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Four plasma membrane-localized MGR transporters mediate xylem Mg^(2+)loading for root-to-shoot Mg^(2+)translocation in Arabidopsis

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Molecular Plant 2022年第5期15卷 805-819页

作者： Su-Fang Meng Bin Zhang Ren-Jie Tang Xiao-Jiang Zheng Rui Chen Cong-Ge Liu Yan-ping Jing Hai-Man Ge chi Zhang Yan-Li Chu ai-Gen Fu Fu-Geng Zhao Sheng Luan Wen-Zhi Lan State Key Laboratory for Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023JiangsuChina Institute of Future Agriculture Northwest A&F UniversityYangling 712100ShaanxiChina The Key Laboratory of Western Resources Biology and Biological Technology College of Life SciencesNorthwest UniversityXi'an 710069China Department of Plant and Microbial Biology University of CaliforniaBerkeleyCA 94720USA

Magnesium(Mg^(2+)),an essential structural component of chlorophyll,is absorbed from the soil by roots and transported to shoots to support photosynthesis in ***,the molecular mechanisms underlying root-to-shoot Mg^(2+)translocation remain largely *** describe here the identification of four plasma membrane(PM)-localized transporters,named Mg^(2+)release transporters(MGRs),that are critical for root-to-shoot Mg transport in *** complementation assays in a Mg^(2+)-uptake-defi-cient bacterial strain confirmed that these MGRs conduct Mg^(2+)***-localized MGRs(MGR4,MGR5,MGR6,and MGR7)were expressed primarily in root stellar cells and participated in the xylem loading step of the long-distance Mg^(2+)transport *** particular,MGR4 and MGR6 played a major role in shoot Mg homeostasis,as their loss-of-function mutants were hypersensitive to low Mg^(2+)but tolerant to high Mg^(2+)*** grafting analysis further demonstrated that MGR4 functions in the root to determine shoot Mg^(2+)accumulation and physiological phenotypes caused by both low-and high-Mg^(2+)*** together,our study has identified the long-sought transporters responsible for root-to-shoot Mg^(2+)translocation in plants.

关键词： functional conservation metal nutrient magnesium long-distance transport phenotyping

Ensemble Model for Spindle Thermal Displacement Prediction of Machine Tools

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 319-343页

作者： ping-Huan Kuo Ssu-chi Chen chia-Ho Lee Po-chien Luan Her-Terng Yau Department of Mechanical Engineering National Chung Cheng UniversityChiayi62102Taiwan Advanced Institute of Manufacturing with High-Tech Innovations(aiM-HI) National Chung Cheng UniversityChiayi62102Taiwan

Numerous factors affect the increased temperature of a machine tool, including prolonged and high-intensity usage,tool-workpiece interaction, mechanical friction, and elevated ambient temperatures, among others. Consequently,spindle thermal displacement occurs, and machining precision suffers. To prevent the errors caused by thetemperature rise of the Spindle fromaffecting the accuracy during themachining process, typically, the factory willwarm up themachine before themanufacturing ***, if there is noway to understand the tool spindle’sthermal deformation, the machining quality will be greatly affected. In order to solve the above problem, thisstudy aims to predict the thermal displacement of the machine tool by using intelligent algorithms. In the practicalapplication, only a few temperature sensors are used to input the information into the prediction model for realtimethermal displacement prediction. This approach has greatly improved the quality of tool ***,each algorithm has different performances in different environments. In this study, an ensemble model is used tointegrate Long Short-TermMemory (LSTM) with Support VectorMachine (SVM). The experimental results showthat the prediction performance of LSTM-SVM is higher than that of other machine learning algorithms.

