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Two Cases of Multi-antibiotic Resistant Cronobacter spp. Infections of Infants in China＊

Biomedical and Environmental Sciences 2017年第8期30卷 601-605页

作者： cui Jing Hua YU Bo XIANG Yun ZHANG Zhen ZHANG Ting ZENG Ying Chun cui zhi gang HUO Xi Xiang State Key Laboratory for infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Hubei provincial center for disease control and prevention Wuhan 430079 Hubei China Department of Laboratory Medicine Wuhan Medical and Health Center for Women and Children Tongji Medical College Huazhong University of Science and Technology Wuhan 430015 Hubei China

Infections by Cronobacter spp. are hazardous to infants since they can lead to neonatal meningitis, bacteremia, and necrotizing enterocolitis. Cronobacter spp. are frequently resistant to 13-1actam derivatives, macrolides, and aminoglycosides. In addition, multi-resistant strains have also been detected. In China, the isolation rate of Cronobacter spp. from commercial powdered infant formula （PIF） or follow-up formula （FUF） is relatively high. Nevertheless, clinical cases of Cronobacter infection have been ignored to date. Here we describe two cases of Cronobacter infection detected at the Wuhan Women and Children Medical Care Center Hospital （Wuhan City, China）. We provide the genomic analysis of the isolates and the antibiotic-resistance profiles of the two strains. The Cronobacter strains identified in this study were not susceptible to third-generation cephalosporins, aminoglycoside, and/or trimethoprim-sulfamethoxazole. Whole genome sequencing revealed various genes known to encode antibiotic resistance. Future studies are needed to determine whether the genes predicted in this study are functional. As with Enterobocter spp., the antibiotic resistance of Cronobocter is a serious issue that requires more attention.

关键词： Multi-antibiotic resistant Cronobacter spp. Infant Case report

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Genetic Diversity, Antimicrobial Resistance, and Virulence Genes of Aeromonas Isolates from Clinical Patients, Tap Water Systems, and Food

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Biomedical and Environmental Sciences 2020年第6期33卷 385-395页

作者： MENG Shuang WANG Yong Lu LIU Chen Geng YANG Jing YUAN Min BAI Xiang Ning JIN Dong LIANG Jun Rong cui zhi gang LI Juan State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 10026China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang 310058HangzhouChina Ma'anshan Center for Disease Control and Prevention Ma'anshan 243031AnhuiChina Clinical Laboratoty of Xuanwu Hospital Captital Medcial University'Beijing 100053China

Objective This study aimed to evaluate the genetic diversity,virulence,and antimicrobial resistance of Aeromonas isolates from clinical patients,tap water systems,and *** Ninety Aeromonas isolates were obtained from Ma’anshan,Anhui province,China,and subjected to multi-locus sequence typing(MLST)with six housekeeping *** taxonomy was investigated using concatenated gyr B-cpn60 sequences,while their resistance to 12 antibiotics was *** putative virulence factors and several resistance genes were identified by PCR and *** The 90 Aeromonas isolates were divided into 84 sequence types,80 of which were novel,indicating high genetic *** Aeromonas isolates were classified into eight different *** assays identified virulence genes in the isolates,with the enterotoxin and hemolysin genes act,aer A,alt,and ast found in 47(52.2%),13(14.4%),22(24.4%),and 12(13.3%)of the isolates,*** majority of the isolates(≥90%)were susceptible to aztreonam,imipenem,cefepime,chloramphenicol,gentamicin,tetracycline,and ***,several resistance genes were detected in the isolates,as well as a new mcr-3 *** Sequence type,virulence properties,and antibiotic resistance vary in Aeromonas isolates from clinical patients,tap water systems,and food.

