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Species biodiversity of yeasts inhabited in different organic materials in Taiwan

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Species biodiversity of yeasts inhabited in different organi...

A Review of Technical Requirements for High Penetration of Wind Power Systems

海峡两岸第十届菌物学暨第三届食药用菌学术研讨会

作者： hsieh Chin-Wen CHUGi-Han LEE ching-Fu Department of Applied Science Hsinchu University of EducationTaiwan

The species diversity of yeasts inhabited on soil,leaves and mushrooms were investigated on mountain area in Taiwan during ***-five hundred and thirty-seven strains of the yeasts studied in this report were isolated from 860 samples of soil,leaves and fruiting body of mushrooms distributed on mountain area in *** the isolates were selected by PCR- fingerprinting with primers M13 and(GTG),and the isolates from the same clone will not be repeatedly *** of the selected yeast strains were identified based on fermentation,morphological and biochemical *** 3,537 strains of yeasts were classified into 57 genus and 557 species based on the traditional and molecular *** found the yeast flora showed significant diversity in soil,leaves and mushrooms,respectively.

关键词： yeast PCR- fingerprinting diversity Taiwan

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Journal of Power and Energy Engineering 2014年第12期2卷 11-17页

作者： Yuan-Kang Wu Tung-ching Lee Ting-Yen hsieh Wei-Min Lin Department of Electrical Engineering National Chung-Cheng University Chiayi Taiwan Green Energy and Environment Research Laboratories Industrial Technology Research Institute Hsinchu Taiwan

Renewable portfolio targets have been established in many regions around the world. Regional targets such as 20% renewable energy by year 2020 are not uncommon. As the levels of wind power penetration increase, there are many power system impacts. This work investigated possible challenges and technical requirements for high penetration of wind power systems. The main issues to discuss covers reserve determination, wind power forecasting, unit commitment with appropriate generation portfolio, wind turbine and storage system technical development, demand response management, electricity market design, and frequency stability.

关键词： Renewable High Penetration Wind Power

Revisiting vitamin C in cancer therapy:Is“C”for cure,or just wishful thinking?

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Genes & Diseases 2016年第1期3卷 1-2页

作者： Fei Li Lin Zhang Shou-ching tang The Editorial Office of Genes&Diseases ChongqingChina University of Pittsburgh Cancer Institute PittsburghPAUSA Georgia Regents University Cancer Center AugustaGAUSA Tianjin Medical University Cancer Institute and Hospital TianjinChina

We devoted this short piece to highlight one recent article published in Science,which revisited the anti-cancer efficacy of high-dose vitamin *** isogeneic KRAS-and BRAF-mutated colorectal cell lines,the authors were able to demonstrate selective antitumor effects among the KRAS-and BRAF-mutated cells in culture and in ex-planted animal models treated with high-dose vitamin *** elegant and in-depth studies unequivocally tied the tumoricidal effect to the heightened sensitivity of the mutant cells due to the increased vitamin C uptake,leading to lethal accumulation of reactive oxygen species(ROS).This report will certainly rekindle enthusiasm in revisiting the case of vitamin C,pushing for more definitive cancer therapy trials.

关键词： BRAF Cancer Chemotherapy KRAS Vitamin C

Hepcidin-25 negatively predicts left ventricular mass index in chronic kidney disease patients

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World Journal of Nephrology 2013年第2期2卷 38-43页

作者： Yao-Peng hsieh ching-Hui Huang Chia-Ying Lee Hung-Lin Chen ching-Yuang Lin Chia-Chu Chang Division of Nephrology Department of Internal Medicine Changhua Christian Hospital College of Management MingDao University Division of Cardiology Department of Internal Medicine Changhua Christian Hospital College of Medicine China Medical University Department of Medical Nutrition Therapy and Food Service Changhua Christian Hospital Division of Pediatric Nephrology China Medical University Hospital Clinical Immunological Center China Medical University Hospital School of Medicine Chung Shan Medical University

AIM: To assess the correlation between the serum hepcidin-25 level and left ventricular mass ***: This study was a cross-sectional study conducted between March 2009 and April 2010. Demo-graphic and biochemical data, including the serum hepcidin-25 level, were collected for chronic kidney disease(CKD) patients. Two-dimensional echocardiography was performed to determine the left ventricle mass(LVM), left ventricular mass index(LVMI), interventricular septum thickness(IVSd), left ventricle posterior wall thickness(LVPW), right ventricular dimension(RVD), left atrium(LA) and ejection fraction(EF).RESULTS: A total of 146 patients with stage 1 to 5 CKD were enrolled. Serum hepcidin-25 levels were 16.51 ± 5.2, 17.59 ± 5.32, 17.38 ± 6.47, 19.98 ± 4.98 and 22.03 ± 4.8 ng/mL for stage 1 to 5 CKD patients, respectively. Hepcidin-25 level was independently predicted by the serum ferritin level(β = 0.6, P = 0.002) and the estimated glomerular filtration rate(β =-0.48, P = 0.04). There were negative correlations between the serum hepcidin level and the LVM and LVMI(P = 0.04 and P = 0.005, respectively). Systolic blood pressure(BP) was positively correlated with the LVMI(P = 0.005). In the multivariate analysis, a decreased serum hepcidin-25 level was independently associated with a higher LVMI(β =-0.28, 95%CI:-0.48--0.02, P = 0.006) after adjusting for body mass index, age and systolic BP. CONCLUSION: A lower serum hepcidin level is associated with a higher LVMI in CKD patients. Low hepcidin levels may be independently correlated with unfavorable cardiovascular outcomes in this population.

