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Adalimumab in ulcerative colitis: Two cases of mucosal healing and clinical response at two years

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World Journal of Gastroenterology 2009年第30期15卷 3814-3816页

作者： Manuel Barreiro-de Acosta Aurelio Lorenzo Juan enrique Dominguez-Muoz department of Gastroenterology University Hospital of Santiago de CompostelaC/Choupanas/nE-15706-Santiago de CompostelaSpain

Infliximab (IFX) is currently the only biologic therapy used in the treatment of moderate-to-severe ulcerative colitis (UC). In the years to come, more biologic therapies will have a role in the management of moderate-to-severe UC. We report on two patients with steroid-dependent UC who, due to adverse reactions to IFX, have been under therapy with adalimumab for two years. Both patients received concomitant immunosuppressive treatment. Long term clinical remission and mucosal healing are described.

关键词： Adalimumab Ulcerative colitis Mucosalhealing Maintenance treatment

Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic-ischemic brain injury

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Neural Regeneration Research 2013年第8期8卷 731-744页

作者： Lara-Celador I. Goi-de-Cerio F. Antonia Alvarez enrique Hilario department of Cell Biology and Histology School of Medicine and DentistryUniversity of the Basque Country GAIKER Technology Centre Bizkaia Science and Technology Park

One of the most important causes of brain injury in the neonatal period is a perinatal hypoxicischemic *** devastating condition can lead to long-term neurological deficits or even *** hypoxic-ischemic brain injury,a variety of specific cellular mechanisms are set in motion,triggering cell damage and finally producing cell *** therapeutic treatments against this phenomenon are still unavailable because of complex molecular mechanisms underlying hypoxic-ischemic brain *** a thorough understanding of the mechanism underlying neural plasticity following hypoxic-ischemic brain injury,various neuroprotective therapies have been developed for alleviating brain injury and improving long-term *** them,the endocannabinoid system emerges as a natural system of *** endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury,acting as a natural *** aim of this review is to study the use of different therapies to induce long-term therapeutic effects after hypoxic-ischemic brain injury,and analyze the important role of the endocannabinoid system as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.

关键词： neural regeneration reviews perinatal hypoxia-ischemia brain injury brain plasticity,neuroprotective strategies cannabinoid system grants-supported paper photographs-containingpaper neuroregeneration

Caving performance through the integration of microseismic activity and numerical modeling at DOZ-PT Freeport,Indonesia

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International Journal of Minerals,Metallurgy and Materials 2009年第1期16卷 1-6页

作者： Rubio enrique Napitupulu Daulat Mining Engineering department Universidad de Chile Geotechnical Engineering department PT Freeport IndonesiaTembagapuraIndonesia

This article describes an undergoing research at PT Freeport, Indonesia, in which the main goal is to use the microseismic information recorded as a result of mining to analyze cave propagation and stress performance on the actual production and fixed infrastructure. At the moment, several numerical experiments have been conducted to correlate the mining activity with the microseismic events using the data collected during year 2005 and 2006. As a result of the preliminary analysis a micro- and a macrocracking envelop were proposed on the basis of computation of stress behavior at the location of the events. Stresses have been computed using standard elastic continuous boundary element models. The correlation between the average source radius and the stress performance has provided a method to propose a macrocracking criterion. Several techniques have been tested to nucleate the microseismic activity around different geological features. This last attempt was aimed to look at potential overstresses induced over the undercut and extraction level drifts. A method was devised to integrate the microseismicity into a 3-dimensional ride distribution model. This model has shown to be very effective to quantify the overstress induced as a result of computing volumetric microseismicity density. The volumetric microseismic model showed to induce overstress up to 10 MPa over a period of two months. The future work will concentrate on the calibration of the integrated model with actual damage observations made at the current mining infrastructure.