关键词： Aeromonas Multi-locus sequence typing Multidrug resistance Virulence gene Antimicrobial resistance gene

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Ground states and first radial excitations of vector tetraquark states with explicit P-waves via QCD sum rules

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Chinese Physics C 2024年第10期48卷 40-47页

作者： zhi-gang Wang Department of Physics North China Electric Power UniversityBaoding 071003China

In this study,we chose the diquark-antidiquark type four-quark cuents with an explicit P-wave betweenthe diquark and antidiquark pairs to study the ground states and first radial exeitations of the hidden-charm *** states with quantum numbers J^(PC)=1^(--).We also obtained the lowest vector tetraguark masses and made *** assignments of the existing Ystates,There indeed exists a hidden-charm tetraquark state with J^(PC)=1^(--) at anenergy of approximately 4.75 GeV as the first radial exeitation that accounts for the BESIII data.

关键词： tetraguark state QCD sum rules

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B_(c) meson and its scalar cousin with QCD sum rules

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Chinese Physics C 2024年第10期48卷 48-58页

作者： zhi-gang Wang Department of Physics North China Electric Power UniversityBaoding 071003China

In this study,we use the optical theorem to calculate the next-to-leading order corrections to the QCD spectral densities directly in the QCD sum rules for the pseudoscalar and scalar B_(c) *** use experimental data for guidance to perform an updated *** obtain the masses and,in particular,decay constants,which are the fundamental input parameters in high energy ***,we obtain the pure leptonic decay widths,which can be compared with experimental data in the future.

关键词： next-to-leading order contributions QCD sum rules

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Progress on the glassy-crystal laminates:From design,microstructure to deformation and future solutions

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Journal of Materials Science & Technology 2024年第5期172卷 113-144页

作者： Yu Chen Ronggao cui Jun Shen gang Wang College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Department of Motor Design Business Weichai New Energy Technology Co.Ltd.Weifang 261061China Guangdong Key Laboratory of Electromagnetic Control and Intelligent Robots Shenzhen UniversityShenzhen 518060China Laboratory for Microstructures Institute of MaterialsShanghai UniversityShanghai 200444China

The development of new design strategies to create innovative structural materials,refine existing ones,and achieves compatible combinations of strength and plasticity remains a worldwide *** alloys,such as shape memory alloys(SMAs),bulk metallic glasses(BMGs),high entropy alloys(HEAs),and heterogeneous pure metals such as Cu,have excellent mechanical responses,but they still fall short of meeting all the requirements of structural materials due to specific flaws,such as lack of tensile de-formation for BMGs and low yielding strength for *** address these shortcomings,proposals such as integrating glassy matrices and crystallized alloys,such as HEAs/SMAs,have been ***,these solutions have unresolved issues,such as the challenging control of B2 phase formation in BMG ***,glass-crystal(A/C)laminated alloys with alternating layers have been reported to exhibit improved mechanical properties and activated work-hardening behaviors,but they still face press-ing issues such as bonding interfaces and unknown deformation *** review focuses on design routes such as the selection of alloy components and processing techniques,exploration of micro-structural evolution and deformation modes with an increase in strain,and future solutions to address pressing and unsolved *** prominent advantages include diversified deformation mechanisms,such as deformation twinning,martensitic phase transformation,and precipitation hardening,as well as tuned interactive reactions of shear bands(SBs)near the A/C ***,this review provides a promising pathway to design and develop structural materials in the materials field community.

关键词： Glassy-crystal laminates Bulk metallic glasses High entropy alloys Shape memory alloys Microstructure Deformation mechanisms Future solutions

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Comparative Study of the Genetic Diversity, Antimicrobial Resistance, and Pathogenicity of Aeromonas Isolates from Clinical Patients and Healthy Individuals

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Biomedical and Environmental Sciences 2021年第6期34卷 454-464页

作者： MENG Shuang DU Xiao Li WANG Yong Lu QU Feng Tian XIE Gui Lin ZHOU Hai Jian HU Jin Rui QIN Zheng WANG Yue KAN Biao cui zhi gang State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Ma'anshan Center for Disease Control and Prevention Ma'anshan 243000AnhuiChina College of Life Science Northeast Agricultural UniversityHa'erbin 150000HeilongjiangChina School of Public Health Jiamusi UniversityJiamusi 154000HeilongjiangChina

