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Helicobacter pylori isolated from gastric juice have higher pathogenic potential than biopsy isolates

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Genes & Diseases 2024年第1期11卷 34-37页

作者： Budhadev Baral Dharmendra Kashyap Nidhi Varshney Tarun prakash Verma Ajay Kumar Jain Debi Chatterji Vinod Kumar Amit Mishra Awanish Kumar Hem chandra Jha Infection Bioengineering Group Department of Biosciences and Biomedical EngineeringIndian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Choithram Hospital and Research Center IndoreMadhya Pradesh452014India Department of Metallurgy Engineering and Materials Science Indian Institute of Technology IndoreSimrolIndoreMadhya Pradesh 453552India Department of Bioscience&Bioengineering Indian Institute of Technology JodhpurNH 65 Nagaur RoadJodhpur DistrictKarwarRajasthan 342037India Department of Biotechnology National Institute of Technology RaipurGE RoadRaipurChhattisgarh 492010India

Persistent gastritis induced by Helicobacter pylori(***)is the strongest known risk factor for gastric cancer(GC).*** is prevalent in about 50%world's population,while it causes cancer in less than 2%of exposed individuals.1 Our studies found that *** infection can induce oncogenic properties in AGS cells by deregulating multiple factors associated with the cell cycle,apoptosis,and other important events associated with cancer progression.

关键词： H.pylori pylori Helicobacter

Correlation of neutrophil to lymphocyte ratio to severity of coronary artery disease and in-hospital clinical outcomes in patients with acute coronary syndrome: A prospective observational study

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Journal of Acute Disease 2024年第1期13卷 14-19页

作者： Vinodhkumar Kandibendla GThiruvikrama prakash Subash chandra Bose Prafull Dhewle Department of Cardiology Prakriya HospitalsNagasandraBangloreIndia Department of Cardiology E.S.HospitalVillupuramTamil NaduIndia Department of Cardiology Government Medical CollegeAnanthapuramuAndhra PradeshIndia Department of Cardiology Shrikrishna Hrudayalaya HospitalNagpurMaharashtraIndia

Objective:To explore correlation of neutrophil-to-lymphocyte ratio(NLR)to severity of coronary artery disease(CAD)and in-hospital clinical outcomes in patients with acute coronary syndrome(ACS).Methods:In this prospective and observational study,we recruited 500 patients with *** all the eligible patients,demographic details were collected,and laboratory parameters were *** CAD severity was evaluated in terms of the number of involved *** NLR was calculated based on neutrophils and lymphocytes and the correlation of various risk factors and severity and outcome of CAD was ***:77.2%of Patients was male,and 52%of the patients aged between 55-70 *** on the type of ACS,396 out of 500 patients had ST-elevation myocardial *** ascending trend in the white blood cell levels and NLR value was noted as the severity of the ACS increased and the highest white blood cell levels and NLR was noted among classⅣ*** mean NLR value among the non-survivors were higher compared to the survivors(9.52±5.72 vs.4.76±2.36;P<0.01).Receiver operating curve showed that the cut-off NLR value was 5.76 with a sensitivity of 75.0%and a specificity of 77.3%.Conclusions:The NLR can be used as an independent prognostic marker in *** elevated NLR value serves as a reliable predictor for short-term complications,notably in-hospital mortality.

关键词： Acute coronary syndrome Coronary artery disease Coronary vessels Hospital mortality Lymphocytes Neutrophils Prognosis Risk factors

Forest structure and anthropogenic pressures in the Pachmarhi biosphere reserve of India

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Journal of Forestry Research 2015年第4期26卷 867-874页

作者： chandra prakash Kala Ecosystem & Environment Management Indian Institute of Forest Management

A critical first step in establishing biosphere reserves--under the Man and Biosphere Programme of UNESCO--is to generate baseline information for future courses of action. The present study aims to assess the structure and composition of forests--along with anthro- pogenic pressures mounting on these forests in the buffer zone of one such biosphere reserves--the Pachmarhi bio- sphere reserve of India. The quadrat method was employed for sampling vegetation, and information on anthropogenic pressures was collected by conducting interviews with local people and forest officials and collecting it from secondary sources. A total of 39 tree species were sampled in 82 quadrats; of these 26 tree species were in standing stage, 25 in sapling, and 35 in seedling. Chloroxylon swi- etenia emerged as the most dominant tree species having highest importance value index, followed by Tectona grandis, Terminalia tomentosa, and Hardwickia binata. Nine tree species and their saplings, including Sterculia urens and Terminalia arjuna, were exploited so badly that they were only found in the seedlings stage. The unavail- ability of standing trees of 12 important tree species including Aegle marmelos and Phyllanthus emblicaindicates the intensity and gravity of anthropogenic pres- sures on these important tree species. If the present anthropogenic pressure continues, which has inhibited the regeneration of several tree species, then substantial neg- ative ecological and societal consequences can be expected.