关键词： microseism underground mining block caving stress distribution microcrack criterion

Viability,behavior,and color expression in the offspring of matings between common wall lizard Podarcis muralis color morphs

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Current Zoology 2022年第1期68卷 41-55页

作者： Javier ABALOS Guillem PEREZ I de LANUZA Alicia BARTOLOME Fabien AUBRET Tobias ULLER enrique FONT Ethology Lab Instituto Cavanilles de Biodiversidad y Biologı´a EvolutivaUniversitat de ValenciaValenciaSpain CIBIO/InBIO Centro de Investigacao em Biodiversidade e Recursos Geneticos da Universidade do PortoPortoPortugal SETE Station d’Ecologie Theorique et ExperimentaleUPR2001Centre National de la Recherche ScientifiqueParisFrance department of Biology Lund UniversityLundSweden

Color polymorphisms are widely studied to identify the mechanisms responsible for the origin and maintenance of phenotypic variability in *** of the mechanisms of balancing selection currently thought to explain the long-term persistence of polymorphisms are the evolution of alternative phenotypic optima through correlational selection on suites of traits including color and *** of these mechanisms can generate differences in offspring viability and fitness arising from different morph ***,we examined the effect of parental morph combination on fertilization success,embryonic viability,newborn quality,antipredator,and foraging behavior,as well as inter-annual survival by conducting controlled matings in a polymorphic lacertid Podarcis muralis,where color morphs are frequently assumed to reflect alternative phenotypic optima(e.g.,alternative reproductive strategies).Juveniles were kept in outdoor tubs for a year in order to study inter-annual growth,survival,and morph *** agreement with a previous genome-wide association analysis,morph frequencies in the year-old juveniles matched the frequencies expected if orange and yellow expressions depended on recessive homozygosity at 2 separate *** findings also agree with previous literature reporting higher reproductive output of heavy females and the higher overall viability of heavy newborn lizards,but we found no evidence for the existence of alternative breeding investment strategies in female morphs,or morphcombination effects on offspring viability and *** conclude that inter-morph breeding remains entirely viable and genetic incompatibilities are of little significance for the maintenance of discrete color morphs in *** from the Pyrenees.

关键词： alternative breeding strategies color polymorphism controlled matings lizard behavior morph ontogeny newborn viability

Internal Controllability for Parabolic Systems Involving Analytic Non-local Terms

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Chinese Annals of Mathematics,Series B 2018年第2期39卷 281-296页

作者： Pierre LISSY enrique ZUAZUA This article is dedicated to Phillippe G. Ciarlet in the occasion of his 80th birthday with gratitude and admiration/or his mastery and continuous support. Merci Philipp

This paper deals with the problem of internal controllability of a system of heat equations posed on a bounded domain with Dirichlet boundary conditions and perturbed with analytic non-local coupling terms. Each component of the system may be controlled in a different subdomain. Assuming that the unperturbed system is controUable--a property that has been recently characterized in terms of a Kalman-like rank condition--the authors give a necessary and sufficient condition for the controllability of the coupled system under the form of a unique continuation property for the corresponding elliptic eigenvalue system. The proof relies on a compactness-uniqueness argument, which is quite unusual in the context of parabolic systems, previously developed for scalar parabolic equations. The general result is illustrated by two simple examples.

关键词： Parabolic systems Non-local potentials Analyticity Null controllability Kalma~ rank condition Spectral unique continuation

On the material dependence of experimental shear fracture orientation

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Science China Earth Sciences 2015年第12期58卷 2357-2362页

作者： enrique GOMEZ-RIVAS Albert GRIERA department of Geology and Petroleum Geology School of Geosciences King’s College University of Aberdeen departament de Geologia Universitat Autònoma de Barcelona