Objective This study was performed to compare the genetic diversity,virulence,and antimicrobial resistance of Aeromonas strains isolated from patients and healthy *** A total of 38 clinical strains and 19 strains from healthy individuals were isolated from the samples collected in Ma’anshan City,Anhui *** taxonomy was investigated using concatenated gyrB-cpn60 sequences,and their resistance to 12 antibiotics was *** pathogenicity of these strains was examined through beta-hemolysis,protease activity,and virulence gene *** The 57 Aeromonas strains were divided into 55 sequence *** these types,21 were novel,suggesting that their genetic diversity was *** Aeromonas isolates could be divided into 7 species,and the positive rates of beta-hemolysis and protease activity were 49.1%and 73.7%,*** detection rate of clinical patients in terms of beta-hemolysis and protease activity was higher than that of healthy *** the four most common Aeromonas strains,*** had the highest detection rate of virulence *** multidrug resistance rate of the clinical isolates was much higher than that of the strains isolated from healthy *** The taxonomy,virulence properties,and antibiotic resistance of Aeromonas isolates from patients differ from those of the isolates from healthy individuals.

关键词： Aeromonas Genetic diversity Multidrug resistance Virulence gene Antimicrobial resistance gene

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Reduction of dinitrogen to ammonia on doped three-atom clusters Nb_(2)M(M=Sc to Cu & Y to Ag)

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Rare Metals 2024年第8期43卷 3810-3818页

作者： Ran Cheng Chao-Nan cui zhi-Xun Luo Beijing National Laboratory for Molecular Science(BNLMS) State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China

Catalytic reduction of dinitrogen to ammonia under mild conditions remains an attractive topic for the purpose of lowering energy ***-atom metal clusters have been proved an ideal model to explore highly efficient catalysts taking advantage of unique geometric/electronic structures and cooperative active *** a study of N2 activation and reduction on seventeen bimetallic Nb_2M(M=Sc to Cu,and Y to Ag) clusters was *** key processes for ammonia fixation(namely nitrogen activation,hydrogenation,and ammonia desorption) are fully studied,and three preferred systems(Nb_2Ni,Nb_2Rh and Nb_2Pd) are highlighted with outstanding catalytic *** d-σ and d-π~* orbital hybridizations between these metal clusters and N_(2) were demonstrated and the internal association with the N≡N bond activation was *** examining the ammonia synthesis on four chosen Nb_(2)M clusters(M=Fe,Ni,Rh and Pd),it can be elucidated that the distal pathway is more favorable than the alternative pathway in these *** work not only clarifies the N_(2) reduction on the bimetallic Nb_(2)M clusters,but also guides efficient bimetallic catalyst design.

关键词： Three-atom cluster catalysis Three-criteria strategy Nitrogen fixation Ammonia synthesis Theoretical calculations

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Genetic Diversity,Antibiotic Resistance,and Pathogenicity of Aeromonas Species from Food Products in Shanghai,China

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Biomedical and Environmental Sciences 2022年第9期35卷 842-853页

作者： QU Feng Tian WANG Wen Qing LIU Qian ZHOU Hai Jian HU Jin Rui DU Xiao Li WANG Yue XUE Jia Qi cui zhi gang XIE Gui Lin MENG Shuang College of Life Science Northeast Agricultural UniversityHa’erbin 150000HeilongjiangChina State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Shanghai Pudong New Area Center for Disease Control and Prevention Shanghai 200136China Laboratory Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Clinic Medical College North China University of Science and TechnologyTangshan 063000HebeiChina

