Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic-ischemic brain injury

作     者：Lara-Celador I. Goi-de-Cerio F. Antonia Alvarez Enrique Hilario 

作者机构：Department of Cell Biology and HistologySchool of Medicine and DentistryUniversity of the Basque Country GAIKER Technology CentreBizkaia Science and Technology Park 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第8期

页      面：731-744页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by grants from Funding Health Care of Spanish Ministry of Health,No. PS09/ 02326 from the Basque Government,No. GCI-07/79,IT-287-07 

主　　题：neural regeneration reviews perinatal hypoxia-ischemia brain injury brain plasticity,neuroprotective strategies cannabinoid system grants-supported paper photographs-containingpaper neuroregeneration 

摘      要：One of the most important causes of brain injury in the neonatal period is a perinatal hypoxicischemic *** devastating condition can lead to long-term neurological deficits or even *** hypoxic-ischemic brain injury,a variety of specific cellular mechanisms are set in motion,triggering cell damage and finally producing cell *** therapeutic treatments against this phenomenon are still unavailable because of complex molecular mechanisms underlying hypoxic-ischemic brain *** a thorough understanding of the mechanism underlying neural plasticity following hypoxic-ischemic brain injury,various neuroprotective therapies have been developed for alleviating brain injury and improving long-term *** them,the endocannabinoid system emerges as a natural system of *** endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury,acting as a natural *** aim of this review is to study the use of different therapies to induce long-term therapeutic effects after hypoxic-ischemic brain injury,and analyze the important role of the endocannabinoid system as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.