关键词： Pachmarhi biosphere reserve Tropicalforest Forest composition Forest structure Regeneration Anthropogenic pressures

Mitigating People-Park Conflicts on Resource Use through Ecotourism:A Case of the Nanda Devi Biosphere Reserve,Indian Himalaya

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Journal of Mountain Science 2011年第1期8卷 87-95页

作者： chandra prakash KALA Rakesh Kumar MAIKHURI Ecosystem and Environment Management Indian Institute of Forest Management G.B.Pant Institute of Himalayan Environment and Development Post.

Eeotourism aims to deliver the philosophy of sustainable development through environmental conservation as well as socio-economic development. Areas with rich biodiversity and scenic beauty, like the Indian Himalayan region, have been one of the major destination centers for nature lovers from historical time. In view of conserving the rich biodiversity and natural heritage of the Himalayan region 92 protected areas have been set aside, of these Nanda Devi Biosphere Reserve （NDBR） is a well known world heritage site. Over a period of time establishing NDBR has invited conficts between the local people and reserve authorities on the management approaches and utilization criteria of the natural resources, especially banning the traditional bio-resource collection rights of local community, expeditions, trekking, and other anthropogenic activities in the core zones. The present study aims to understand and analyze the various people - park conflicts, and also to suggest ways to mitigate such conflicts in view of biodiversity conservation and improvement of economic status of local people by promoting eeotourism. With this view the study further discusses the various aspects of eeotourism, its pros and cons, and the avenues of developing appropriate strategies for promotion of ecotourism in buffer zone areas of NDBR.

关键词： Eeo-tourism Indian Himalaya NandaDevi Biosphere Reserve Nature conservation People-park conflicts

Oxygen Fugacity and Water Activity during Thermal Peak and Retrogression of Granulites around the Sarvapuram Area, Karimnagar Granulite Terrane, Andhra Pradesh, India

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Acta Geologica Sinica(English Edition) 2019年第6期93卷 1900-1908页

作者： P.chandra SINGH D.prakash Department of Earth Sciences Indian Institute of TechnologyPowaiMumbai400076India Centre of Advanced Study in Geology Banaras Hindu UniversityVaranasi221005India

The investigated area around Sarvapuram represents a part of the Karimnagar granulite terrane of the Eastern Dharwar Craton, India. Garnet–bearing gneiss is hosted as enclaves, pods within granite gneiss and charnockite. It is largely made up of garnet, orthopyroxene, cordierite, biotite, plagioclase, K–feldspar, sillimanite and quartz. The peak metamorphic stage is represented by the equilibrium mineral assemblage i.e. garnet, orthopyroxene, cordierite, biotite, plagioclase, sillimanite and quartz. Breakdown of the garnet as well as preservation of the orthopyroxene–cordierite symplectite, formation of cordierite with the consumption of the garnet + sillimanite + quartz represents the decompressional event. The thermobarometric calculations suggest a retrograde P–T path with a substantial decompression of c. 3.0 kbar. The water activity(XH2 O) conditions obtained with the win TWQ program for core and symplectite compositions from garnet–bearing gneiss are 0.07–0.14 and 0.11–0.16 respectively. The quantitative estimation of oxygen fugacity in garnet–bearing gneiss reveal log f O2 values ranging from-11.38 to-14.05. This high oxidation state could be one of the reasons that account for the absence of graphite in these rocks.

关键词： metamorphic conditions oxygen fugacity water activity garnet–bearing gneisses Karimnagar granulite terrane India

Community Responses to Mountain Tourism:A Case in Bhyundar Valley,Indian Himalaya

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Journal of Mountain Science 2009年第4期6卷 394-404页

作者： Ram Babu Singh Suraj Mal chandra prakash Kala Department of Geography Delhi School of EconomicsUniversity of Delhi Department of Geography Shaheed Bhagat Singh CollegeUniversity of Delhi Ecosystem and Environment Management Division Indian Institute of Forests Management

Tourism industry has become an important part of Indian economy,and tourism development has been,however,concentrated to a few areas. Accumulation of tourism activities has reached the critical stage in most of the tourism centers,which pose serious threats to the natural environment. The Bhyundar Valley of Nanda Devi Biosphere Reserve (NDBR) in Uttarakhand State of the Indian Himalaya is a burning example of such problems. Land use/cover changes,deforestation and accumulation of garbage are some of the negative impacts of unregulated tourism in the valley. Unsustainable activities of tourists and villagers in the valley make such problems very severe. To deal with the ongoing problems and ensure community involvement in tourism management and environmental conservation,the Biosphere Reserve Authority introduced ecotourism in the form of Eco Development Committees (EDCs) in the Bhyundar Valley. Study reveals that many problems associated with tourism have been minimized to some extent with the help of EDCs but few are still prevailing in valley. However,the existing attempts to conserve the valley from the negative effects of tourism are inadequate and modifications are needed in the current initiatives.

