that suffered an episode of perinatal *** addition,the levels of glial fibrillary acidic protein,ubiquitin carboxyl terminal hydrolase isozyme-L1,glutamic pyruvic transaminase-2,lactate,and glucose were elevated in newborns diagnosed with hypoxic–ischemic ***,pathway analysis revealed insulin-like growth factor signaling and alanine,aspartate and glutamate metabolism to be involved in the early molecular response to *** Neuron-specific enolase and S100-calcium-binding protein-B are potential biomarkers,since they are correlated with an unfavorable outcome of hypoxic-ischemic encephalopathy ***,more studies are required to determine the sensitivity and specificity of this approach to be validated for clinical practice.
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