Targeted therapy in non-small cell lung cancer
Targeted therapy in non-small cell lung cancer作者机构：Solid Tumor Oncology University of Miami Sylvester Comprehensive Cancer Center Associate Professor of Medicine Division of Hematology and Oncology University of Miami MD PhD FACP FRCPC
出 版 物：《中国肺癌杂志》 (Chinese Journal of Lung Cancer)
年 卷 期：2004年第7卷第4期
页 面：284-289页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：1 IntroductionRecent progress in molecular biology has enabled us to better understand the molecular mechanism underlying pathogenesis of human malignancy including lung cancer. Sequencing of human genome has identified many oncogenes and tumor suppressor genes,giving us a better understanding of the molecular events leading to the formation, progression, metastasis, and the development of drug resistance in human lung cancer. In addition, many signal transduction pathways have been discovered that play important roles in lung cancer. Novel strategy of anti-cancer drug development now involves the identification and development of targeted therapy that interrupts one or more than one pathways or cross-talk among different signal transduction pathways. In addition, efforts are underway that combine the traditional cytotoxic (non-targeted) agents with the biological (targeted) therapy to increase the response rate and survival in patients with lung cancer, especially advanced non-small cell lung cancer (NSCLC).
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