关键词： Thermal displacement ensemble model LSTM milling machine spindle

Screening and prevention of hepatitis C virus reactivation during chemotherapy

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World Journal of Gastroenterology 2021年第31期27卷 5181-5188页

作者： Yuan-Rung Li Tsung-Hui Hu Wen-chi Chen ping-I Hsu Hui-Chun Chen Department of Internal Medicine Kaohsiung Veterans General HospitalKaohsiung 813Taiwan Department of Internal Medicine Chang Gung University College of MedicineKaohsiung 833Taiwan Division of Gastroenterology and Hepatology Department of Internal MedicineKaohsiung Veterans General HospitalKaohsiung 813Taiwan Department of Radiation Oncology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 833Taiwan

Hepatitis C virus(HCV)reactivation occurs in 23%of HCV-infected cancer patients receiving ***-three percent of the patients with reactivation of HCV during chemotherapy develop a hepatitis *** of the cancer patients with HCV reactivation have an unremarkable clinical course following an HCV-related hepatitis flare during ***,26%–57%of the cancer patients developing an acute flare of chronic hepatitis C during chemotherapy require unanticipated discontinuation or dose reduction of chemotherapy,which results in deleterious changes in the cancer treatment *** an optimal strategy for HCV screening in cancer patients receiving chemotherapy has not been established,universal pre-chemotherapy HCV testing for patients with hematological malignancies is recommended by current *** the currently approved direct-acting antivirals(DAAs)can be used in cancer patients,but the use of DAAs during chemotherapy should avoid drug–drug interactions between chemotherapy and antiviral *** there are no contraindications or anticipated drug–drug interactions,DAAs treatment can be administered before,during,or after *** conclusion,HCV reactivation occurs in approximately one-fourth of HCV-infected cancer patients receiving *** HCV-related hepatitis flare during chemotherapy may lead to the discontinuation of potentially life-saving ***,universal HCV screening is recommended in hematological malignancy patients before chemotherapy,but there is no evidence-based guideline for other cancer *** treatment can cure HCV infection and prevent HCV reactivation during chemotherapy.

关键词： Hepatitis C virus Chemotherapy Screening Reactivation Hepatitis flare

What triggered the Asian elephant’s northward migration across southwestern Yunnan?

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The Innovation 2021年第3期2卷 15-16页

作者： Haijun Wang Puze Wang Xu Zhao Wenxia Zhang Jing Li chi Xu ping Xie Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650504China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China School of Life Sciences Nanjing UniversityNanjing 210033China Donghu Experimental Station of Lake Ecosystems State Key Laboratory of Freshwater Ecology and BiotechnologyInstitute of HydrobiologyChinese Academy of SciencesWuhan 430072China

The Asian elephant(Elephas maximus),an endangered species on the International Union for Conservation of Nature Red List,is the largest terrestrial animal living in *** require a relatively large space to live *** china,the wild Asian elephants exist only in XiShuangBanNa,Pu’Er,and LinCang of southern Yunnan Province,with 95%of the wild population residing in the XiShuangBanNa National Nature *** recent years,territorial conflicts have arisen between humans and elephants around the national nature reserve.A herd of wild Asian elephants roamed north,venturing over 500 km from the largest area of the reserve,MengYang(998 km^(2),600–1,500 m above sea level[ASL]in altitude),in March of 2020 to KunMing(the capital of Yunnan Province,ca.2000 m ASL in altitude)in early June 2021(Figure 1A).These elephants,traipsing north through fields,highways,villages,and towns,have stepped into the international spotlight,not only because such long-distance migration never happened in the past half a century but also because the United Nations Biodiversity Conference will be held in KunMing in the coming ***,no one knows exactly why this has happened,as elephant migration,a complex ecological process,can be of varied duration,distance,timing,and driver.