Objective Aeromonas has recently been recognized as an emerging human *** diarrhea is a phenomenon occurring *** study was designed to determine the prevalence,genetic diversity,antibiotic resistance,and pathogenicity of Aeromonas strains isolated from food products in *** Aeromonas isolates(n=79)collected from food samples were analyzed using concatenated gyrB-cpn60 *** antibiotic resistance of these isolates was determined using antimicrobial susceptibility *** was assessed usingβ-hemolytic,extracellular protease,virulence gene detection,*** liquid toxicity(LT),and cytotoxicity *** Eight different species were identified among the 79 *** most prevalent Aeromonas species were ***[62(78.5%)],***[6(7.6%)],***[3(3.8%)],and ***[3(3.8%)].The Aeromonas isolates were divided into 73 sequence types(STs),of which 65 were *** isolates were hemolytic(45.6%)and protease-positive(81.0%).The most prevalent virulence genes were act(73.4%),fla(69.6%),aexT(36.7%),and ascV(30.4%).The results of *** LT and cytotoxicity assays revealed that *** and *** were more virulent than ***,***,and *** resistance genes[tetE,blaTEM,tetA,qnrS,aac(6)-Ib,mcr-1,and mcr-3]were detected in the *** multidrug-resistance rate of the Aeromonas isolates was 11.4%,and 93.7%of the Aeromonas isolates were resistant to *** The taxonomy,antibiotic resistance,and pathogenicity of different Aeromonas species *** Aeromonas isolates *** and *** were highly pathogenic,indicating that food-derived Aeromonas isolates are potential risks for public health and food *** monitoring of food quality and safety will result in better prevention and treatment strategies to control diarrhea illnesses in China.

关键词： Aeromonas Genetic diversity Antibiotic resistance Virulence gene Cytotoxicity assay Multidrug-resistance

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Revolution in thermoelectric cooling using PbSe thermoelectrics by grid plainification

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Science China Materials 2024年第5期67卷 1672-1673页

作者： Xiao-Lei Shi Qingfeng Liu zhi-gang Chen School of Chemistry and Physics ARC Research Hub in Zero-emission Power Generation for Carbon Neutralityand Centre for Materials ScienceQueensland University of TechnologyBrisbaneQueensland4000Australia State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing211816China

Thermoelectric materials and devices enable direct conversion between heat and electricity,holding potential applications in thermoelectric power generation,localized cooling,and electronic thermal management[1].Howev... 详细信息

关键词： enable thermoelectric constrained

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Combustion mechanism of benzene in iron ore sintering process:experimental and simulation

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Journal of Iron and Steel Research International 2024年第1期31卷 195-203页

作者： zhi-gang Que Jin-ming Shi Xian-bin Ai Institute of Energy Research Jiangxi Academy of ScienceNanchang330096JiangxiChina Jiangxi Carbon Neutralization Research Center Nanchang330096JiangxiChina

Benzene is a typical component of volatile organic compounds(VOCs)in the iron ore sintering flue *** combustion behavior of benzene directly affects the emission of VOCs in iron ore sintering *** effects of temperature,benzene,and oxygen concentrations on the conversion ratio of benzene were investigated by experiments and numerical *** experiments were carried out in a tube reactor at temperatures of 773-1098 K,benzene concentrations of 0.01-0.03 vol.%,and oxygen concentrations of 10-21 vol.%.The numerical simulation was performed with the plug flow model in the CHEMKIN program based on a kinetic model that consists of 132 chemical species and 772 elementary step-like *** experimental results reveal that increasing the temperature and benzene concentration could signifi-cantly promote benzene *** is attributed to the increase in the reaction rates of all steps in the pathway for forming CO_(2)and H_(2)*** addition,due to the large equivalent ratio of oxygen to benzene,the conversion ratio of benzene remained constant at different oxygen *** simulation results were in good agreement with the experimental results and indicated that six elementary reactions dominated the formations of CO_(2)and H_(2)*** oxidations of C_(6)H_(5)O,CO,and C_(5)H_(4)O intermediates to CO_(2)were the limiting steps in the reaction pathways.

关键词： Benzene Volatile organic compound Iron ore sinter Combustion Simulation Temperature Oxygen

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