Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression
作者机构：Posgrado en Ciencias GenómicasUniversidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Facultad de Medicina Veterinaria y ZootecniaUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico Colegio de Ciencias y HumanidadesUniversidad Autónoma de la Ciudad de MéxicoCDMX 03100Mexico Instituo de Fisiología CelularUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2024年第15卷第2期
页 面：195-207页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Interferon-gamma IFNGR1 JAK1 Antiviral Anti-tumor Lung adenocarcinoma
摘 要：Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of *** deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer *** particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γ*** this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in ***,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus *** addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.
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