关键词： southwestern Figure migration

Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1395-1406页

作者： Qiu-Xiao Yu ping-Ying Fu chi Zhang Li Li Wen-Ting Huang Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and the second most common cause of cancer-related mortality ***-epithelial transition factor(MET)gene participates in multiple tumor biology and shows clinical potential for pharmacological manipulation in tumor *** amplification has been reported in CRC,but data are very *** pathological values of MET in CRC may provide new therapeutic and genetic screening options in future clinical *** To determine the pathological significance of MET amplification in CRC and to propose a feasible screening *** A number of 205 newly diagnosed CRC patients undergoing surgical resection without any preoperative therapy at Shenzhen Cancer Hospital of chinese Academy of Medical Sciences were *** patients were without RAS/RAF mutation or microsatellite *** amplification and c-MET protein expression were analyzed using fluorescence in situ hybridization(FISH)and immunohistochemistry(IHC),*** between MET aberration and pathological features were detected using the chi-squared *** free survival(PFS)during the two-year follow-up was detected using the Kaplan-Meier method and log rank *** results of MET FISH and IHC were com pared using one-way *** Polysomy-induced MET amplification was observed in 14.4%of cases,and focal MET amplification was not ***-induced MET amplification was associated with a higher frequency of lymph node metastasis(LNM)(P<0.001)and higher tumor budding grade(P=0.02).In the survival analysis,significant difference was detected between patients with amplified-and non-amplified MET in a two-year follow-up after the first diagnosis(P=0.001).C-MET scores of 0,1+,2+,and 3+were observed in 1.4%,24.9%,54.7%,and 19.0%of tumors,respectively.C-MET overexpression correlated with higher frequency of LNM(P=0.002),but no significant difference of PFS was dete

关键词： Colorectal cancer MET Amplification Pathological features Prognosis Fluorescence in situ hybridization

服用不同剂量姜黄素对大鼠血清酶及肝、心肌组织运动损伤的影响

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食品科学 2005年第8期26卷 364-366页

作者：池爱平熊正英陕西师范大学运动生物学研究所陕西西安710062

通过灌服不同剂量姜黄素,测试了大鼠在疲劳运动后血清肌酸激酶(CK)、谷草转氨酶(SGOT)、谷丙转氨酶(SGPT)、乳酸脱氢酶(LDH)的活性和心肌、肝组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)活性和丙二醛(MDA)... 详细信息

通过灌服不同剂量姜黄素,测试了大鼠在疲劳运动后血清肌酸激酶(CK)、谷草转氨酶(SGOT)、谷丙转氨酶(SGPT)、乳酸脱氢酶(LDH)的活性和心肌、肝组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)活性和丙二醛(MDA)含量。旨在研究服用不同剂量姜黄素对大鼠由于运动导致不同组织自由基损伤的保护作用。结果表明,服用不同剂量姜黄素使大强度运动大鼠血清CK、SGOT、SGPT、LDH活性有不同程度的下降;大鼠心肌、肝组织SOD、CAT、GSH-Px活性都有不同程度的升高、MDA含量显著降低(p<0.05),并呈一定量效关系。结论:姜黄素对疲劳运动所致大鼠肝和心肌组织自由基损伤具有明显保护作用。

关键词：姜黄素运动自由基大鼠

Curent Situation of “Candidatus Liberibacter asiaticus” in Guangdong,china,Where Citrus Huanglongbing Was First Described

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Journal of Integrative Agriculture 2012年第3期11卷 424-429页

作者： DENG Xiao-ling GAO Yi-di CHEN Jian-chi PU Xue-lian KONG Wei-wen LI Hua-ping Laboratory of Citrus Huanglongbing Research South China Agricultural University Guangzhou 510642 P.R. China San Joaquin Valley Agricultural Sciences Center USDA-ARS Parlier California 93648 USA School of Horticulture and Plant Protection Yangzhou University Yangzhou 225009 P.R. China

Citrus Huanglongbing （HLB,yellow shoot disease） was first observed in the coastal Chaoshan Plain of Guangdong Province,china,in the late 19th century based on descriptions of yellow shoot symptoms. “Candidatus Liberibacter asiaticus”has been considered as a putative pathogen associated with HLB since *** about the curent prevalence of this bacterium is important for HLB control in Guangdong and also provides useful reference for HLB study *** 2007,we collected HLB symptomatic citrus samples from 16 cultivars in 12 prefecture cities,mostly in the north and west regions of Guangdong,where major citrus fruits are currently *** the 359 samples collected,241 （67.1%） were positive for “***”,distributed in 15 out of the 16 cultivars from all 12 cities,indicating the widespread prevalence of “***” in Guangdong *** detection rates varied from 16.7 to 100% depending on location and *** detection rates were found in newer citrus cultivation cities among the previously less popular but now promoted *** reviewing the citrus management and pest control practice,we believe that infected nursery stocks play a key role in the current spread of “***”.

