Revisiting vitamin C in cancer therapy:Is“C”for cure,or just wishful thinking?

作     者：Fei Li Lin Zhang Shou-Ching Tang 

作者机构：The Editorial Office of Genes&DiseasesChongqingChina University of Pittsburgh Cancer InstitutePittsburghPAUSA Georgia Regents University Cancer CenterAugustaGAUSA Tianjin Medical University Cancer Institute and HospitalTianjinChina 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2016年第3卷第1期

页      面：1-2页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Work in Dr.Zhang’s laboratory was supported in part by research grants from the National Institutes of Health of the USA(R01CA106348 R01CA172136 and R01CA203028) 

主　　题：BRAF Cancer Chemotherapy KRAS Vitamin C 

摘      要：We devoted this short piece to highlight one recent article published in Science,which revisited the anti-cancer efficacy of high-dose vitamin *** isogeneic KRAS-and BRAF-mutated colorectal cell lines,the authors were able to demonstrate selective antitumor effects among the KRAS-and BRAF-mutated cells in culture and in ex-planted animal models treated with high-dose vitamin *** elegant and in-depth studies unequivocally tied the tumoricidal effect to the heightened sensitivity of the mutant cells due to the increased vitamin C uptake,leading to lethal accumulation of reactive oxygen species(ROS).This report will certainly rekindle enthusiasm in revisiting the case of vitamin C,pushing for more definitive cancer therapy trials.