Genetic Diversity, Antimicrobial Resistance, and Virulence Genes of Aeromonas Isolates from Clinical Patients, Tap Water Systems, and Food

作     者：MENG Shuang WANG Yong Lu LIU Chen Geng YANG Jing YUAN Min BAI Xiang Ning JIN Dong LIANG Jun Rong CUI Zhi Gang LI Juan MENG Shuang;WANG Yong Lu;LIU Chen Geng;YANG Jing;YUAN Min;BAI Xiang Ning;JIN Dong;LIANG Jun Rong;CUI Zhi Gang;LI Juan

作者机构：State Key Laboratory of Infectious Disease Prevention and ControlNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 10026China Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesZhejiang 310058HangzhouChina Ma'anshan Center for Disease Control and PreventionMa'anshan 243031AnhuiChina Clinical Laboratoty of Xuanwu HospitalCaptital Medcial University'Beijing 100053China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2020年第33卷第6期

页      面：385-395页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China grant numbers NSFC 81861138053 and NSFC 31761133004 

主　　题：Aeromonas Multi-locus sequence typing Multidrug resistance Virulence gene Antimicrobial resistance gene 

摘      要：Objective This study aimed to evaluate the genetic diversity,virulence,and antimicrobial resistance of Aeromonas isolates from clinical patients,tap water systems,and *** Ninety Aeromonas isolates were obtained from Ma’anshan,Anhui province,China,and subjected to multi-locus sequence typing(MLST)with six housekeeping *** taxonomy was investigated using concatenated gyr B-cpn60 sequences,while their resistance to 12 antibiotics was *** putative virulence factors and several resistance genes were identified by PCR and *** The 90 Aeromonas isolates were divided into 84 sequence types,80 of which were novel,indicating high genetic *** Aeromonas isolates were classified into eight different *** assays identified virulence genes in the isolates,with the enterotoxin and hemolysin genes act,aer A,alt,and ast found in 47(52.2%),13(14.4%),22(24.4%),and 12(13.3%)of the isolates,*** majority of the isolates(≥90%)were susceptible to aztreonam,imipenem,cefepime,chloramphenicol,gentamicin,tetracycline,and ***,several resistance genes were detected in the isolates,as well as a new mcr-3 *** Sequence type,virulence properties,and antibiotic resistance vary in Aeromonas isolates from clinical patients,tap water systems,and food.