关键词： citrus Huanglongbing Candidatus Liberibacter asiaticus

姜黄素对运动训练大鼠血清某些生化指标的影响

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体育科学 2005年第9期25卷 41-45页

作者：熊正英池爱平陕西师范大学体育学院暨运动生物学研究所陕西西安710062

通过灌服姜黄素溶液,揭示姜黄素对大强度耐力训练大鼠运动能力影响的生物化学机制。以SD雄性大鼠为实验对象,采用递增强度跑台训练,建立大强度耐力运动模型,测定血清酶活性及反映大鼠物质与能量代谢的一些生化指标。结果显示,姜黄素能... 详细信息

通过灌服姜黄素溶液,揭示姜黄素对大强度耐力训练大鼠运动能力影响的生物化学机制。以SD雄性大鼠为实验对象,采用递增强度跑台训练,建立大强度耐力运动模型,测定血清酶活性及反映大鼠物质与能量代谢的一些生化指标。结果显示,姜黄素能改善大鼠由于大强度耐力训练造成的Hb含量下降,使大鼠Hb含量明显上升;姜黄素组运动大鼠血清ALT、AST、CK、LDH活性明显低于运动对照组;姜黄素组运动大鼠血清LDL、BU含量都较运动组有显著的降低;姜黄素组运动大鼠血清Cr、HDL的含量较运动对照组又有显著升高;服用姜黄素运动大鼠肌糖原和肝糖原含量都明显高于运动组。提示:姜黄素能减轻大强度耐力运动对大鼠肝脏、心肌、骨骼肌、肾脏等组织细胞的损伤;姜黄素能降低运动大鼠体内蛋白质分解,增加运动大鼠肝糖原、肌糖和磷酸肌酸能源物质的含量,提高大鼠肌肉的工作能力,使运动大鼠机体功能正常发挥;姜黄素与运动结合能更有效地调整血清甘油三酯、胆固醇、高密度脂蛋白和低密度脂蛋白的代谢,对心血管系统有一定的保护作用;姜黄素能够保证大强度运动时运动大鼠神经、肌肉等组织的糖供应,从而提高运动大鼠的运动能力,延缓大鼠运动性疲劳的产生。

关键词：姜黄素耐力训练生物化学血清鼠动物实验

Risk factors for proton pump inhibitor refractoriness in chinese patients with non-erosive reflux disease

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World Journal of Gastroenterology 2013年第20期19卷 3124-3129页

作者： Xiao-ping Niu Bao-ping Yu Yun-Dong Wang Zhen Han Shao-Fen Liu chi-Yi He Guo-Zheng Zhang Wan-Chun Wu Department of Gastroenterology Yijishan HospitalWannan Medicine College Department of Gastroenterology Renmin HospitalWuhan University

aiM:To analyze risk factors for refractoriness to proton pump inhibitors(PPIs) in patients with non-erosive reflux disease(NERD).METHODS:A total of 256 NERD patients treated with the PPI esomeprazole were *** were classified into symptom-free and residual symptoms groups according to Quality of Life in Reflux and Dyspepsia(QolRad) *** subjects completed questionnaires on psychological status(self-rating anxiety scale;selfrating depression scale) and quality of life scale(Short Form 36).Multivariate analysis was used to determine the predictive factors for PPI ***:According to QolRad,97 patients were confirmed to have residual reflux symptoms,and the remaining 159 patients were considered symptom *** were no significant differences between the two groups in lifestyle factors(smoking and alcohol consumption),age,Helicobacter pylori infection,and hiatal *** were significant differences between the two groups in relation to sex,psychological distress including anxiety and depression,body mass index(BMI),and irritable bowel syndrome(IBS)(P < 0.05).Logistic regression analysis found that BMI < 23,comorbid IBS,anxiety,and depression were major risk factors for PPI *** patients had a lower quality of life compared with symptom-free ***:Some NERD patients are refractory to PPIs and have lower quality of *** symptoms are associated with psychological distress,intestinal disorders,and low BMI.

关键词： Risk factors Refractoriness Proton pump inhibitors Non-erosive reflux disease