关键词：血清肾小球治疗方法临床分析

TFT-LCD用黑色光刻胶材料对曝光过程Mark读取的影响

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液晶与显示 2023年第8期38卷 1047-1053页

作者：李吉张霞廖昌谢忠憬尹勇明孟鸿北京大学深圳研究生院广东深圳518055 北京大学材料科学与工程学院北京100871 深圳北理莫斯科大学广东深圳518172 TCL华星光电技术有限公司广东深圳518132

大尺寸薄膜晶体管液晶显示器(Thin Film Transistor Liquid Crystal Display,TFT-LCD)显示器为节省黑色矩阵(Black Matrix,BM)制程降低面板成本,使用黑色膜柱(Black Photo Spacer,BPS)技术替代BM和PS(Photo Spacer)制程,同时为兼顾对组精度提升的需求,采用BOA(BPS on Array)技术,将BPS转移至阵列基板侧。原BM制程是第一道制作,而新的BPS制程则位于阵列最后一道制程。BPS曝光成型需使用阵列前制程的金属标(Metal Mark)进行精准对位,实现精细化图案。BPS的透过率低,致使CCD摄像机透过BPS抓取前制程的金属标进行对位非常困难。针对该技术难题,对曝光设备抓标的原理进行了分析,通过调整材料颜料组成,获取了不同透过率BPS材料。将不同透过率的BPS材料进行曝光成型,研究曝光对位过程对材料透过率的最低要求,同时遮光度尽可能大。实验结果表明,NSK曝光机对位灯源波长位于780~1000 nm红外区域,在该波段BPS材料透过率低于23%时会导致对位失败。通过使用有机-无机混合颜料组成取代有机混合颜料,在红外波段可获得接近90%的透过率,满足对位需求。同时固化成型后可获得1.2/μm光学密度,满足BPS产品遮光特性需求。以此制作的BPS面板光学指标满足产品规格。

关键词： TFT-LCD BPS技术曝光工艺抓标对位透过率

An Adaptive Activation Function for Multilayer Feedforward Neural Networks

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An Adaptive Activation Function for Multilayer Feedforward N...

Real-world effectiveness of direct-acting antivirals in people living with human immunodeficiency virus and hepatitis C virus genotype 6 infections

2002年IEEE十区计算机、通信、控制和电机工程会议

作者： Chien-ChengYu Yun-ching tang Department of Electrical Engineering National Cheng Kung University Tainan Taiwan China 70101 Department of Electrical Engineering Hsinping Institute of Technology Taichung Taiwan China 412 Department of Electrical Engineering Hsinping Institute of Technology Taichung Taiwan China 412

The aim of this paper is to propose a new adaptiveactivation function for multilayer feedforward neural *** upon the back-propagation (BP) algorithm, an effectivelearning method is derived to adjust the free parameters in theactivation function as well as the connected weights betweenneurons. Its performance is demonstrated by the N-parity andtwo-spiral problems. The simulation results showed that theproposed method is more suitable to the pattern classificationproblems and its learning speed is much faster than that oftraditional networks with fixed activation function.

关键词： activation function multilayer feedforward neural networks Back-propagation

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World Journal of Gastroenterology 2022年第11期28卷 1172-1183页