It is not uncommon to observe shear fractures in ductile rocks oriented at more than 45° with respect to the maximum compression direction. Since these orientations cannot be explained with the classic Mohr-Coulumb or Tresca yield criteria, Zheng et al.(Journal of Structural Geology, 35: 1394–1405, 2011) proposed the maximum effective moment(MEM) failure criterion. This rule suggests that shear fractures in ductile rocks form at ?55° with the maximum compression axis and that this orientation is material-independent and, therefore, universal. Zheng et al.(Science China: Earth Sciences, 57(11): 2819–2824, 2014) used data from our own experiments as supporting evidence of their failure criterion. In this contribution we discuss why shear fracture formation in ductile rocks indeed strongly depends on the mechanical properties of the deforming medium, and why experimental data should not be taken to prove the validity of the MEM criterion. The formation mechanisms and orientations of shear fractures in our experiments significantly vary depending on the material strength and degree and type of anisotropy(composite and intrinsic). We therefore demonstrate using experimental data that a universal failure angle in ductile and anisotropic rocks does not apply. Additionally, we highlight some inconsistencies of the MEM criterion.

关键词： shear fracture anisotropy fracture orientation material properties failure criteria ductile deformation

A UNIFIED FRAMEWORK FOR SITE SELECTION AND BUSINESS FORECASTING USING ANP

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Journal of Systems Science and Systems Engineering 2006年第2期15卷 178-188页

作者： enrique MU Katz Graduate School of Business University of PittsburghUSA

This paper reports an on-going application of the Analytic Network Process （ANP） in the context of a non-profit organization： The Latin American Studies Association （LASA）. This institution organizes a large international conference every eighteen months and needs to estimate conference attendance in advance （for logistic purposes） as well as selecting a host city where the combination of hotel infrastructure, conference costs, and so on, makes it a sound financial choice. In this paper, ANP will be used to： first, create a model to predict the relative number of attendees to the forthcoming 2009 LASA conference; and second, to create a Benefit-Cost-Risk （BCR） model to select the most suitable Latin American city as the conference site, This paper shows how the combination of these two ANP models, one for prediction and one for selection, can be used together for effective decision-making.

关键词： ANP AHE non-profit decision-making predictive models site selection

demonstration of uncertainty resulting from MOderate resolution Imaging Spectroradiometer-like geometries:an albedo case study

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International Journal of Digital Earth 2016年第5期9卷 520-544页

作者： enrique L.Montaño department of Geographical Sciences University of MarylandCollege ParkMDUSA

This research examines uncertainty in MOderate resolution Imaging Spectroradiometer(MODIS)observations,and demonstrates the direct influence of geometric distortions resulting from the standard practice of geolocating swath *** observations vary dependent on the ground sample distance,which varies dependent on the view zenith angle that changes with every *** Level 2G(L2G)land products are generated by applying a geolocation algorithm that resamples the variable observation geometries to a consistent grid of fixed pixel size and location,a process which itself introduces variability associated with the changing observational *** this study,broadband albedo was simulated for five validation sites,representing five distinct land cover types,exhibiting quantifiable variability,with additional seasonal variability exhibited in some *** site simulations exhibit compounded uncertainty attributable to the geometric distortion sufficient to influence climate models(*** from 0.01 to 0.045 albedo).These results indicate there is a minimum level of uncertainty associated with the variable geometry that should be factored into L2Gbased products,particularly for nominal 250 m band *** the data to coarser resolutions and smoothing the data through average resampling can mitigate the uncertainty.

关键词： Earth observation geography land cover remote sensing visible/infrared remote sensing

Stable and non-symmetric pitchfork bifurcations

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Science China Mathematics 2020年第9期63卷 1837-1852页

作者： enrique Pujals Michael Shub Yun Yang department of Mathematics Graduate CenterCity University of New YorkNew YorkNY 10016USA department of Mathematics City College of New YorkNew YorkNY 10031USA department of Mathematics Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA

In this paper,we present a criterion for pitchfork bifurcations of smooth vector elds based on a topological *** result expands Rajapakse and Smale's result[15]signi *** on our criterion,we present a class of families... 详细信息

关键词： pitchfork bifurcation index non-symmetric vector eld center manifold