关键词： Mountain tourism Land use change Community response Eco development committee Environmental management

Anthropogenic disturbances and status of forest and wildlife in the dry deciduous forests of Chhattisgarh state in India

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Journal of Forestry Research 2012年第1期23卷 45-52页

作者： chandra prakash Kala Yogesh Dubey Ecosystem & Environment Management Indian Institute of Forest Management P.B. No. 357 Nehru Nagar Bhopal - 462 003 Madhya Pradesh INDIA

The advent of modem forces and the changes in socio- economic patterns of forest dwellers have increased the pressures on the forests. In order to mitigate such pressures and also to protect the forests and wildlife the model of protected areas networks has shifted and en- hanced such pressures in the unprotected natural forests due to several reasons. Being a low profile category of protected status and continuous human settlements, the present study highlights the case of dry deciduous forests of Sarguja district of Chhattisgarh state of India. The major objec- tives of this study were to quantify the status of forests and wildlife and also to determine the extent of anthropogenic disturbances faced by the dry deciduous forests of central India. Transect and silent drive count methods were used for sampling wildlife and quadrat method was used for sampling vegetation. Besides, the local uses of various forest pro- duces were also studied in view of understanding the people dependency on forests. The forest vegetation, in the study area, was pre-dominated by Shorea robusta, which had Madhuca indica, Diospyrus melanoxylon and Buchnania lanzan as the major companion species. The forest had either the high girth class mature tree species or the saplings. The low vegeta- tion cover and density were due to the high anthropogenic pressures mainly in the form of heavy livestock grazing and collection of etlmo- botanically important species. The study though reveals that the area is not rich in wildlife and the forest is fragmented, the area still supports some important species, which include many rare and endangered plants and animals. The findings of this study have been discussed in view of the management and conservation of the forest and wildlife in the dry deciduous forests.

关键词： dry deciduous forest central India wildlife anthropogenicdisturbances biodiversity conservation

Shaping the handicraft cluster through innovation capability

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International Journal of Innovation Studies 2022年第2期6卷 102-117页

作者： Juhi Raghuvanshi chandra prakash Garg Department of Management Studies Indian Institute of Technology DelhiNew Delhi110016India Department of Operations Management&Quantitative Techniques Indian Institute of Management RohtakHaryana124001India J Herbert Smith Centre for Technology Management&Entrepreneurship Faculty of EngineeringUniversity of New BrunswickFrederictonE3B 5A3NBCanada

There are several enablers to the innovation capability in the exisiting literature,but they all are considered with equal *** believe ranking will advance the understanding of academicians and practitioners ***,we started by recognizing the enablers from the available literature and exploring the possible causal relationship among them.A framework based on the causal relationship among the enablers is *** DEMATEL(Decision-making trial and evaluation laboratory)has been used to establish this causal *** study identifies nine of the fifteen enablers as causal *** are as follows:Knowledge Exploration,Ideation and Organizational Structure,Organizational Climate,Risk Taking Ability,Collaboration and Networking,Institutional Support,Rejuvenation and Upgrading,Leadership Practices,Technological ***,academicians,and policymakers will have a better understanding of this causal relationship among *** of these enablers will help in fostering a more conducive environment for escalating the process of innovation in the handicraft cluster.

关键词： Grey theory DEMATEL Innovation Innovation capability Handicraft cluster

Effect of plasma treatment on the seed germination and seedling growth of radish(Raphanus sativus)

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Plasma Science and Technology 2022年第1期24卷 95-107页

作者： Rajesh prakash GURAGAIN Hom Bahadur BANIYA Santosh DHUNGANA Ganesh Kuwar CHHETRI Binita SEDHAI Niroj BASNET Aavash SHAKYA Bishnu prasad PANDEY Suman prakash PRADHAN Ujjwal Man JOSHI Deepak prasad SUBEDI Department of Physics School of SciencesKathmandu UniversityDhulikhelKavre 45210Nepal Department of Physics Tri-Chandra Multiple CampusTribhuvan UniversityKathmandu 44600Nepal Department of Chemical Science and Engineering Kathmandu UniversityDhulikhelKavre 45210Nepal Department of Environmental Science and Engineering Kathmandu UniversityDhulikhelKavre 45210Nepal

The effect on the germination and seedling growth of radish(Raphanus sativus)seeds were examined employing a dielectric barrier discharge(DBD)at atmospheric pressure and room temperature for various treatment *** plasma using argon gas of flow rate 21 m^(-1)was employed in this *** seeds were treated with DBD plasma for 1-5 min,*** characteristics,seedling growth parameters,the contact angle of the seed coat,water uptake capacity,mass loss,the temperature of the seeds,chlorophyll,and carotenoid contents of the seedlings were measured before and after the DBD plasma *** treatment of radish seeds significantly increased germination-related characters,including germination percentage,fresh and dry weight,vigor index,and total carotenoids ***,the cumulative production rate was found to be *** from the experiment indicate an acceleration in the water uptake of the radish seeds and make the seed surface hydrophilic by plasma *** electron microscopy analysis showed that etching effects on the seed coat occurred after the argon plasma treatments,which affected the wettability of the radish *** experimental findings showed that seeds being treated by DBD plasma for 2 and 3 min had a positive effect on the germination and seedling growth of radish.

关键词： dielectric barrier discharge(DBD) electron temperature electron density germination growth parameters radish seeds