作者： Hsin-Yun Sun Chien-Yu Cheng Chi-Ying Lin Chia-Jui Yang Nan-Yao Lee Bo-Huang Liou Hung-Jen tang Yuang-Meng Liu Chun-Yuan Lee Tun-Chieh Chen Yi-Chia Huang Yuan-Ti Lee Ming-Jui Tsai Po-Liang Lu Hung-Chin Tsai Ning-Chi Wang Tung-Che Hung Shu-Hsing Cheng Chien-ching Hung Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of MedicineTaipei 100225TaiwanChina Department of Infectious Diseases Taoyuan General HospitalMinistry of Health and WelfareTaoyuan 330215TaiwanChina School of Public Health National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Internal Medicine National Taiwan University Hospital Yun-Lin BranchYun-Lin County 640203TaiwanChina Department of Internal Medicine Far Eastern Memorial HospitalNew Taipei City 220216TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Medicine National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 704302TaiwanChina Department of Internal Medicine Hsinchu MacKay Memorial HospitalHsin-Chu 300044TaiwanChina Department of Internal Medicine Chi Mei Medical CenterTainan 710402TaiwanChina Department of Health and Nutrition Chia Nan University of Pharmacy and SciencesTainan 717301TaiwanChina Department of Internal Medicine Changhua Christian HospitalChanghua 500209TaiwanChina Department of Internal Medicine Kaohsiung Medical University Hospital and College of MedicineKaohsiung Medical UniversityKaohsiung 807378TaiwanChina Department of Internal Medicine Kaohsiung Municipal Ta-Tung HospitalKaohsiung 801735TaiwanChina Department of Internal Medicine National Taiwan University Hospital Biomedical Park BranchHsin-Chu 302058TaiwanChina Department of Internal Medicine Chung Shan Medical University HospitalTaichung 402306TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 402306TaiwanChina Department of Internal Medicine Kaohsiung Medical University Hospital and College of MedicineKaohsiung Medical UniversityKaohsiung 807377TaiwanChina Department of Internal Medicine Kaohsiung Veterans General HospitalKaohsiung 813414TaiwanChina Department of Internal Medicine Tri-Service General HospitalNational Defen

BACKGROUND Hepatitis C virus(HCV)genotype 6(HCV-6)infection is prevalent predominantly in Southeast Asia,and the data on the virologic response of HCV-6 to direct-acting antivirals(DAAs)are sparse in people living with human immunodeficiency virus(HIV)(PLWH).AIM To assess the virologic response of HCV-6 to DAAs in *** From September 2016 to July 2019,PLWH coinfected with HCV-6 initiating DAAs were *** investigations were performed at baseline,the end of treatment,and 12 wk *** Of the 349 PLWH included(mean age 48.9 years,82.5%men),80.5%comprised people who inject drugs,18.1%men who have sex with men,and 1.4%*** hepatitis B virus infection was present in 12.3%of the included PLWH,liver cirrhosis 10.9%,hepatocellular carcinoma 0.9%,and previous HCV treatment experience 10.9%.The mean baseline plasma HCV RNA was 6.2 log10 IU/m *** with glecaprevir/pibrentasvir was initiated in 51.9%,sofosbuvir/ledipasvir 41.5%,sofosbuvir/velpatasvir 6.3%,and sofosbuvir/daclatasvir 0.3%.At DAA initiation,antiretroviral therapy containing tenofovir alafenamide was given in 26.4%,tenofovir disoproxil fumarate 34.4%,non-tenofovir alafenamide/tenofovir disoproxil fumarate 39.3%,non-nucleoside reverse-transcriptase inhibitors 30.4%,protease inhibitors 4.0%,and integrase strand transfer inhibitors 66.8%;94.8%of the included patients had CD4 counts≥200 cells/mm3 and 96.0%had plasma HIV RNA<50 copies/m ***,96.8%achieved undetectable plasma HCV RNA(<30 IU/m L)at end of treatment;and 92.3%achieved sustained virologic response 12 wk off-therapy in the intention-to-treat analysis(93.5%in patients receiving sofosbuvir-based DAAs and 91.2%in those receiving glecaprevir/pibrentasvir).CONCLUSION Similar to the observation made in HIV-negative patients,sustained virologic response 12 wk offtherapy with DAAs is high in PLWH coinfected with HCV-6.

关键词： Viral hepatitis End-of-treatment response Sustained virologic response People who inject drugs Antiretroviral therapy Tenofovir

Targeted therapy in non-small cell lung cancer

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中国肺癌杂志 2004年第4期7卷 284-289页

作者： Shou-ching tang Solid Tumor Oncology University of Miami Sylvester Comprehensive Cancer Center Associate Professor of Medicine Division of Hematology and Oncology University of Miami MD PhD FACP FRCPC

1 IntroductionRecent progress in molecular biology has enabled us to better understand the molecular mechanism underlying pathogenesis of human malignancy including lung cancer. Sequencing of human genome has identified many oncogenes and tumor suppressor genes,giving us a better understanding of the molecular events leading to the formation, progression, metastasis, and the development of drug resistance in human lung cancer. In addition, many signal transduction pathways have been discovered that play important roles in lung cancer. Novel strategy of anti-cancer drug development now involves the identification and development of targeted therapy that interrupts one or more than one pathways or cross-talk among different signal transduction pathways. In addition, efforts are underway that combine the traditional cytotoxic (non-targeted) agents with the biological (targeted) therapy to increase the response rate and survival in patients with lung cancer, especially advanced non-small cell lung cancer (NSCLC).

关键词：非小细胞肺癌肿瘤靶向治疗 EGFR 生物学

Human Factors of LCD Displays in Motion Environment—Reading Accuracy and Visual Fatigue

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Human Factors of LCD Displays in Motion Environment—Reading...